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Brain, Vol. 117, No. 6, 1351-1356, 1994
© 1994 Guarantors of Brain

research-article

Central demyelination induced in vivoby the calcium ionophore ionomycin

K. J. Smith1,2, and S. M. Hall1

1Division of Anatomy and Cell Biology London, UK 2Department of Neurology, United Medical and Dental Schools London, UK

Correspondence to: Correspondence to: K. J. Smith, Department of Neurology, United Medical and Dental Schools, Guy's Campus, London SE1 9RT, UK

The effects of injecting the calcium-selective ionophore, ionomycin, into myelinated tracts in the dorsal columns of adult rat spinal cords were examined electron microscopically. In vivo, ionomycin induced a primary vesicular demyelination, together with a variable degree of axonal degeneration, in a dose-dependent manner. The results are consistent with previous demonstrations that mature oligodendrocytes are more vulnerable to alterations in levels of [Ca2+]i than other glial cells. We speculate that demyelination induced by ionomycin in vivo occurs as a result of direct activation of endogenous Ca2+dependent enzymes and/or as a consequence of oligodendrocyte injury mediated via astrocytes.

ionomycin; dorsal columns; demyelination; Ca2+

Received May 9, 1994. Revised July 25, 1994. Accepted July 30, 1994.


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