Brain, Vol 120, Issue 11 2059-2069, Copyright © 1997 by Oxford University Press
F Barkhof, M Filippi, DH Miller, P Scheltens, A Campi, CH Polman, G Comi, HJ Ader, N Losseff and J Valk
We compared MRI criteria used to predict conversion of suspected multiple
sclerosis to clinically definite multiple sclerosis. Seventy- four patients
with clinically isolated neurological symptoms suggestive of multiple
sclerosis were studied with MRI. Logistic regression analysis was used to
remove redundant information, and a diagnostic model was built after each
MRI parameter was dichotomized according to maximum accuracy using receiver
operating characteristic analysis. Clinically definite multiple sclerosis
developed in 33 patients (prevalence 45%). The optimum cut-off point
(number of lesions) was one for most MRI criteria (including
gadolinium-enhancement and juxta- cortical lesions), but three for
periventricular lesions, and nine for the total number of T2-lesions. Only
gadolinium-enhancement and juxta- cortical lesions provided independent
information. A final model which, in addition, included infratentorial and
periventricular lesions, had an accuracy of 80%, and having more abnormal
criteria, predicted conversion to clinically definite multiple sclerosis
strongly. The model performed better than the criteria of Paty et al.
(Neurology 1988; 38: 180-5) and of Fazekas et al. (Neurology 1988; 38:
1822-5). We concluded that a four-parameter dichotomized MRI model
including gadolinium-enhancement, juxtacortical, infratentorial and
periventricular lesions best predicts conversion to clinically definite
multiple sclerosis.
REVIEWS
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis
Department of Diagnostic Radiology, Vrije Universiteit Hospital, Amsterdam, The Netherlands.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  B. Moraal, C. Pohl, B. M. J. Uitdehaag, C. H. Polman, G. Edan, M. S. Freedman, H.-P. Hartung, L. Kappos, D. H. Miller, X. Montalban, et al. Magnetic Resonance Imaging Predictors of Conversion to Multiple Sclerosis in the BENEFIT Study Arch Neurol, November 1, 2009; 66(11): 1345 - 1352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Outteryck, H. Zephir, S. Defoort, M. Bouyon, P. Debruyne, I. Bouacha, D. Ferriby, A. Lacour, P. Labalette, J. de Seze, et al. Optical Coherence Tomography in Clinically Isolated Syndrome: No Evidence of Subclinical Retinal Axonal Loss Arch Neurol, November 1, 2009; 66(11): 1373 - 1377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Young, S. Quinn, M. Hurrell, and B. Taylor Clinically isolated acute transverse myelitis: prognostic features and incidence Multiple Sclerosis, November 1, 2009; 15(11): 1295 - 1302. [Abstract] [PDF]
|
|
|
|
 |
|
 C-P Lo, H-W Kao, S-Y Chen, C-J Hsueh, W-C Lin, W-L Hsu, D-K Wu, and G-C Liu Prediction of conversion from clinically isolated syndrome to clinically definite multiple sclerosis according to baseline MRI findings: comparison of revised McDonald criteria and Swanton modified criteria J. Neurol. Neurosurg. Psychiatry, October 1, 2009; 80(10): 1107 - 1109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Goodin and D. Bates Review: Treatment of early multiple sclerosis: the value of treatment initiation after a first clinical episode Multiple Sclerosis, October 1, 2009; 15(10): 1175 - 1182. [Abstract] [PDF]
|
|
|
|
 |
|
 S Appenzeller, M Veilleux, and A Clarke Third cranial nerve palsy or pseudo 3rd nerve palsy of myasthenia gravis? A challenging diagnosis in systemic lupus erythematosus Lupus, August 1, 2009; 18(9): 836 - 840. [Abstract] [PDF]
|
|
|
|
|
|
