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Brain, Vol. 117, No. 2, 289-305, 1994
© 1994 Oxford University Press

research-article

Event-related brain potential evidence for a verbal working memory deficit in multiple sclerosis

Daniel S. Ruchkin1,, Jordan Grafman3, Gregory L. Krauss2, Ray Johnson, Jr4, Howard Canoune1 and Walter Ritter5

1Department of Physiology, School of Medicine, University of Maryland Baltimore, Maryland 2Department of Neurology, Johns Hopkins Hospital Baltimore, Maryland 3Cognitive Neuroscience Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke Bethesda, Maryland 4Department of Psychology, Queens College, City University of New York Flushing 5Department of Neuroscience, Albert Einstein College of Medicine and Department of Psychology, Lehman College, City University of New York New York, USA

Correspondence to: Correspondence to: Daniel S. Ruchkin,University of Maryland, School of Medicine, Department of Physiology Baltimore, MD 21201-1559, USA

Memory deficits are frequently identified in patients with multiple sclerosis. Both working (short-term) and long-term memory appear affected, particularly on free-recall tasks. The focus of our study was to examine neurophysiological correlates of working memory processes and to identify the specific components responsible for the working memory deficits reported in multiple sclerosis. Event-related brain potentials (ERPs) were recorded from the scalp of mildly afflicted multiple sclerosis patients and their matched normal controls during the performance of phonological and visuo-spatial working memory tasks. Neuropsychological test, behavioural performance and ERP data all indicated that verbal working memory is especially susceptible to impairment by multiple sclerosis, while visuospatial working memory is less susceptible. The pattern of results further indicated that the verbal working memory dysfunction in multiple sclerosis is at least partially due to impairment in the phonological loop, a rehearsal mechanism for retaining verbal information in working memory.

multiple sclerosis; working memory; phonological loop; event-related potentials; left anterior negativity

Received August 3, 1993. Revised October 20, 1993. Accepted October 21, 1993.


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