Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (281)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Kidd, D.
Right arrow Articles by Revesz, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kidd, D.
Right arrow Articles by Revesz, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Brain, Vol. 122, No. 1, 17-26, January 1999
© 1999 Oxford University Press

Cortical lesions in multiple sclerosis

D. Kidd1, F. Barkhof2, R. McConnell3, P. R. Algra2, I. V. Allen3 and T. Revesz1

1 The National Hospital for Neurology and Neurosurgery, London, UK, 2 Department of Radiology, Academic Hospital of the Vrije Universiteit, Amsterdam, The Netherlands and 3 Neuropathology Department, the Queen's University of Belfast, Northern Ireland

Correspondence to: Dr Tamas Revesz, Neuropathology Department, Institute of Neurology, Queen Square, London WC1N 3BG, UK

Although previous studies have shown that the lesions of multiple sclerosis may involve the cerebral cortex, there is little published research on the prevalence and distribution of such lesions. Using neuropathological techniques and MRI, a series of studies has been undertaken in order to assess this, in particular to identify their relationship to cortical veins. A serial MRI study showed that the use of gadolinium proffered an increase in cortical lesion detection of 140% and showed that 26% of active lesions arose within or adjacent to the cortex. In a post-mortem study, MRI under-reported lesions subsequently analysed neuropathologically, particularly those arising within the cortex. In a further 12 cases examined, 478 cortical lesions were identified, of which 372 also involved the subcortical white matter. Seven different lesion types were identified; the majority arose within the territory of the principal cortical veins, whilst the remaining quarter arose within the territory of the small branch or superficial veins. Small cortical lesions are common in multiple sclerosis and are under-reported by MRI. Investigation of the cortical venous supply shows how such lesions may arise, and why the majority also involve the underlying white matter.

multiple sclerosis; cortical lesions; neuropathology; MRI


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mult SclerHome page
G. W. Moore, A. M Vitali, E. Leung, C. Laule, P. Kozlowski, A. L MacKay, and C. R Honey
Thalamic stimulation in multiple sclerosis: evidence for a 'demyelinative thalamotomy'
Multiple Sclerosis, November 1, 2009; 15(11): 1311 - 1321.
[Abstract] [PDF]

Home page
 Cereb CortexHome page
S. Amadio, C. Montilli, R. Magliozzi, G. Bernardi, R. Reynolds, and C. Volonte
P2Y12 Receptor Protein in Cortical Gray Matter Lesions in Multiple Sclerosis
Cereb Cortex, September 26, 2009; (2009) bhp193v1.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
C. Mainero, T. Benner, A. Radding, A. van der Kouwe, R. Jensen, B. R. Rosen, and R. P. Kinkel
In vivo imaging of cortical pathology in multiple sclerosis using ultra-high field MRI
Neurology, September 22, 2009; 73(12): 941 - 948.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
M. Calabrese, F. Agosta, F. Rinaldi, I. Mattisi, P. Grossi, A. Favaretto, M. Atzori, V. Bernardi, L. Barachino, L. Rinaldi, et al.
Cortical Lesions and Atrophy Associated With Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis
Arch Neurol, September 1, 2009; 66(9): 1144 - 1150.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
M Calabrese and P Gallo
Magnetic resonance evidence of cortical onset of multiple sclerosis
Multiple Sclerosis, August 1, 2009; 15(8): 933 - 941.
[Abstract] [PDF]

