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Brain, Vol. 106, No. 3, 643-653, 1983
© 1983 Guarantors of Brain

research-article

SPONTANEOUS EYE-BLINK RATES AND DOPAMINERGIC SYSTEMS

CRAIG N. KARSON

From the Adult Psychiatry Branch, Division of Special Mental Health Research, National Institute of Mental Health, Saint Elizabeths Hospital Washington, DC 20032

A series of studies demonstrated a possible relationship between eye-blink rate and central dopamine activity. First, apomorphine and other dopamine agonists acutely increased blink rate in monkeys, an effect blocked by sulpiride. Secondly, parkinsonian patients with levodopa-induced dyskinesia exhibited twice the mean blink rate (21 blinks/min) of other parkinsonians (11 blinks/min, P < 0.002) whereas the more symptomatic of the nondyskinetic patients had a very slow rate (3 blinks/min, P < 0.01). Thirdly, schizophrenic patients had an elevated mean blink (31 vs 23 blinks/min for normals, P < 0.05) which was normalized by neuroleptic treatment. Thus, the correlation with central dopamine activity may also prove clinically useful in selected neuropsychiatric disorders.

Received June 1, 1982. Revised January 4, 1983.
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