Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by STENVERS, J.-W.
Right arrow Articles by HUGO MEIJER, A. E. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by STENVERS, J.-W.
Right arrow Articles by HUGO MEIJER, A. E. F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Brain, Vol. 106, No. 3, 601-612, 1983
© 1983 Guarantors of Brain

research-article

MOTOR ACTIVITY AND MUSCLE PROPERTIES IN THE HEMIDECEREBELLATE CAT

JAN-WILLEM STENVERS1,2, OTTO EERBEEK1, J. M. B. VIANNEY DE JONG2 and A. E. F. HUGO MEIJER3

1From the Laboratory of Neurophysiology Eerste Constantijn Huygensstraat 20, 1054 WB Amsterdam 2Jan Swammerdam Institute Eerste Constantijn Huygensstraat 20, 1054 WB Amsterdam Laboratories of Experimental Neurology Eerste Helmersstraat 104, 1054 EG Amsterdam, The Netherlands 3Pathological Anatomy, Histochemical and Biochemical Section, Academic Hospital Wilhelmina Gasthuis Eerste Helmersstraat 104, 1054 EG Amsterdam, The Netherlands

Luciani's ipsilaterally acting ‘trophic’ cerebellar influence on striated muscle was reinvestigated in hemidecerebellate preparations of varying extent. Cats with hindlimb postural asymmetries for 4 or more days after the lesion developed a bilateral reduction of maximum tetanic tension and increased twitch/tetanus ratios of soleus. In addition, soleus on the side of the lesion lost force and weight, showed decreased twitch contraction and half-relaxation times, elevated myosin ATPase activity in part of its fibres, occasional fibre necrosis and a few snake coils.

Protracted postural asymmetry occurred only if complete hemicerebellectomy included ablation of the lateral vestibular nucleus and extended for at least 3.0 mm across the midline into the contralateral vermal and intermediate cortex, especially of Larsell's lobuli IV and V. Most simply, the cerebellar effect on muscle is explained as the result of altered motoneuronal activation patterns.

Comparison of the experimental soleus changes with Holmes's clinical findings in cases of cerebellar injury suggests that muscle itself participates in experimental and human cerebellar asthenia.

Received July 1, 1982. Revised October 5, 1982.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.