Home page
 Am. J. Neuroradiol.Home page
F. Tovar-Moll, I.E. Evangelou, A.W. Chiu, N.D. Richert, J.L. Ostuni, J.M. Ohayon, S. Auh, M. Ehrmantraut, S.L. Talagala, H.F. McFarland, et al.
Thalamic Involvement and Its Impact on Clinical Disability in Patients with Multiple Sclerosis: A Diffusion Tensor Imaging Study at 3T
AJNR Am. J. Neuroradiol., August 1, 2009; 30(7): 1380 - 1386.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Derfuss, K. Parikh, S. Velhin, M. Braun, E. Mathey, M. Krumbholz, T. Kumpfel, A. Moldenhauer, C. Rader, P. Sonderegger, et al.
From the Cover: Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals
PNAS, May 19, 2009; 106(20): 8302 - 8307.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
L. Roccatagliata, L. Vuolo, L. Bonzano, A. Pichiecchio, and G. L. Mancardi
Multiple Sclerosis: Hyperintense Dentate Nucleus on Unenhanced T1-weighted MR Images Is Associated with the Secondary Progressive Subtype
Radiology, May 1, 2009; 251(2): 503 - 510.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. Calabrese, M. A. Rocca, M. Atzori, I. Mattisi, V. Bernardi, A. Favaretto, L. Barachino, C. Romualdi, L. Rinaldi, P. Perini, et al.
Cortical lesions in primary progressive multiple sclerosis: A 2-year longitudinal MR study
Neurology, April 14, 2009; 72(15): 1330 - 1336.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
P Zamboni, R Galeotti, E Menegatti, A M Malagoni, G Tacconi, S Dall'Ara, I Bartolomei, and F Salvi
Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis
J. Neurol. Neurosurg. Psychiatry, April 1, 2009; 80(4): 392 - 399.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
K. Kollia, S. Maderwald, N. Putzki, M. Schlamann, J.M. Theysohn, O. Kraff, M.E. Ladd, M. Forsting, and I. Wanke
First Clinical Study on Ultra-High-Field MR Imaging in Patients with Multiple Sclerosis: Comparison of 1.5T and 7T
AJNR Am. J. Neuroradiol., April 1, 2009; 30(4): 699 - 702.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
C. Gilmore, J. Geurts, N Evangelou, J. Bot, R. van Schijndel, P. Pouwels, F Barkhof, and L Bo
Spinal cord grey matter lesions in multiple sclerosis detected by post-mortem high field MR imaging
Multiple Sclerosis, February 1, 2009; 15(2): 180 - 188.
[Abstract] [PDF]

Home page
 Mult SclerHome page
G Tedeschi, D Dinacci, M Comerci, L Lavorgna, G Savettieri, A Quattrone, P Livrea, F Patti, V Brescia Morra, G Servillo, et al.
Brain atrophy evolution and lesion load accrual in multiple sclerosis: a 2-year follow-up study
Multiple Sclerosis, February 1, 2009; 15(2): 204 - 211.
[Abstract] [PDF]

Home page
 Mult SclerHome page
M Calabrese, M Filippi, M Rovaris, V Bernardi, M Atzori, I Mattisi, A Favaretto, P Grossi, L Barachino, L Rinaldi, et al.
Evidence for relative cortical sparing in benign multiple sclerosis: a longitudinal magnetic resonance imaging study
Multiple Sclerosis, January 1, 2009; 15(1): 36 - 41.
[Abstract] [PDF]

Home page
 Mult SclerHome page
F Nelson, A Poonawalla, P Hou, J. Wolinsky, and P. Narayana
3D MPRAGE improves classification of cortical lesions in multiple sclerosis
Multiple Sclerosis, November 1, 2008; 14(9): 1214 - 1219.
[Abstract] [PDF]

