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Brain, Vol. 113, No. 3, 659-675, 1990
© 1990 Guarantors of Brain

research-article

QUANTITATIVE ASSESSMENT OF CLASS II MOLECULES IN NORMAL AND PATHOLOGICAL NERVES

IMMUNOCYTOCHEMICAL STUDIES IN VIVO AND IN TISSUE CULTURE

ELIO SCARPINI, ROBERT P. LISAK1, SANDRO BERETTA, MARIAELENA VELICOGNA, RICCARDO DORONZO, MAURIZIO MOGGIO, STEFANO JANN and GUGLIELMO SCARLATO

Institute of Neurology, Dino Ferrari Centre, University of Milan Italy 1Department of Neurology, Wayne State University Detroit, MI, USA

Correspondence to: Correspondence to: Dr Elio Scarpini, Institute of Neurology, Via F. Sforza 35, 20122 Milan, Italy.

We have analysed class II molecules (HLA-DR) expression in human fetal nerves at different stages of gestation, in human control nerves and in nerves of patients with peripheral neuropathies of different aetiology. Immunochemical demonstration of HLA-DR antigens was also performed on isolated human Schwann cells at different times in culture, from the same nerves.

In normal nerves, HLA-DR positive material is localized only on endothelial and perivascular cells and in rare perineurial and endoneurial cells. In fetal nerves, HLA-DR positive material is already present by the sixteenth week of gestation. Quantitative analysis of HLA-DR molecules density in pathological nerves showed a wide heterogeneity in different neuropathies with no correlation between the type of pathology and the intensity and pattern of staining. Cultured human Schwann cells obtained from fetal, normal adult and pathological (vasculitic neuropathy) nerves were HLA-DR positive and the percentage of positive cells increased with time in culture. DR antigen appearance on human Schwann cells may reflect not only an immunologically-mediated phenomenon but also a dependence on axon-Schwann cell interaction.

Received July 26, 1988. Revised April 25, 1989. Accepted June 16, 1989.


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