Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (151)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Samuel, M.
Right arrow Articles by Brooks, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Samuel, M.
Right arrow Articles by Brooks, D. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Brain, Vol 120, Issue 6 963-976, Copyright © 1997 by Oxford University Press

ARTICLES

Evidence for lateral premotor and parietal overactivity in Parkinson's disease during sequential and bimanual movements. A PET study

M Samuel, AO Ceballos-Baumann, J Blin, T Uema, H Boecker, RE Passingham and DJ Brooks
MRC Cyclotron Unit, Hammersmith Hospital, London, UK.

Patients with Parkinson's disease have great difficulty in performing sequential and bimanual movements. We used H2(15)O PET to study the regional cerebral blood flow associated with performance of sequential finger movements made unimanually and bimanually in a group of Parkinson's disease patients and a group of control volunteers. In controls, sequential finger movements led to activation of the contralateral motor cortex and inferior parietal cortex (Brodmann area 40), the lateral premotor cortex and bilateral supplementary motor area. No prefrontal activation was seen. Sequential finger movements in the Parkinson's disease group were associated with a similar pattern of activation but there was relative impairment of activation in the mesial frontal and prefrontal areas. A novel finding was the presence of relative overactivity in the lateral premotor and inferolateral parietal regions. We conclude that in Parkinson's disease there is a switch from the use of striato-mesial frontal to parietal-lateral premotor circuits in order to facilitate performance of complex finger movements.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cereb CortexHome page
R. C. Helmich, L. C. Derikx, M. Bakker, R. Scheeringa, B. R. Bloem, and I. Toni
Spatial Remapping of Cortico-striatal Connectivity in Parkinson's Disease
Cereb Cortex, August 26, 2009; (2009) bhp178v1.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
L. Zhang
Subclinical cortical reorganization: A preclinical imaging marker for recessively inherited PD?
Neurology, March 24, 2009; 72(12): 1036 - 1037.
[Full Text] [PDF]

Home page
 NeurologyHome page
B.F.L. van Nuenen, M. M. Weiss, B. R. Bloem, K. Reetz, T. van Eimeren, K. Lohmann, J. Hagenah, P. P. Pramstaller, F. Binkofski, C. Klein, et al.
Heterozygous carriers of a Parkin or PINK1 mutation share a common functional endophenotype
Neurology, March 24, 2009; 72(12): 1041 - 1047.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
K. Caeyenberghs, N. Wenderoth, B. C. M. Smits-Engelsman, S. Sunaert, and S. P. Swinnen
Neural correlates of motor dysfunction in children with traumatic brain injury: exploration of compensatory recruitment patterns
Brain, March 1, 2009; 132(3): 684 - 694.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
B Ballanger, P Baraduc, E Broussolle, D Le Bars, M Desmurget, and S Thobois
Motor urgency is mediated by the contralateral cerebellum in Parkinson's disease
J. Neurol. Neurosurg. Psychiatry, October 1, 2008; 79(10): 1110 - 1116.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
B Westermann, E Wattendorf, U Schwerdtfeger, A Husner, P Fuhr, O Gratzl, T Hummel, D Bilecen, and A Welge-Lussen
Functional imaging of the cerebral olfactory system in patients with Parkinson's disease
J. Neurol. Neurosurg. Psychiatry, January 1, 2008; 79(1): 19 - 24.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Akkal, R. P. Dum, and P. L. Strick
Supplementary Motor Area and Presupplementary Motor Area: Targets of Basal Ganglia and Cerebellar Output
J. Neurosci., October 3, 2007; 27(40): 10659 - 10673.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
E. D. Ross, C. I. Prodan, and M. Monnot
Human Facial Expressions Are Organized Functionally Across the Upper-Lower Facial Axis
Neuroscientist, October 1, 2007; 13(5): 433 - 446.
[Abstract] [PDF]