Home page
 BrainHome page
A. Chang, M. C. Smith, X. Yin, R. J. Fox, S. M. Staugaitis, and B. D. Trapp
Neurogenesis in the chronic lesions of multiple sclerosis
Brain, September 1, 2008; 131(9): 2366 - 2375.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. M. Anderson, D. W. Hampton, R. Patani, G. Pryce, R. A. Crowther, R. Reynolds, R. J. M. Franklin, G. Giovannoni, D. A. S. Compston, D. Baker, et al.
Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis
Brain, July 1, 2008; 131(7): 1736 - 1748.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. W. Chen, M. O. Breckwoldt, E. Aikawa, G. Chiang, and R. Weissleder
Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis
Brain, April 1, 2008; 131(4): 1123 - 1133.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
T. Skripuletz, M. Lindner, A. Kotsiari, N. Garde, J. Fokuhl, F. Linsmeier, C. Trebst, and M. Stangel
Cortical Demyelination Is Prominent in the Murine Cuprizone Model and Is Strain-Dependent
Am. J. Pathol., April 1, 2008; 172(4): 1053 - 1061.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
S. Mesaros, M. A. Rocca, M. Absinta, A. Ghezzi, N. Milani, L. Moiola, P. Veggiotti, G. Comi, and M. Filippi
Evidence of thalamic gray matter loss in pediatric multiple sclerosis
Neurology, March 25, 2008; 70(13_Part_2): 1107 - 1112.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
L. K. Fisniku, P. A. Brex, D. R. Altmann, K. A. Miszkiel, C. E. Benton, R. Lanyon, A. J. Thompson, and D. H. Miller
Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis
Brain, March 1, 2008; 131(3): 808 - 817.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
A. H. Poonawalla, K. M. Hasan, R. K. Gupta, C. W. Ahn, F. Nelson, J. S. Wolinsky, and P. A. Narayana
Diffusion-Tensor MR Imaging of Cortical Lesions in Multiple Sclerosis: Initial Findings
Radiology, March 1, 2008; 246(3): 880 - 886.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
H. Lassmann and C. F. Lucchinetti
Cortical demyelination in CNS inflammatory demyelinating diseases
Neurology, January 29, 2008; 70(5): 332 - 333.
[Full Text] [PDF]

Home page
 NeurologyHome page
N. M. Moll, A. M. Rietsch, A. J. Ransohoff, M. B. Cossoy, D. Huang, F. S. Eichler, B. D. Trapp, and R. M. Ransohoff
Cortical demyelination in PML and MS: Similarities and differences
Neurology, January 29, 2008; 70(5): 336 - 343.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
F. Nelson, A.H. Poonawalla, P. Hou, F. Huang, J.S. Wolinsky, and P.A. Narayana
Improved Identification of Intracortical Lesions in Multiple Sclerosis with Phase-Sensitive Inversion Recovery in Combination with Fast Double Inversion Recovery MR Imaging
AJNR Am. J. Neuroradiol., October 1, 2007; 28(9): 1645 - 1649.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
Z Khaleeli, J Sastre-Garriga, O Ciccarelli, D H Miller, and A J Thompson
Magnetisation transfer ratio in the normal appearing white matter predicts progression of disability over 1 year in early primary progressive multiple sclerosis
J. Neurol. Neurosurg. Psychiatry, October 1, 2007; 78(10): 1076 - 1082.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
M. Calabrese, N. De Stefano, M. Atzori, V. Bernardi, I. Mattisi, L. Barachino, A. Morra, L. Rinaldi, C. Romualdi, P. Perini, et al.
Detection of Cortical Inflammatory Lesions by Double Inversion Recovery Magnetic Resonance Imaging in Patients With Multiple Sclerosis
Arch Neurol, October 1, 2007; 64(10): 1416 - 1422.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
F. Agosta, E. Pagani, D. Caputo, and M. Filippi
Associations Between Cervical Cord Gray Matter Damage and Disability in Patients With Multiple Sclerosis
Arch Neurol, September 1, 2007; 64(9): 1302 - 1305.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
M. P. Amato, E. Portaccio, B. Goretti, V. Zipoli, M. Battaglini, M. L. Bartolozzi, M. L. Stromillo, L. Guidi, G. Siracusa, S. Sorbi, et al.
Association of Neocortical Volume Changes With Cognitive Deterioration in Relapsing-Remitting Multiple Sclerosis
Arch Neurol, August 1, 2007; 64(8): 1157 - 1161.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
F. Agosta, M. Absinta, M. P. Sormani, A. Ghezzi, A. Bertolotto, E. Montanari, G. Comi, and M. Filippi
In vivo assessment of cervical cord damage in MS patients: a longitudinal diffusion tensor MRI study
Brain, August 1, 2007; 130(8): 2211 - 2219.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
R. Dutta and B. D. Trapp
Pathogenesis of axonal and neuronal damage in multiple sclerosis
Neurology, May 29, 2007; 68(22_suppl_3): S22 - S31.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
R. Zivadinov
Can imaging techniques measure neuroprotection and remyelination in multiple sclerosis?
Neurology, May 29, 2007; 68(22_suppl_3): S72 - S82.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
B. Audoin, G. Davies, W. Rashid, L. Fisniku, A.J. Thompson, and D.H. Miller
Voxel-based analysis of grey matter magnetization transfer ratio maps in early relapsing remitting multiple sclerosis
Multiple Sclerosis, May 1, 2007; 13(4): 483 - 489.
[Abstract] [PDF]

