Brain, Vol 120, Issue 3 393-399, Copyright © 1997 by Oxford University Press
B Ferguson, MK Matyszak, MM Esiri and VH Perry
One of the histological hallmarks of early multiple sclerosis lesions is
primary demyelination, with myelin destruction and relative sparing of
axons. On the other hand, it is widely accepted that axonal loss occurs in,
and is responsible for, the permanent disability characterizing the later
chronic progressive stage of the disease. In this study, we have used an
antibody against amyloid precursor protein, known to be a sensitive marker
of axonal damage in a number of other contexts, in immunocytochemical
experiments on paraffin embedded multiple sclerosis lesions of varying ages
in order to see at which stage of the disease axonal damage, in addition to
demyelination, occurs and may thus contribute to the development of
disability in patients. The results show the expression of amyloid
precursor protein in damaged axons within acute multiple sclerosis lesions,
and in the active borders of less acute lesions. This observation may have
implications for the design and timing of therapeutic intervention, one of
the most important aims of which must be the reduction of permanent
disability.
ARTICLES
Axonal damage in acute multiple sclerosis lesions
Department of Pharmacology, Oxford University, UK.
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