A Siva, S Saip, A Altintas, A Jacob, B. Keegan, and O. Kantarci Multiple sclerosis risk in radiologically uncovered asymptomatic possible inflammatory-demyelinating disease Multiple Sclerosis, August 1, 2009; 15(8): 918 - 927. [Abstract] [PDF]
|
|
|
|
|
|
C. Lebrun, C. Bensa, M. Debouverie, S. Wiertlevski, D. Brassat, J. de Seze, L. Rumbach, J. Pelletier, P. Labauge, B. Brochet, et al. Association Between Clinical Conversion to Multiple Sclerosis in Radiologically Isolated Syndrome and Magnetic Resonance Imaging, Cerebrospinal Fluid, and Visual Evoked Potential: Follow-up of 70 Patients Arch Neurol, July 1, 2009; 66(7): 841 - 846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Matsushita, N Isobe, T Matsuoka, N Shi, Y Kawano, X. Wu, T Yoshiura, Y Nakao, T Ishizu, and J. Kira Aquaporin-4 autoimmune syndrome and anti-aquaporin-4 antibody-negative opticospinal multiple sclerosis in Japanese Multiple Sclerosis, July 1, 2009; 15(7): 834 - 847. [Abstract] [PDF]
|
|
|
|
|
|
J. Cabrera-Gomez, M Bonnan, A Gonzalez-Quevedo, A Saiz-Hinarejos, R Marignier, S Olindo, F Graus, D Smadja, H Merle, L Thomas, et al. Neuromyelitis optica positive antibodies confer a worse course in relapsing-neuromyelitis optica in Cuba and French West Indies Multiple Sclerosis, July 1, 2009; 15(7): 828 - 833. [Abstract] [PDF]
|
|
|
|
|
|
M Nakamura, T Misu, K Fujihara, I Miyazawa, I Nakashima, T Takahashi, S Watanabe, and Y Itoyama Occurrence of acute large and edematous callosal lesions in neuromyelitis optica Multiple Sclerosis, June 1, 2009; 15(6): 695 - 700. [Abstract] [PDF]
|
|
|
|
|
|
A. Rovira, J. Swanton, M. Tintore, E. Huerga, F. Barkhof, M. Filippi, J. L. Frederiksen, A. Langkilde, K. Miszkiel, C. Polman, et al. A Single, Early Magnetic Resonance Imaging Study in the Diagnosis of Multiple Sclerosis Arch Neurol, May 1, 2009; 66(5): 587 - 592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Boster, S. Hreha, J. R. Berger, F. Bao, R. Penmesta, A. Tselis, C. Endress, I. Zak, J. Perumal, C. Caon, et al. Progressive Multifocal Leukoencephalopathy and Relapsing-Remitting Multiple Sclerosis: A Comparative Study Arch Neurol, May 1, 2009; 66(5): 593 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Zephir, D Lefranc, S Dubucquoi, J de Seze, L Boron, L Prin, and P Vermersch Serum IgG repertoire in clinically isolated syndrome predicts multiple sclerosis Multiple Sclerosis, May 1, 2009; 15(5): 593 - 600. [Abstract] [PDF]
|
|
|
|
|
|
M. Freedman, J Laks, N Dotan, R. Altstock, A Dukler, and C. Sindic Anti-{alpha}-glucose-based glycan IgM antibodies predict relapse activity in multiple sclerosis after the first neurological event Multiple Sclerosis, April 1, 2009; 15(4): 422 - 430. [Abstract] [PDF]
|
|
|
|
|
|
V Zipoli, B Hakiki, E Portaccio, F Lolli, G Siracusa, M Giannini, L Pantoni, F Pescini, S Sorbi, and M. Amato The contribution of cerebrospinal fluid oligoclonal bands to the early diagnosis of multiple sclerosis Multiple Sclerosis, April 1, 2009; 15(4): 472 - 478. [Abstract] [PDF]
|
|
|
|
 |
|
 D.J.A. Callen, M. M. Shroff, H. M. Branson, T. Lotze, D. K. Li, D. Stephens, and B. L. Banwell MRI in the diagnosis of pediatric multiple sclerosis Neurology, March 17, 2009; 72(11): 961 - 967. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhang, J. Jin, Y. Tang, D. Speer, D. Sujkowska, and S. Markovic-Plese IFN-{beta}1a Inhibits the Secretion of Th17-Polarizing Cytokines in Human Dendritic Cells via TLR7 Up-Regulation J. Immunol., March 15, 2009; 182(6): 3928 - 3936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Okuda, E. M. Mowry, A. Beheshtian, E. Waubant, S. E. Baranzini, D. S. Goodin, S. L. Hauser, and D. Pelletier Incidental MRI anomalies suggestive of multiple sclerosis: The radiologically isolated syndrome Neurology, March 3, 2009; 72(9): 800 - 805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bourdette and J. Simon The radiologically isolated syndrome: Is it very early multiple sclerosis? Neurology, March 3, 2009; 72(9): 780 - 781. [Full Text] [PDF]