Home page
 Mult SclerHome page
R. Zivadinov, L. Locatelli, D. Cookfair, B. Srinivasaraghavan, A. Bertolotto, M. Ukmar, A. Bratina, C. Maggiore, A. Bosco, A. Grop, et al.
I nterferon beta-1a slows progression of brain atrophy in relapsing-remitting multiple sclerosis predominantly by reducing gray matter atrophy
Multiple Sclerosis, May 1, 2007; 13(4): 490 - 501.
[Abstract] [PDF]

Home page
 BrainHome page
R. Magliozzi, O. Howell, A. Vora, B. Serafini, R. Nicholas, M. Puopolo, R. Reynolds, and F. Aloisi
Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology
Brain, April 1, 2007; 130(4): 1089 - 1104.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
I. Pirko, C. F. Lucchinetti, S. Sriram, and R. Bakshi
Gray matter involvement in multiple sclerosis
Neurology, February 27, 2007; 68(9): 634 - 642.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
A. Kangarlu, E.C. Bourekas, A. Ray-Chaudhury, and K.W. Rammohan
Cerebral Cortical Lesions in Multiple Sclerosis Detected by MR Imaging at 8 Tesla
AJNR Am. J. Neuroradiol., February 1, 2007; 28(2): 262 - 266.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M.P. Wattjes, G.G. Lutterbey, J. Gieseke, F. Traber, L. Klotz, S. Schmidt, and H.H. Schild
Double Inversion Recovery Brain Imaging at 3T: Diagnostic Value in the Detection of Multiple Sclerosis Lesions
AJNR Am. J. Neuroradiol., January 1, 2007; 28(1): 54 - 59.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
L. Bo, J. J. G. Geurts, P. van der Valk, C. Polman, and F. Barkhof
Lack of Correlation Between Cortical Demyelination and White Matter Pathologic Changes in Multiple Sclerosis
Arch Neurol, January 1, 2007; 64(1): 76 - 80.
[Abstract] [Full Text] [PDF]

Home page
 JRSMHome page
P. Zamboni
The Big Idea: Iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis
J R Soc Med, November 1, 2006; 99(11): 589 - 593.
[Full Text] [PDF]

Home page
 Mult SclerHome page
J H Simon
Brain atrophy in multiple sclerosis: what we know and would like to know
Multiple Sclerosis, November 1, 2006; 12(6): 679 - 687.
[Abstract] [PDF]