Home page
 BrainHome page
O. Monchi, M. Petrides, B. Mejia-Constain, and A. P. Strafella
Cortical activity in Parkinson's disease during executive processing depends on striatal involvement
Brain, January 1, 2007; 130(1): 233 - 244.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
S. T. Grafton, R. S. Turner, M. Desmurget, R. Bakay, M. Delong, J. Vitek, and M. Crutcher
Normalizing motor-related brain activity: Subthalamic nucleus stimulation in Parkinson disease
Neurology, April 25, 2006; 66(8): 1192 - 1199.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
N. Fogelson, D. Williams, M. Tijssen, G. van Bruggen, H. Speelman, and P. Brown
Different Functional Loops between Cerebral Cortex and the Subthalmic Area in Parkinson's Disease
Cereb Cortex, January 1, 2006; 16(1): 64 - 75.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
C. Buhmann, F. Binkofski, C. Klein, C. Buchel, T. van Eimeren, C. Erdmann, K. Hedrich, M. Kasten, J. Hagenah, G. Deuschl, et al.
Motor reorganization in asymptomatic carriers of a single mutant Parkin allele: a human model for presymptomatic parkinsonism
Brain, October 1, 2005; 128(10): 2281 - 2290.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
T. Wu and M. Hallett
A functional MRI study of automatic movements in patients with Parkinson's disease
Brain, October 1, 2005; 128(10): 2250 - 2259.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
P. Mir, K. Matsunaga, F. Gilio, N. P. Quinn, H. R. Siebner, and J. C. Rothwell
Dopaminergic drugs restore facilitatory premotor-motor interactions in Parkinson disease
Neurology, June 14, 2005; 64(11): 1906 - 1912.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
P. Silberstein, A. Pogosyan, A. A. Kuhn, G. Hotton, S. Tisch, A. Kupsch, P. Dowsey-Limousin, M. I. Hariz, and P. Brown
Cortico-cortical coupling in Parkinson's disease and its modulation by therapy
Brain, June 1, 2005; 128(6): 1277 - 1291.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
H. Johansen-Berg, T. E.J. Behrens, E. Sillery, O. Ciccarelli, A. J. Thompson, S. M. Smith, and P. M. Matthews
Functional-Anatomical Validation and Individual Variation of Diffusion Tractography-based Segmentation of the Human Thalamus
Cereb Cortex, January 1, 2005; 15(1): 31 - 39.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
C. Buhmann, A. Gorsler, T. Baumer, U. Hidding, C. Demiralay, K. Hinkelmann, C. Weiller, H. R. Siebner, and A. Munchau
Abnormal excitability of premotor-motor connections in de novo Parkinson's disease
Brain, December 1, 2004; 127(12): 2732 - 2746.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
P. Payoux, P. Remy, P. Damier, M. Miloudi, I. Loubinoux, B. Pidoux, V. Gaura, O. Rascol, Y. Samson, and Y. Agid
Subthalamic Nucleus Stimulation Reduces Abnormal Motor Cortical Overactivity in Parkinson Disease
Arch Neurol, August 1, 2004; 61(8): 1307 - 1313.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
O. Detante, L. Vercueil, S. Thobois, E. Broussolle, N. Costes, F. Lavenne, S. Chabardes, D. Lebars, M. Vidailhet, A.-L. Benabid, et al.
Globus pallidus internus stimulation in primary generalized dystonia: a H215O PET study
Brain, August 1, 2004; 127(8): 1899 - 1908.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
S. Pinto, S. Thobois, N. Costes, D. Le Bars, A.-L. Benabid, E. Broussolle, P. Pollak, and M. Gentil
Subthalamic nucleus stimulation and dysarthria in Parkinson's disease: a PET study
Brain, March 1, 2004; 127(3): 602 - 615.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
O. Monchi, M. Petrides, J. Doyon, R. B. Postuma, K. Worsley, and A. Dagher
Neural Bases of Set-Shifting Deficits in Parkinson's Disease
J. Neurosci., January 21, 2004; 24(3): 702 - 710.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. Kobayashi, S. Hutchinson, H. Theoret, G. Schlaug, and A. Pascual-Leone
Repetitive TMS of the motor cortex improves ipsilateral sequential simple finger movements
Neurology, January 13, 2004; 62(1): 91 - 98.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
G. Kleiner-Fisman, D. N. Fisman, F. I. Kahn, E. Sime, A. M. Lozano, and A. E. Lang
Motor Cortical Stimulation for Parkinsonism in Multiple System Atrophy
Arch Neurol, November 1, 2003; 60(11): 1554 - 1558.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. Grossman, A. Cooke, C. DeVita, C. Lee, D. Alsop, J. Detre, J. Gee, W. Chen, M. B. Stern, and H. I. Hurtig
Grammatical and resource components of sentence processing in Parkinson's disease: An fMRI study
Neurology, March 11, 2003; 60(5): 775 - 781.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. Liotti, L.O. Ramig, D. Vogel, P. New, C.I. Cook, R.J. Ingham, J.C. Ingham, and P.T. Fox
Hypophonia in Parkinson's disease: Neural correlates of voice treatment revealed by PET
Neurology, February 11, 2003; 60(3): 432 - 440.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
I. K. Goerendt, C. Messa, A. D. Lawrence, P. M. Grasby, P. Piccini, and D. J. Brooks
Dopamine release during sequential finger movements in health and Parkinson's disease: a PET study
Brain, February 1, 2003; 126(2): 312 - 325.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
L. Escola, Th. Michelet, F. Macia, D. Guehl, B. Bioulac, and P. Burbaud
Disruption of information processing in the supplementary motor area of the MPTP-treated monkey: A clue to the pathophysiology of akinesia?
Brain, January 1, 2003; 126(1): 95 - 114.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