|
|
|
|
|
|
M Atzori, P. Battistella, P Perini, M Calabrese, M Fontanin, A. Laverda, A Suppiej, P Drigo, P Grossi, L Rinaldi, et al. Clinical and diagnostic aspects of multiple sclerosis and acute monophasic encephalomyelitis in pediatric patients: a single centre prospective study Multiple Sclerosis, March 1, 2009; 15(3): 363 - 370. [Abstract] [PDF]
|
|
|
|
|
|
J. Cabrera-Gomez, L Ramon-Perez, A Saiz, P Llerena-Fernandez, L Fernandez-Fernandez, G Ercilla, D Grass-Fernandez, M. Robinson-Agramonte, K Romero-Garcia, R Macias-Betancourt, et al. Neuromyelitis optica and multiple sclerosis in sisters Multiple Sclerosis, February 1, 2009; 15(2): 269 - 271. [Abstract] [PDF]
|
|
|
|
|
|
M Osoegawa, J Kira, T Fukazawa, K Fujihara, S Kikuchi, M Matsui, T Kohriyama, G Sobue, T Yamamura, Y Itoyama, et al. Temporal changes and geographical differences in multiple sclerosis phenotypes in Japanese: nationwide survey results over 30 years Multiple Sclerosis, February 1, 2009; 15(2): 159 - 173. [Abstract] [PDF]
|
|
|
|
|
|
T. Kumpfel, L-A Hoffmann, H. Pellkofer, W. Pollmann, W. Feneberg, R. Hohlfeld, and P. Lohse Multiple sclerosis and the TNFRSF1A R92Q mutation: Clinical characteristics of 21 cases Neurology, November 25, 2008; 71(22): 1812 - 1820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Matsuoka, T Matsushita, M Osoegawa, Y Kawano, M Minohara, F Mihara, Y Nishimura, Y Ohyagi, and J Kira Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis Multiple Sclerosis, November 1, 2008; 14(9): 1181 - 1190. [Abstract] [PDF]
|
|
|
|
|
|
D. Miller, B. Weinshenker, M Filippi, B. Banwell, J. Cohen, M. Freedman, S. Galetta, M Hutchinson, R. Johnson, L Kappos, et al. Differential diagnosis of suspected multiple sclerosis: a consensus approach Multiple Sclerosis, November 1, 2008; 14(9): 1157 - 1174. [Abstract] [PDF]
|
|
|
|
|
|
M. Tanaka, T. Matsushita, T. Tateishi, H. Ochi, Y. Kawano, F. -J. Mei, M. Minohara, H. Murai, and J. -i. Kira Distinct CSF cytokine/chemokine profiles in atopic myelitis and other causes of myelitis Neurology, September 23, 2008; 71(13): 974 - 981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Zephir, T Stojkovic, P Latour, A Lacour, J de Seze, O Outteryck, C-A Maurage, C Monpeurt, P Chatelet, E Ovelacq, et al. Relapsing demyelinating disease affecting both the central and peripheral nervous systems J. Neurol. Neurosurg. Psychiatry, September 1, 2008; 79(9): 1032 - 1039. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Liptak, A.M. Berger, M.P. Sampat, A. Charil, O. Felsovalyi, B.C. Healy, P. Hildenbrand, S.J. Khoury, H.L. Weiner, R. Bakshi, et al. Medulla Oblongata Volume: A Biomarker of Spinal Cord Damage and Disability in Multiple Sclerosis AJNR Am. J. Neuroradiol., September 1, 2008; 29(8): 1465 - 1470. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bendszus, G. Ladewig, L. Jestaedt, B. Misselwitz, L. Solymosi, K. Toyka, and G. Stoll Gadofluorine M enhancement allows more sensitive detection of inflammatory CNS lesions than T2-w imaging: a quantitative MRI study Brain, September 1, 2008; 131(9): 2341 - 2352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Okamoto, M. Ogawa, Youwei Lin, M. Murata, S. Miyake, and T. Yamamura Review: Treatment of neuromyelitis optica: Current debate Therapeutic Advances in Neurological Disorders, July 1, 2008; 1(1): 43 - 52. [Abstract] [PDF]