Home page
 Am. J. Neuroradiol.Home page
F. Bagnato, J.A. Butman, S. Gupta, M. Calabrese, L. Pezawas, J.M. Ohayon, F. Tovar-Moll, M. Riva, M.M. Cao, S.L. Talagala, et al.
In Vivo Detection of Cortical Plaques by MR Imaging in Patients with Multiple Sclerosis
AJNR Am. J. Neuroradiol., November 1, 2006; 27(10): 2161 - 2167.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. Rovaris, E. Judica, A. Gallo, B. Benedetti, M. P. Sormani, D. Caputo, A. Ghezzi, E. Montanari, A. Bertolotto, G. Mancardi, et al.
Grey matter damage predicts the evolution of primary progressive multiple sclerosis at 5 years
Brain, October 1, 2006; 129(10): 2628 - 2634.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
C. Wegner, M. M. Esiri, S. A. Chance, J. Palace, and P. M. Matthews
Neocortical neuronal, synaptic, and glial loss in multiple sclerosis.
Neurology, September 26, 2006; 67(6): 960 - 967.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
R. H. B. Benedict, J. M. Bruce, M. G. Dwyer, N. Abdelrahman, S. Hussein, B. Weinstock-Guttman, N. Garg, F. Munschauer, and R. Zivadinov
Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis.
Arch Neurol, September 1, 2006; 63(9): 1301 - 1306.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
J. Sepulcre, J. Sastre-Garriga, M. Cercignani, G. T. Ingle, D. H. Miller, and A. J. Thompson
Regional Gray Matter Atrophy in Early Primary Progressive Multiple Sclerosis: A Voxel-Based Morphometry Study.
Arch Neurol, August 1, 2006; 63(8): 1175 - 1180.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
D. Merkler, T. Ernsting, M. Kerschensteiner, W. Bruck, and C. Stadelmann
A new focal EAE model of cortical demyelination: multiple sclerosis-like lesions with rapid resolution of inflammation and extensive remyelination
Brain, August 1, 2006; 129(8): 1972 - 1983.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
Y. Ge
Multiple Sclerosis: The Role of MR Imaging
AJNR Am. J. Neuroradiol., June 1, 2006; 27(6): 1165 - 1176.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. Inglese
Multiple sclerosis: new insights and trends.
AJNR Am. J. Neuroradiol., May 1, 2006; 27(5): 954 - 957.
[Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
C.S. Yu, F.C. Lin, K.C. Li, T.Z. Jiang, C.Z. Zhu, W. Qin, H. Sun, and P. Chan
Diffusion tensor imaging in the assessment of normal-appearing brain tissue damage in relapsing neuromyelitis optica.
AJNR Am. J. Neuroradiol., May 1, 2006; 27(5): 1009 - 1015.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
C. Oreja-Guevara, A. Charil, D. Caputo, R. Cavarretta, M. P. Sormani, and M. Filippi
Magnetization transfer magnetic resonance imaging and clinical changes in patients with relapsing-remitting multiple sclerosis.
Arch Neurol, May 1, 2006; 63(5): 736 - 740.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
B. Audoin, K. T. M. Fernando, J. K. Swanton, A. J. Thompson, G. T. Plant, and D. H. Miller
Selective magnetization transfer ratio decrease in the visual cortex following optic neuritis
Brain, April 1, 2006; 129(4): 1031 - 1039.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
C. M. Dalton, K. A. Miszkiel, P. W. O'Connor, G. T. Plant, G.P.A. Rice, and D. H. Miller
Ventricular enlargement in MS: One-year change at various stages of disease
Neurology, March 14, 2006; 66(5): 693 - 698.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
L Ramio-Torrenta, J Sastre-Garriga, G T Ingle, G R Davies, V Ameen, D H Miller, and A J Thompson
Abnormalities in normal appearing tissues in early primary progressive multiple sclerosis and their relation to disability: a tissue specific magnetisation transfer study
J. Neurol. Neurosurg. Psychiatry, January 1, 2006; 77(1): 40 - 45.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
K. T. M. Fernando, D. J. Tozer, K. A. Miszkiel, R. M. Gordon, J. K. Swanton, C. M. Dalton, G. J. Barker, G. T. Plant, A. J. Thompson, and D. H. Miller
Magnetization transfer histograms in clinically isolated syndromes suggestive of multiple sclerosis
Brain, December 1, 2005; 128(12): 2911 - 2925.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
I. M. Pomeroy, P. M. Matthews, J. A. Frank, E. K. Jordan, and M. M. Esiri
Demyelinated neocortical lesions in marmoset autoimmune encephalomyelitis mimic those in multiple sclerosis
Brain, November 1, 2005; 128(11): 2713 - 2721.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
Z. Caramanos, S. Narayanan, and D. L. Arnold
