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Brain, Vol. 122, No. 6, 1063-1068, June 1999
© 1999 Oxford University Press

Classification learning in Alzheimer's disease

Szabolcs Kéri1,2, János Kálmán1, Steven Z. Rapcsak3,4, Andrea Antal2, György Benedek2 and Zoltán Janka1

1 Departments of Psychiatry and 2 Physiology, Albert Szent-Györgyi Medical University, Szeged, Hungary and 3 Neurology Section, VA Medical Center and 4 Department of Neurology, University of Arizona, Tucson, Arizona, USA

Correspondence to: Szabolcs Kéri, MD, Albert Szent-Györgyi Medical University, Department of Psychiatry, Szeged, 6701, Pf.397, Hungary E-mail: SZKERI{at}Phys.SZOTE.U.-Szeged.HU

Previous research has demonstrated that explicit recognition of dot patterns is impaired in amnesic patients with damage to the limbic–diencephalic memory system, while implicit categorization of the same kind of stimuli is preserved. The aim of the present study was to investigate the relationship between recognition and categorization performances in patients with Alzheimer's disease. Consistent with the findings in amnesic subjects, our results revealed that the explicit recognition of dot patterns was significantly impaired in Alzheimer's disease. However, implicit categorization functions were also disrupted. This was selective for the prototype stimuli; the categorization of non-prototype dot patterns was spared. The impaired category learning is likely to reflect the damage of modality-specific neocortical areas in Alzheimer's disease.

Alzheimer's disease; classification learning; non-declarative memory; prototype

ANOVA = analysis of variance


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