|
|
|
|
|
|
D Bar-Zohar, F Agosta, D Goldstaub, and M Filippi Magnetic resonance imaging metrics and their correlation with clinical outcomes in multiple sclerosis: a review of the literature and future perspectives Multiple Sclerosis, July 1, 2008; 14(6): 719 - 727. [Abstract] [PDF]
|
|
|
|
|
|
A Boster, C Caon, J Perumal, S Hreha, R Zabad, I Zak, A Tselis, R Lisak, and O Khan Failure to develop multiple sclerosis in patients with neurologic symptoms without objective evidence Multiple Sclerosis, July 1, 2008; 14(6): 804 - 808. [Abstract] [PDF]
|
|
|
|
|
|
A Javed, R Balabanov, B. Arnason, T. Kelly, N. Sweiss, P Pytel, R Walsh, E. Blair, A Stemer, M Lazzaro, et al. Minor salivary gland inflammation in Devic's disease and longitudinally extensive myelitis Multiple Sclerosis, July 1, 2008; 14(6): 809 - 814. [Abstract] [PDF]
|
|
|
|
|
|
C. F. Lucchinetti, R. H. Gavrilova, I. Metz, J. E. Parisi, B. W. Scheithauer, S. Weigand, K. Thomsen, J. Mandrekar, A. Altintas, B. J. Erickson, et al. Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis Brain, July 1, 2008; 131(7): 1759 - 1775. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jilek, M. Schluep, P. Meylan, F. Vingerhoets, L. Guignard, A. Monney, J. Kleeberg, G. Le Goff, G. Pantaleo, and R. A. Du Pasquier Strong EBV-specific CD8+ T-cell response in patients with early multiple sclerosis Brain, July 1, 2008; 131(7): 1712 - 1721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Simo, P. Barsi, and Z. Aranyi Predictive role of evoked potential examinations in patients with clinically isolated optic neuritis in light of the revised McDonald criteria Multiple Sclerosis, May 1, 2008; 14(4): 472 - 478. [Abstract] [PDF]
|
|
|
|
|
|
T. Matsushita, T. Matsuoka, T. Ishizu, H. Kikuchi, M. Osoegawa, Y. Kawano, F. Mihara, Y. Ohyagi, and J.-i. Kira Anterior periventricular linear lesions in optic-spinal multiple sclerosis: a combined neuroimaging and neuropathological study Multiple Sclerosis, April 1, 2008; 14(3): 343 - 353. [Abstract] [PDF]
|
|
|
|
|
|
R. Q. Hintzen and G. Giovannoni CSF analysis in suspected MS: Do bands aid? Neurology, March 25, 2008; 70(13_Part_2): 1059 - 1060. [Full Text] [PDF]
|
|
|
|
|
|
J. Cabrera-Gomez, A. Saiz-Hinarejos, F. Graus, A. Gonzalez-Quevedo, R. Rodriguez-Rojas, L. Quevedo-Sotolongo, Y. Real-Gonzalez, D. Grass-Fernandez, M. Cristofol-Corominas, M. Rodriguez-Cordero, et al. Brain magnetic resonance imaging findings in acute relapses of neuromyelitis optica spectrum disorders Multiple Sclerosis, March 1, 2008; 14(2): 248 - 251. [Abstract] [PDF]
|
|
|
|
 |
|
 A Theodoridou and L Settas Demyelination in rheumatic diseases Postgrad. Med. J., March 1, 2008; 84(989): 127 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Lebrun, C Bensa, M Debouverie, J De Seze, S Wiertlievski, B Brochet, P Clavelou, D Brassat, P Labauge, E Roullet, et al. Unexpected multiple sclerosis: follow-up of 30 patients with magnetic resonance imaging and clinical conversion profile J. Neurol. Neurosurg. Psychiatry, February 1, 2008; 79(2): 195 - 198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.S. Reich, K.M. Zackowski, E.M. Gordon-Lipkin, S.A. Smith, B.A. Chodkowski, G.R. Cutter, and P.A. Calabresi Corticospinal Tract Abnormalities Are Associated with Weakness in Multiple Sclerosis AJNR Am. J. Neuroradiol., February 1, 2008; 29(2): 333 - 339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Tomassini, L. De Giglio, M. Reindl, P. Russo, I. Pestalozza, P. Pantano, T. Berger, and C. Pozzilli Anti-myelin antibodies predict the clinical outcome after a first episode suggestive of MS Multiple Sclerosis, November 1, 2007; 13(9): 1086 - 1094. [Abstract] [PDF]