1H-MRS quantification of tNA and tCr in patients with multiple sclerosis: a meta-analytic review
Brain, November 1, 2005; 128(11): 2483 - 2506.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
R. A. Bermel, S. R. Puli, R. A. Rudick, B. Weinstock-Guttman, E. Fisher, F. E. Munschauer III, and R. Bakshi
Prediction of Longitudinal Brain Atrophy in Multiple Sclerosis by Gray Matter Magnetic Resonance Imaging T2 Hypointensity
Arch Neurol, September 1, 2005; 62(9): 1371 - 1376.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
G. Tedeschi, L. Lavorgna, P. Russo, A. Prinster, D. Dinacci, G. Savettieri, A. Quattrone, P. Livrea, C. Messina, A. Reggio, et al.
Brain atrophy and lesion load in a large population of patients with multiple sclerosis
Neurology, July 26, 2005; 65(2): 280 - 285.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
J. J. G. Geurts, P. J. W. Pouwels, B. M. J. Uitdehaag, C. H. Polman, F. Barkhof, and J. A. Castelijns
Intracortical Lesions in Multiple Sclerosis: Improved Detection with 3D Double Inversion-Recovery MR Imaging
Radiology, July 1, 2005; 236(1): 254 - 260.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
G R Davies, D R Altmann, W Rashid, D T Chard, C M Griffin, G J Barker, R Kapoor, A J Thompson, and D H Miller
Emergence of thalamic magnetization transfer ratio abnormality in early relapsing--remitting multiple sclerosis
Multiple Sclerosis, June 1, 2005; 11(3): 276 - 281.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
M. Rovaris, A. Gallo, A. Falini, B. Benedetti, P. Rossi, M. Comola, G. Scotti, G. Comi, and M. Filippi
Axonal Injury and Overall Tissue Loss Are Not Related in Primary Progressive Multiple Sclerosis
Arch Neurol, June 1, 2005; 62(6): 898 - 902.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. Sastre-Garriga, G. T. Ingle, D. T. Chard, M. Cercignani, L. Ramio-Torrenta, D. H. Miller, and A. J. Thompson
Grey and white matter volume changes in early primary progressive multiple sclerosis: a longitudinal study
Brain, June 1, 2005; 128(6): 1454 - 1460.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
A. Gallo, M. Rovaris, R. Riva, A. Ghezzi, B. Benedetti, V. Martinelli, A. Falini, G. Comi, and M. Filippi
Diffusion-Tensor Magnetic Resonance Imaging Detects Normal-Appearing White Matter Damage Unrelated to Short-term Disease Activity in Patients at the Earliest Clinical Stage of Multiple Sclerosis
Arch Neurol, May 1, 2005; 62(5): 803 - 808.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
J. Sastre-Garriga, G. T. Ingle, D. T. Chard, Li. Ramio-Torrenta, M. A. McLean, D. H. Miller, and A. J. Thompson
Metabolite Changes in Normal-Appearing Gray and White Matter Are Linked With Disability in Early Primary Progressive Multiple Sclerosis
Arch Neurol, April 1, 2005; 62(4): 569 - 573.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
C. Oreja-Guevara, M. Rovaris, G. Iannucci, P. Valsasina, D. Caputo, R. Cavarretta, M. P. Sormani, P. Ferrante, G. Comi, and M. Filippi
Progressive Gray Matter Damage in Patients With Relapsing-Remitting Multiple Sclerosis: A Longitudinal Diffusion Tensor Magnetic Resonance Imaging Study
Arch Neurol, April 1, 2005; 62(4): 578 - 584.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. Tiberio, D. T. Chard, D. R. Altmann, G. Davies, C. M. Griffin, W. Rashid, J. Sastre-Garriga, A. J. Thompson, and D. H. Miller
Gray and white matter volume changes in early RRMS: A 2-year longitudinal study
Neurology, March 22, 2005; 64(6): 1001 - 1007.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
J. J. G. Geurts, L. Bo, P. J. W. Pouwels, J. A. Castelijns, C. H. Polman, and F. Barkhof
Cortical Lesions in Multiple Sclerosis: Combined Postmortem MR Imaging and Histopathology
AJNR Am. J. Neuroradiol., March 1, 2005; 26(3): 572 - 577.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
J.-P. Ranjeva, B. Audoin, M. Van Au Duong, D. Ibarrola, S. Confort-Gouny, I. Malikova, E. Soulier, P. Viout, A. Ali-Cherif, J. Pelletier, et al.
Local Tissue Damage Assessed with Statistical Mapping Analysis of Brain Magnetization Transfer Ratio: Relationship with Functional Status of Patients in the Earliest Stage of Multiple Sclerosis
AJNR Am. J. Neuroradiol., January 1, 2005; 26(1): 119 - 127.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
M R Haupts, S Daum, G Ahle, B Holinka, and W Gehlen
Transcranial magnetic stimulation as a provocation for epileptic seizures in multiple sclerosis
Multiple Sclerosis, August 1, 2004; 10(4): 475 - 476.
[Abstract] [PDF]

