Brain, Vol. 117, No. 2, 307-315, 1994
© 1994 Oxford University Press
research-article |
Increased expression of high affinity IL-2 receptors and ß-adrenoceptors on peripheral blood mononuclear cells is associated with clinical and MRI activity in multiple sclerosis
1Multiple Sclerosis Laboratory London, UK 2NMR Research Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery London, UK
Correspondence to:
Dr Y. Zoukos, Institute of Neurology, Multiple Sclerosis Laboratory, 1 Wakefield Street, London WC1N 1PJ, UK
Enhanced expression of ß-adrenoceptor densities on peripheral blood mononuclear cells (PBMCs) in progressive multiple sclerosis patients has been observed in a number of independent studies. A link between increased number of ß-adrenoceptors and inflammatory disease has been further indicated by studies in rheumatoid arthritis and relapsing— remitting multiple sclerosis patients. In a serial monthly assessment of relapsing—remitting multiple sclerosis patients, we have demonstrated that increased ß-adrenoceptors on PBMCs correlate with the expression of high affinity interleukin-2 receptors (IL-2Rs) and disease activity as determined by clinical and MRI findings. Magnetic resonance imaging activity was strongly correlated with IL-2R expression and it appears to be a sensitive marker of PBMC immunoactivation in multiple sclerosis. In vitro studies showed that ß-agonist stimulation of PBMCs reduces the IL-2R expression and suppresses cell proliferation following mitogenic stimulation. This observation may indicate a recovery role for the enhanced ß-adrenoceptor expression in multiple sclerosis. However, its therapeutic importance remains to be tested by appropriate trials using either ß-agonists or agents activating the second messenger system, c-AMP, in lymphocytes.
ß-adrenoceptors; IL-2 receptors; multiple sclerosis; MRI
Received June 28, 1993. Revised October 18, 1993. Accepted December 17, 1993.
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