|
|
|
|
|
|
M. Calabrese, N. De Stefano, M. Atzori, V. Bernardi, I. Mattisi, L. Barachino, A. Morra, L. Rinaldi, C. Romualdi, P. Perini, et al. Detection of Cortical Inflammatory Lesions by Double Inversion Recovery Magnetic Resonance Imaging in Patients With Multiple Sclerosis Arch Neurol, October 1, 2007; 64(10): 1416 - 1422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.P. Wattjes, M. Harzheim, G.G. Lutterbey, L. Klotz, H.H. Schild, and F. Traber Axonal Damage But No Increased Glial Cell Activity in the Normal-Appearing White Matter of Patients with Clinically Isolated Syndromes Suggestive of Multiple Sclerosis Using High-Field Magnetic Resonance Spectroscopy AJNR Am. J. Neuroradiol., September 1, 2007; 28(8): 1517 - 1522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Pelayo, M. Tintore, A. Rovira, J. Rio, C. Nos, E. Grive, N. Tellez, M. Comabella, and X. Montalban Polyregional and hemispheric syndromes: a study of these uncommon first attacks in a CIS cohort Multiple Sclerosis, July 1, 2007; 13(6): 731 - 736. [Abstract] [PDF]
|
|
|
|
 |
|
 R M S CARTER and P M PRETORIUS The use of CT and MRI in the characterization of intracranial mass lesions Imaging, June 1, 2007; 19(2): 173 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Matsuoka, T. Matsushita, Y. Kawano, M. Osoegawa, H. Ochi, T. Ishizu, M. Minohara, H. Kikuchi, F. Mihara, Y. Ohyagi, et al. Heterogeneity of aquaporin-4 autoimmunity and spinal cord lesions in multiple sclerosis in Japanese Brain, May 1, 2007; 130(5): 1206 - 1223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Mikaeloff, G. Caridade, S. Assi, M. Tardieu, S. Suissa, and on behalf of the KIDSEP study group of the French Hepatitis B vaccine and risk of relapse after a first childhood episode of CNS inflammatory demyelination Brain, April 1, 2007; 130(4): 1105 - 1110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A Cabrera-Gomez, L Quevedo-Sotolongo, A Gonzalez-Quevedo, S Lima, Y Real-Gonzalez, M Cristofol-Corominas, K Romero-Garcia, C Ugarte-Sanchez, J Jordan-Gonzalez, J E G. de la Nuez, et al. Brain magnetic resonance imaging findings in relapsing neuromyelitis optica Multiple Sclerosis, March 1, 2007; 13(2): 186 - 192. [Abstract] [PDF]
|
|
|
|
|
|
O. Gonen, T.A. Oberndorfer, M. Inglese, J.S. Babb, J. Herbert, and R.I. Grossman Reproducibility of Three Whole-Brain N-Acetylaspartate Decline Cohorts in Relapsing-Remitting Multiple Sclerosis AJNR Am. J. Neuroradiol., February 1, 2007; 28(2): 267 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jurewicz, M. Matysiak, C. S. Raine, and K. Selmaj Soluble Nogo-A, an inhibitor of axonal regeneration, as a biomarker for multiple sclerosis Neurology, January 23, 2007; 68(4): 283 - 287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Puccioni-Sohler, Y. Yamano, M. Rios, S.M.F. Carvalho, C. C.F. Vasconcelos, R. Papais-Alvarenga, and S. Jacobson Differentiation of HAM/TSP from patients with multiple sclerosis infected with HTLV-I Neurology, January 16, 2007; 68(3): 206 - 213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.P. Wattjes, G.G. Lutterbey, J. Gieseke, F. Traber, L. Klotz, S. Schmidt, and H.H. Schild Double Inversion Recovery Brain Imaging at 3T: Diagnostic Value in the Detection of Multiple Sclerosis Lesions AJNR Am. J. Neuroradiol., January 1, 2007; 28(1): 54 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Kappos, C. H. Polman, M. S. Freedman, G. Edan, H. P. Hartung, D. H. Miller, X. Montalban, F. Barkhof, L. Bauer, P. Jakobs, et al. Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes Neurology, October 10, 2006; 67(7): 1242 - 1249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tintore, A. Rovira, J. Rio, C. Nos, E. Grive, N. Tellez, R. Pelayo, M. Comabella, J. Sastre-Garriga, and X. Montalban Baseline MRI predicts future attacks and disability in clinically isolated syndromes. Neurology, September 26, 2006; 67(6): 968 - 972. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Imrell, A.-M. Landtblom, J. Hillert, and T. Masterman Multiple sclerosis with and without CSF bands: Clinically indistinguishable but immunogenetically distinct. Neurology, September 26, 2006; 67(6): 1062 - 1064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.P. Wattjes, M. Harzheim, C.K. Kuhl, J. Gieseke, S. Schmidt, L. Klotz, T. Klockgether, H.H. Schild, and G.G. Lutterbey Does High-field MR Imaging Have an Influence on the Classification of Patients with Clinically Isolated Syndromes According to Current Diagnostic MR Imaging Criteria for Multiple Sclerosis? AJNR Am. J. Neuroradiol., September 1, 2006; 27(8): 1794 - 1798. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Mikaeloff, G. Caridade, S. Assi, S. Suissa, M. Tardieu, and on behalf of the KIDSEP Study Group Prognostic Factors for Early Severity in a Childhood Multiple Sclerosis Cohort Pediatrics, September 1, 2006; 118(3): 1133 - 1139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Rinaldi, P. Gallo, M. Calabrese, F. Ranzato, D. Luise, D. Colavito, M. Motta, A. Guglielmo, E. Del Giudice, C. Romualdi, et al. Longitudinal analysis of immune cell phenotypes in early stage multiple sclerosis: distinctive patterns characterize MRI-active patients. Brain, August 1, 2006; 129(Pt 8): 1993 - 2007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J K Swanton, K Fernando, C M Dalton, K A Miszkiel, A J Thompson, G T Plant, and D H Miller Modification of MRI criteria for multiple sclerosis in patients with clinically isolated syndromes J. Neurol. Neurosurg. Psychiatry, July 1, 2006; 77(7): 830 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Sorensen, N. Koch-Henriksen, M. Ravnborg, J. L. Frederiksen, K a. Jensen, A. Heltberg, H. Schaldemose, S. Deth, O l. Kristensen, M. Worm, et al. Immunomodulatory treatment of multiple sclerosis in Denmark: a prospective nationwide survey Multiple Sclerosis, June 1, 2006; 12(3): 253 - 264. [Abstract] [PDF]
|
|
|
|
|
|
C. Fraser, A. Klistorner, S. Graham, R. Garrick, F. Billson, and J. Grigg Multifocal visual evoked potential latency analysis: predicting progression to multiple sclerosis. Arch Neurol, June 1, 2006; 63(6): 847 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Inglese Multiple sclerosis: new insights and trends. AJNR Am. J. Neuroradiol., May 1, 2006; 27(5): 954 - 957. [Full Text] [PDF]
|
|
|
|
 |
|
 P. Whiting, R. Harbord, C. Main, J. J Deeks, G. Filippini, M. Egger, and J. A C Sterne Accuracy of magnetic resonance imaging for the diagnosis of multiple sclerosis: systematic review BMJ, April 15, 2006; 332(7546): 875 - 884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Vrenken, S.A.R.B. Rombouts, P.J.W. Pouwels, and F. Barkhof Voxel-based analysis of quantitative T1 maps demonstrates that multiple sclerosis acts throughout the normal-appearing white matter. AJNR Am. J. Neuroradiol., April 1, 2006; 27(4): 868 - 874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Brettschneider, A Petzold, A Junker, and H Tumani Axonal damage markers in the cerebrospinal fluid of patients with clinically isolated syndrome improve predicting conversion to definite multiple sclerosis Multiple Sclerosis, April 1, 2006; 12(2): 143 - 148. [Abstract] [PDF]
|
|