U. Schroeder, A. Kuehler, B. Haslinger, P. Erhard, W. Fogel, V. M. Tronnier, K. W. Lange, H. Boecker, and A. O. Ceballos-Baumann
Subthalamic nucleus stimulation affects striato-anterior cingulate cortex circuit in a response conflict task: a PET study
Brain, September 1, 2002; 125(9): 1995 - 2004.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
D. Williams, M. Tijssen, G. van Bruggen, A. Bosch, A. Insola, V. D. Lazzaro, P. Mazzone, A. Oliviero, A. Quartarone, H. Speelman, et al.
Dopamine-dependent changes in the functional connectivity between basal ganglia and cerebral cortex in humans
Brain, July 1, 2002; 125(7): 1558 - 1569.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. Sawamoto, M. Honda, T. Hanakawa, H. Fukuyama, and H. Shibasaki
Cognitive Slowing in Parkinson's Disease: A Behavioral Evaluation Independent of Motor Slowing
J. Neurosci., June 15, 2002; 22(12): 5198 - 5203.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
S. Sestini, A. Scotto di Luzio, F. Ammannati, M. T. R. De Cristofaro, A. Passeri, S. Martini, and A. Pupi
Changes in Regional Cerebral Blood Flow Caused by Deep-Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease
J. Nucl. Med., June 1, 2002; 43(6): 725 - 732.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. A. Goldberg, T. Boraud, S. Maraton, S. N. Haber, E. Vaadia, and H. Bergman
Enhanced Synchrony among Primary Motor Cortex Neurons in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Primate Model of Parkinson's Disease
J. Neurosci., June 1, 2002; 22(11): 4639 - 4653.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. Rowe, K. E. Stephan, K. Friston, R. Frackowiak, A. Lees, and R. Passingham
Attention to action in Parkinson's disease: Impaired effective connectivity among frontal cortical regions
Brain, February 1, 2002; 125(2): 276 - 289.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
A. Berardelli, J. C. Rothwell, P. D. Thompson, and M. Hallett
Pathophysiology of bradykinesia in Parkinson's disease
Brain, November 1, 2001; 124(11): 2131 - 2146.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
W. Gerschlager, H. R. Siebner, and J. C. Rothwell
Decreased corticospinal excitability after subthreshold 1 Hz rTMS over lateral premotor cortex
Neurology, August 14, 2001; 57(3): 449 - 455.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
B. Haslinger, P. Erhard, N. Kampfe, H. Boecker, E. Rummeny, M. Schwaiger, B. Conrad, and A. O. Ceballos-Baumann
Event-related functional magnetic resonance imaging in Parkinson's disease before and after levodopa
Brain, March 1, 2001; 124(3): 558 - 570.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
S. Thobois, P. F. Dominey, J. Decety, P. Pollak, M. C. Gregoire, D. L. Bars, and E. Broussolle
Motor imagery in normal subjects and in asymmetrical Parkinson's disease: A PET study
Neurology, October 10, 2000; 55(7): 996 - 1002.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. A. Saint-Cyr, L. L. Trepanier, R. Kumar, A. M. Lozano, and A. E. Lang
Neuropsychological consequences of chronic bilateral stimulation of the subthalamic nucleus in Parkinson's disease
Brain, October 1, 2000; 123(10): 2091 - 2108.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P. van Donkelaar, J. F. Stein, R. E. Passingham, and R. C. Miall
Temporary Inactivation in the Primate Motor Thalamus During Visually Triggered and Internally Generated Limb Movements
J Neurophysiol, May 1, 2000; 83(5): 2780 - 2790.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
U. Sabatini, K. Boulanouar, N. Fabre, F. Martin, C. Carel, C. Colonnese, L. Bozzao, I. Berry, J. L. Montastruc, F. Chollet, et al.
Cortical motor reorganization in akinetic patients with Parkinson's disease: A functional MRI study
Brain, February 1, 2000; 123(2): 394 - 403.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
H. Boecker, A. Ceballos-Baumann, P. Bartenstein, A. Weindl, H. R. Siebner, T. Fassbender, F. Munz, M. Schwaiger, and B. Conrad
Sensory processing in Parkinson's and Huntington's disease: Investigations with 3D H215O-PET
Brain, September 1, 1999; 122(9): 1651 - 1665.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
A. O. Ceballos-Baumann, H. Boecker, P. Bartenstein, I. von Falkenhayn, H. Riescher, B. Conrad, J. R. Moringlane, and F. Alesch
A Positron Emission Tomographic Study of Subthalamic Nucleus Stimulation in Parkinson Disease: Enhanced Movement-Related Activity of Motor-Association Cortex and Decreased Motor Cortex Resting Activity
Arch Neurol, August 1, 1999; 56(8): 997 - 1003.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
T. Hanakawa, Y. Katsumi, H. Fukuyama, M. Honda, T. Hayashi, J. Kimura, and H. Shibasaki
Mechanisms underlying gait disturbance in Parkinson's disease: A single photon emission computed tomography study
Brain, July 1, 1999; 122(7): 1271 - 1282.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
S. Yazawa, A. Ikeda, R. Kaji, K. Terada, T. Nagamine, K.-i. Toma, T. Kubori, J. Kimura, and H. Shibasaki1
Abnormal cortical processing of voluntary muscle relaxation in patients with focal hand dystonia studied by movement-related potentials
Brain, July 1, 1999; 122(7): 1357 - 1366.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
T. E. Kimber, C. S. Tsai, J. Semmler, B. P. Brophy, and P. D. Thompson
Voluntary movement after pallidotomy in severe Parkinson's disease
Brain, May 1, 1999; 122(5): 895 - 906.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.