Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (112)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Benecke, R.
Right arrow Articles by Weiss, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Benecke, R.
Right arrow Articles by Weiss, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Brain, Vol. 116, No. 6, 1451-1463, 1993
© 1993 Guarantors of Brain

research-article

Electron transfer complexes I and IV of platelets are abnormal in Parkinson's disease but normal in Parkinson-plus syndromes

Reiner Benecke1, Petra Strümper2 and Hanns Weiss2

1Neurologische Klinik and the Düsseldorf, Germany 2Institut für Biochemie of the Heinrich-Heine-Universitas Düsseldorf, Germany

Correspondence to: Correspondence to: Professor Dr Hanns Weiss, Institut für Biochemie, Heinrich-Heine-Universitat, Dusseldorf, Universitatsstraße 1, 40225 Dusseldorf 1, Germany.

Using a technique which requires only 100 ml blood we investigated the electron transfer complexes (ETC) I, III and IV in platelet mitochondria of 44 control subjects, 27 patients with idiopathic Parkinson's disease and eight patients with Parkinson-plus syndromes due to multiple system atrophy. In both control subjects and patients, ETC measurements were repeated at intervals of several months. The activities varied considerably among normal subjects, but intra-individual variation of ETC activities were low at repetitive measurements. In normal subjects there was no correlation between enzyme activities and age or training state. There was no difference in enzyme activities between smokers and non-smokers in the control group. Complex I activity was lower in Parkinson's disease patients than in controls (14 versus 29 nmol/min/mg platelet protein; P < 0.001). Furthermore, the group difference in complex IV activity also reached statistical significance (83 Versus 58 nmol/min/mg platelet protein; P < 0.001). Additionally, in some Parkinson's disease patients, activities of complex III were low and lay outside the control range, but the group difference did not reach significance. There was no correlation between complex I activity and disease duration or severity as well as the daily L-dopa dose in Parkinson's disease patients. Repeated measurements in five Parkinson's disease patients in the earliest stages of their illness demonstrated that the decrease in complex I and IV activities can develop rapidly within 1 year. In Parkinsonplus patients suffering from multiple system atrophy the ETC activities were normal.

Received February 1, 1993. Revised July 9, 1993. Accepted August 8, 1993.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
W. Suthammarak, Y.-Y. Yang, P. G. Morgan, and M. M. Sedensky
Complex I Function Is Defective in Complex IV-deficient Caenorhabditis elegans
J. Biol. Chem., March 6, 2009; 284(10): 6425 - 6435.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. A. Gautier, T. Kitada, and J. Shen
From the Cover: Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
PNAS, August 12, 2008; 105(32): 11364 - 11369.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
J. Jin, C. Hulette, Y. Wang, T. Zhang, C. Pan, R. Wadhwa, and J. Zhang
Proteomic Identification of a Stress Protein, Mortalin/mthsp70/GRP75: Relevance To Parkinson Disease
Mol. Cell. Proteomics, July 1, 2006; 5(7): 1193 - 1204.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
C. W. Shults, D. Oakes, K. Kieburtz, M. F. Beal, R. Haas, S. Plumb, J. L. Juncos, J. Nutt, I. Shoulson, J. Carter, et al.
Effects of Coenzyme Q10 in Early Parkinson Disease: Evidence of Slowing of the Functional Decline
Arch Neurol, October 1, 2002; 59(10): 1541 - 1550.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.