Home page
 NeurologyHome page
M. P. Amato, M. L. Bartolozzi, V. Zipoli, E. Portaccio, M. Mortilla, L. Guidi, G. Siracusa, S. Sorbi, A. Federico, and N. De Stefano
Neocortical volume decrease in relapsing-remitting MS patients with mild cognitive impairment
Neurology, July 13, 2004; 63(1): 89 - 93.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
G R Davies, L Ramio-Torrenta, A Hadjiprocopis, D T Chard, C M B Griffin, W Rashid, G J Barker, R Kapoor, A J Thompson, and D H Miller
Evidence for grey matter MTR abnormality in minimally disabled patients with early relapsing-remitting multiple sclerosis
J. Neurol. Neurosurg. Psychiatry, July 1, 2004; 75(7): 998 - 1002.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
C. Lucchinetti and W. Bruck
The pathology of primary progressive multiple sclerosis
Multiple Sclerosis, June 1, 2004; 10(1_suppl): S23 - S30.
[Abstract] [PDF]

Home page
 BrainHome page
C. M. Dalton, D. T. Chard, G. R. Davies, K. A. Miszkiel, D. R. Altmann, K. Fernando, G. T. Plant, A. J. Thompson, and D. H. Miller
Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes
Brain, May 1, 2004; 127(5): 1101 - 1107.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
C. Lucchinetti and W. Bruck
The pathology of primary progressive multiple sclerosis
Multiple Sclerosis, May 1, 2004; 10(3_suppl): S23 - S30.
[Abstract] [PDF]

Home page
 NeurologyHome page
A. Feinstein, P. Roy, N. Lobaugh, K. Feinstein, P. O'Connor, and S. Black
Structural brain abnormalities in multiple sclerosis patients with major depression
Neurology, February 24, 2004; 62(4): 586 - 590.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
M. C. Tartaglia, S. Narayanan, S. J. Francis, A. C. Santos, N. De Stefano, Y. Lapierre, and D. L. Arnold
The Relationship Between Diffuse Axonal Damage and Fatigue in Multiple Sclerosis
Arch Neurol, February 1, 2004; 61(2): 201 - 207.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
A Traboulsee, J Dehmeshki, K. R Peters, C M Griffin, P A Brex, N Silver, O Ciccarrelli, D T Chard, G J Barker, A J Thompson, et al.
Disability in multiple sclerosis is related to normal appearing brain tissue MTR histogram abnormalities
Multiple Sclerosis, December 1, 2003; 9(6): 566 - 573.
[Abstract] [PDF]

Home page
 Mult SclerHome page
L Bo, C A Vedeler, H Nyland, B D Trapp, and S J Mork
Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration
Multiple Sclerosis, August 1, 2003; 9(4): 323 - 331.
[Abstract] [PDF]