|
|
|
|
A Theodoridou and L Settas Demyelination in rheumatic diseases. J. Neurol. Neurosurg. Psychiatry, March 1, 2006; 77(3): 290 - 295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Pittock, V. A. Lennon, K. Krecke, D. M. Wingerchuk, C. F. Lucchinetti, and B. G. Weinshenker Brain abnormalities in neuromyelitis optica. Arch Neurol, March 1, 2006; 63(3): 390 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Masjuan, J. C. Alvarez-Cermeno, N. Garcia-Barragan, M. Diaz-Sanchez, M. Espino, M. C. Sadaba, P. Gonzalez-Porque, J. M. San Millan, and L. M. Villar Clinically isolated syndromes: A new oligoclonal band test accurately predicts conversion to MS Neurology, February 28, 2006; 66(4): 576 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Barkhof, U. Held, J. H. Simon, M. Daumer, F. Fazekas, M. Filippi, J. A. Frank, L. Kappos, D. Li, S. Menzler, et al. Predicting gadolinium enhancement status in MS patients eligible for randomized clinical trials Neurology, November 8, 2005; 65(9): 1447 - 1454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S A Trip and D H Miller Imaging in multiple sclerosis J. Neurol. Neurosurg. Psychiatry, September 1, 2005; 76(suppl_3): iii11 - iii18. [Full Text] [PDF]
|
|
|
|
|
|
I F Pestalozza, C Pozzilli, S Di Legge, M C Piattella, P Pantano, F Caramia, P Pasqualetti, and G L Lenzi Monthly brain magnetic resonance imaging scans in patients with clinically isolated syndrome Multiple Sclerosis, August 1, 2005; 11(4): 390 - 394. [Abstract] [PDF]
|
|
|
|
 |
|
 J. J. G. Geurts, P. J. W. Pouwels, B. M. J. Uitdehaag, C. H. Polman, F. Barkhof, and J. A. Castelijns Intracortical Lesions in Multiple Sclerosis: Improved Detection with 3D Double Inversion-Recovery MR Imaging Radiology, July 1, 2005; 236(1): 254 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gallo, M. Rovaris, R. Riva, A. Ghezzi, B. Benedetti, V. Martinelli, A. Falini, G. Comi, and M. Filippi Diffusion-Tensor Magnetic Resonance Imaging Detects Normal-Appearing White Matter Damage Unrelated to Short-term Disease Activity in Patients at the Earliest Clinical Stage of Multiple Sclerosis Arch Neurol, May 1, 2005; 62(5): 803 - 808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Carmosino, K. M. Brousseau, D. B. Arciniegas, and J. R. Corboy Initial Evaluations for Multiple Sclerosis in a University Multiple Sclerosis Center: Outcomes and Role of Magnetic Resonance Imaging in Referral Arch Neurol, April 1, 2005; 62(4): 585 - 590. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ferreira, D. P. D'Cruz, and G. R. V. Hughes Multiple sclerosis, neuropsychiatric lupus and antiphospholipid syndrome: where do we stand? Rheumatology, April 1, 2005; 44(4): 434 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Laura, W. Leong, N. M.F. Murray, G. Ingle, K. A. Miszkiel, D. R. Altmann, D. H. Miller, and M. M. Reilly Chronic inflammatory demyelinating polyradiculoneuropathy: MRI study of brain and spinal cord Neurology, March 8, 2005; 64(5): 914 - 916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H Polman, J. S Wolinsky, and S. C Reingold Multiple sclerosis diagnostic criteria: three years later Multiple Sclerosis, February 1, 2005; 11(1): 5 - 12. [Abstract] [PDF]
|
|
|
|
|
|
R. Bakshi, G. J. Hutton, J. R. Miller, and E.-W. Radue The use of magnetic resonance imaging in the diagnosis and long-term management of multiple sclerosis Neurology, December 14, 2004; 63(11_suppl_5): S3 - S11. [Abstract] [Full Text]
|
|
|
|
|
|
W. H. Stuart, S. Cohan, J. R. Richert, and A. Achiron Selecting a disease-modifying agent as platform therapy in the long-term management of multiple sclerosis Neurology, December 14, 2004; 63(11_suppl_5): S19 - S27. [Abstract] [Full Text]
