Brain, Vol. 122, No. 7, 1317-1325,
July 1999
© 1999 Oxford University Press
Semantic integration in reading: engagement of the right hemisphere during discourse processing
University of California, San Diego, USA
Correspondence to:
Marie St George, Center for Research in Language, 0526, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0526, USA E-mail: stgeorge{at}crl.ucsd.edu
We examined the brain areas involved in discourse processing by using functional MRI in 10 individuals as they read paragraphs, with or without a title, word by word for comprehension. Functional data were collected from 20 adjacent 5 mm axial slices. Discourse processing was associated with activation in inferior frontal and temporal regions of both cerebral hemispheres in the titled and untitled conditions. Moreover, there was substantially more right hemisphere activation for untitled than for the titled paragraphs. More specifically we found: (i) greater activation in the inferior temporal sulcus of both hemispheres for untitled than titled paragraphs; (ii) greater average volume of activation in response to untitled than titled paragraphs in the middle temporal sulcus of the right hemisphere and the reverse pattern in the left middle temporal sulcus. Consistent with previous studies of individuals with right hemisphere damage, we suggest that the right middle temporal regions may be especially important for integrative processes needed to achieve global coherence during discourse processing.
functional MRI; language; semantic integration; right hemisphere
BA = Brodmann area; ERP = event-related brain potential; fMRI = functional MRI
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