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Brain, Vol. 122, No. 2, 369-370, February 1999
© 1999 Oxford University Press

Book Reviews

HEADACHE PATHOGENESIS. Volume 7.MONOAMINES, NEUROPEPTIDES, PURINES, AND NITRIC OXIDE.

By Jes Olesen and Lars Edvinsson.1997. Pp. 352. Philadelphia: Lippincott-Raven.Price £72.50. ISBN 7-7817-1208-4..

H. Markus

Department of Clinical Neurosciences, King's College School of Medicine and the Institute of Psychiatry, London, UK

The aim of this book is to bring together available knowledge, much of it recent, about messenger molecules and their receptors involved in primary headaches. Individual chapters are summaries of platform presentations or posters presented at a recent international headache research seminar. These are divided into sections covering messenger molecules in relation to the blood vessels themselves, the role of such molecules in pain processing and the evidence linking amines and amino acids, neuropeptides and nitric oxide (NO) respectively, in the pathogenesis of migraine.

The first messenger molecule to be implicated in migraine was 5-hydroxytryptamine (5-HT). Blood 5-HT levels decrease during a migraine attack and this prompted the search for 5-HT receptor antagonists . . . [Full Text of this Article]


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