Home page
 BrainHome page
M. Sailer, B. Fischl, D. Salat, C. Tempelmann, M. A. Schonfeld, E. Busa, N. Bodammer, H.-J. Heinze, and A. Dale
Focal thinning of the cerebral cortex in multiple sclerosis
Brain, August 1, 2003; 126(8): 1734 - 1744.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
M Zarei, S Chandran, A Compston, and J Hodges
Cognitive presentation of multiple sclerosis: evidence for a cortical variant
J. Neurol. Neurosurg. Psychiatry, July 1, 2003; 74(7): 872 - 877.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. Wylezinska, A. Cifelli, P. Jezzard, J. Palace, M. Alecci, and P. M. Matthews
Thalamic neurodegeneration in relapsing-remitting multiple sclerosis
Neurology, June 24, 2003; 60(12): 1949 - 1954.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
N. De Stefano, P. M. Matthews, M. Filippi, F. Agosta, M. De Luca, M. L. Bartolozzi, L. Guidi, A. Ghezzi, E. Montanari, A. Cifelli, et al.
Evidence of early cortical atrophy in MS: Relevance to white matter changes and disability
Neurology, April 8, 2003; 60(7): 1157 - 1162.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
B. Turner, X. Lin, G. Calmon, N. Roberts, and L. D Blumhardt
C erebral atrophy and disability in relapsing-remitting and secondary progressive multiple sclerosis over four years
Multiple Sclerosis, February 1, 2003; 9(1): 21 - 27.
[Abstract] [PDF]

Home page
 BrainHome page
D. T. Chard, C. M. Griffin, M. A. McLean, P. Kapeller, R. Kapoor, A. J. Thompson, and D. H. Miller
Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosis
Brain, October 1, 2002; 125(10): 2342 - 2352.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
M. Rovaris, M. Bozzali, G. Iannucci, A. Ghezzi, D. Caputo, E. Montanari, A. Bertolotto, R. Bergamaschi, R. Capra, G. L. Mancardi, et al.
Assessment of Normal-Appearing White and Gray Matter in Patients With Primary Progressive Multiple Sclerosis: A Diffusion-Tensor Magnetic Resonance Imaging Study
Arch Neurol, September 1, 2002; 59(9): 1406 - 1412.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
D. H. Miller, F. Barkhof, J. A. Frank, G. J. M. Parker, and A. J. Thompson
Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspects and clinical relevance
Brain, August 1, 2002; 125(8): 1676 - 1695.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. Bozzali, M. Cercignani, M. P. Sormani, G. Comi, and M. Filippi
Quantification of Brain Gray Matter Damage in Different MS Phenotypes by Use of Diffusion Tensor MR Imaging
AJNR Am. J. Neuroradiol., June 1, 2002; 23(6): 985 - 988.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
A Cifelli and P M Matthews
Cerebral plasticity in multiple sclerosis: insights from fMRI
Multiple Sclerosis, June 1, 2002; 8(3): 193 - 199.
[Abstract] [PDF]

Home page
 Mult SclerHome page
P Kapeller, P A Brex, D Chard, C Dalton, C M Griffin, M A McLean, G J. Parker, A J Thompson, and D H Miller
Quantitative 1H MRS imaging 14 years after presenting with a clinically isolated syndrome suggestive of multiple sclerosis
Multiple Sclerosis, June 1, 2002; 8(3): 207 - 210.
[Abstract] [PDF]

Home page
 Mult SclerHome page
C M Griffin, J Dehmeshki, D T Chard, G J. Parker, G J Barker, A J Thompson, and D H Miller
T1 histograms of normal-appearing brain tissue are abnormal in early relapsing-remitting multiple sclerosis
Multiple Sclerosis, June 1, 2002; 8(3): 211 - 216.
[Abstract] [PDF]

Home page
 NeurologyHome page
M. Filippi and R. I. Grossman
MRI techniques to monitor MS evolution: The present and the future
Neurology, April 23, 2002; 58(8): 1147 - 1153.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
M E Morris, C Cantwell, L Vowels, and K Dodd
Changes in gait and fatigue from morning to afternoon in people with multiple sclerosis
J. Neurol. Neurosurg. Psychiatry, March 1, 2002; 72(3): 361 - 365.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
D. T. Chard, C. M. Griffin, G. J. M. Parker, R. Kapoor, A. J. Thompson, and D. H. Miller
Brain atrophy in clinically early relapsing-remitting multiple sclerosis
Brain, February 1, 2002; 125(2): 327 - 337.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.