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Brain, Vol. 119, No. 6, 1835-1848, 1996
© 1996 Guarantors of Brain

research-article

A clinical and neurophysiological study of a patient with an extensive transection of the spinal cord sparing only a part of one anterolateral quadrant

N. Danziger1, P. Rémy3, B. Pidoux1, D. Dormont2, Y. Samson3, E. Fournier1, P. D. Wall4 and J. C. Wilier1,

1Laboratoire de Neurophysiologie, Hopital Pitie-Salpetriere Paris 2Service de Neuroradiologie, Hôpital de la Pitie Paris 3Service hospitalier Frédéric Joliot Orsay, France 4Department of Physiology, St Thomas' Hospital London, UK

Correspondence to: Correspondence to: J. C. Willer, Laboratoire de Neurophysiologie Clinique, Hopital Pitié-Salpêtriére, 47, Bd. de l'Hôpital, 75013 Paris, France

In 1976, Noordenbos and Wall studied sensory functions in a woman with a surgically verified T3 spinal cord transection which spared only a part of the left anterolateral quadrant. We re-investigated this unique case 18 years after the lesion and included a comparable sensory examination, MRI of the spinal cord, somatosensory evoked potentials, PET-activation study during hand and foot vibration and analysis of flexion reflex modulation during the Jendrassik manoeuvre. Our results show that the residual anterolateral quadrant contains ascending pathways carrying a wide range of sensory information as well as descending pathways modulating flexion reflex activity at the spinal level. Moreover, the changes in sensory functions and the unique pattern of cortical activation suggest a functional reorganization of the connectivity between the periphery and the cerebral cortex. Changes of facilitation and/or of inhibition at different levels of the somatosensory system may account for these longterm plastic changes.

spinal cord; sensory pathways; CNS plasticity

Received April 22, 1996. Revised July 25, 1996. Accepted August 2, 1996.


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