|
|
|
|
|
|
M Colucci, L Roccatagliata, E Capello, E Narciso, N Latronico, M Tabaton, and G L Mancardi The 14-3-3 protein in multiple sclerosis: a marker of disease severity Multiple Sclerosis, October 1, 2004; 10(5): 477 - 481. [Abstract] [PDF]
|
|
|
|
|
|
A. Kheradvar, A. R. Tabassi, B. Nikbin, F. Khosravi, M. Naroueynejad, B. Moradi, and A. A. Amirzargar Influence of HLA on progression of optic neuritis to multiple sclerosis: results of a four-year follow-up study Multiple Sclerosis, October 1, 2004; 10(5): 526 - 531. [Abstract] [PDF]
|
|
|
|
|
|
Optic Neuritis Study Group Long-term Brain Magnetic Resonance Imaging Changes After Optic Neuritis in Patients Without Clinically Definite Multiple Sclerosis Arch Neurol, October 1, 2004; 61(10): 1538 - 1541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. J. Uitdehaag, J. J. G. Geurts, F. Barkhof, C. H. Polman, D. S. Goodin, and E. M. Frohman The utility of MRI in suspected MS: Report of the Therapeutics and Technology Assessment Subcommittee Neurology, September 28, 2004; 63(6): 1140 - 1140. [Full Text] [PDF]
|
|
|
|
|
|
Y. Mikaeloff, C. Adamsbaum, B. Husson, L. Vallee, G. Ponsot, C. Confavreux, M. Tardieu, S. Suissa, and the KIDMUS Study Group on Radiology MRI prognostic factors for relapse after acute CNS inflammatory demyelination in childhood Brain, September 1, 2004; 127(9): 1942 - 1947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. T. M. Fernando, M. A. McLean, D. T. Chard, D. G. MacManus, C. M. Dalton, K. A. Miszkiel, R. M. Gordon, G. T. Plant, A. J. Thompson, and D. H. Miller Elevated white matter myo-inositol in clinically isolated syndromes suggestive of multiple sclerosis Brain, June 1, 2004; 127(6): 1361 - 1369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.-A. Laplaud, C. Ruiz, S. Wiertlewski, S. Brouard, L. Berthelot, M. Guillet, B. Melchior, N. Degauque, G. Edan, P. Brachet, et al. Blood T-cell receptor {beta} chain transcriptome in multiple sclerosis. Characterization of the T cells with altered CDR3 length distribution Brain, May 1, 2004; 127(5): 981 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Hahn, M. M. Shroff, S. I. Blaser, and B. L. Banwell MRI criteria for multiple sclerosis: Evaluation in a pediatric cohort Neurology, March 9, 2004; 62(5): 806 - 808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Goffette, M Schluep, H Henry, T Duprez, and C J M Sindic Detection of oligoclonal free kappa chains in the absence of oligoclonal IgG in the CSF of patients with suspected multiple sclerosis J. Neurol. Neurosurg. Psychiatry, February 1, 2004; 75(2): 308 - 310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Minneboo, F. Barkhof, C. H. Polman, B. M. J. Uitdehaag, D. L. Knol, and J. A. Castelijns Infratentorial Lesions Predict Long-term Disability in Patients With Initial Findings Suggestive of Multiple Sclerosis Arch Neurol, February 1, 2004; 61(2): 217 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sastre-Garriga, M. Tintore, A. Rovira, C. Nos, J. Rio, A. J. Thompson, and X. Montalban Specificity of Barkhof Criteria in Predicting Conversion to Multiple Sclerosis When Applied to Clinically Isolated Brainstem Syndromes Arch Neurol, February 1, 2004; 61(2): 222 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C.J. Bot, F. Barkhof, C. H. Polman, G.J. L. a Nijeholt, V. de Groot, E. Bergers, H. J. Ader, and J. A. Castelijns Spinal cord abnormalities in recently diagnosed MS patients: Added value of spinal MRI examination Neurology, January 27, 2004; 62(2): 226 - 233. [Abstract] [Full Text] [PDF]
|
|