Brain, Vol. 122, No. 1, 3-4,
January 1999
© 1999 Oxford University Press
Editorial |
Another autoantibody in paraneoplastic neurological disease
Neurosciences Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
Paraneoplastic neurological syndromes (PNS) are an uncommon group of disorders caused by immune responses primarily directed against an underlying neoplasm that cross-react with proteins expressed in the peripheral or central nervous system. Understanding the relationship between expression of specific proteins in the tumour and the autoimmune neurological disease with which they associate is an ongoing challenge.
PNS are frequently associated with the presence of specific serum autoantibodies, which may be used as a diagnostic aid. For example, anti-Hu (also called anti-neuronal nuclear antibody 1, ANNA-1) is an antibody detected in the sera of patients with
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