Brain, Vol. 122, No. 10, 1901-1917,
October 1999
© 1999 Oxford University Press
Explicit and implicit processing of words and pseudowords by adult developmental dyslexics
A search for Wernicke's Wortschatz?
.
1 Wellcome Department of Cognitive Neurology, Institute of Neurology and 2 Institute of Cognitive Neuroscience, University College London, UK
Correspondence to:
Dr C. Price, Wellcome Department of Cognitive Neurology, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK E-mail: c.price{at}fil.ion.ucl.ac.uk
Two groups of male university students who had been diagnosed as dyslexic when younger, and two groups of control subjects of similar age and IQ to the dyslexics, were scanned whilst reading aloud and during a task where reading was implicit. The dyslexics performed less well than their peers on a range of literacy tasks and were strikingly impaired on phonological tasks. In the reading aloud experiment, simple words and pseudowords were presented at a slow pace so that reading accuracy was equal for dyslexics and controls. Relative to rest, both normal and dyslexic groups activated the same peri- and extra-sylvian regions of the left hemisphere that are known to be involved in reading. However, the dyslexic readers showed less activation than controls in the left posterior inferior temporal cortex [Brodmann area (BA) 37, or Wernicke's Wortschatz], left cerebellum, left thalamus and medial extrastriate cortex. In the implicit reading experiment, word and pseudoword processing was contrasted to visually matched false fonts while subjects performed a feature detection paradigm. The dyslexic readers showed reduced activation in BA 37 relative to normals suggesting that this group difference, seen in both experiments, resides in highly automated aspects of the reading process. Since BA 37 has been implicated previously in modality-independent naming, the reduced activation may indicate a specific impairment in lexical retrieval. Interestingly, during the reading aloud experiment only, there was increased activation for the dyslexics relative to the controls in a pre-motor region of Broca's area (BA 6/44). We attribute this result to the enforced use of an effortful compensatory strategy involving sublexical assembly of articulatory routines. The results confirm previous findings that dyslexic readers process written stimuli atypically, based on abnormal functioning of the left hemisphere reading system. More specifically, we localize this deficit to the neural system underlying lexical retrieval.
dyslexia; phonological deficit; explicit reading; implicit reading; word sound
BA = Brodmann area; NART = National Adult Reading Test; rCBF = regional cerebral blood flow; SPM = statistical parametric mapping; WRAT = Wide Range Achievement Test—Revised; WAIS-R = Wechsler Adult Intelligence Scale—Revised
* Present address: Department of Epidemiology and Public Health Medicine, UCL Medical School, 1–19 Torrington Place, London WC1E 6BT, UK
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