Brain, Vol. 122, No. 7, 1357-1366,
July 1999
© 1999 Oxford University Press
Abnormal cortical processing of voluntary muscle relaxation in patients with focal hand dystonia studied by movement-related potentials
1 Departments of Brain Pathophysiology 2 Neurology, Kyoto University School of Medicine and 3 Department of Neurology, Miyazaki Prefectural Hospital of Nobeoka, Japan.
Correspondence to:
Dr Hiroshi Shibasaki, Department of Brain Pathophysiology, Kyoto University School of Medicine, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan E-mail: shib{at}kuhp.kyoto-u.ac.jp
In order to clarify the abnormality in cortical motor preparation for voluntary muscle relaxation of the hand in patients with focal hand dystonia, Bereitschaftspotentials (BPs) preceding voluntary muscle contraction and relaxation were recorded in eight patients (three with simple writer's cramp and five with dystonic writer's cramp), and were compared with those from 10 normal subjects. Voluntary muscle relaxation: after keeping the right wrist in an extended position for > 5 s, the subject let the hand drop by voluntarily terminating muscle contraction of the wrist extensor without any associated muscle contraction. Voluntary muscle contraction: the right wrist was flexed by voluntarily contracting the wrist flexor muscle. Scalp EEGs were recorded from 11 electrodes placed over the frontal, central and parietal areas. In the control group, the BP measured at the movement onset was maximal at the left central area (C1), and distributed predominantly over the left hemisphere equally in both the contraction and relaxation tasks. In the focal hand dystonia group, BP was maximal at C1 in the contraction task, whereas, in the relaxation task, it was maximal at the midline central area (Cz) and symmetrically distributed. At the left central area, the BP amplitude in the focal hand dystonia group was diminished significantly in the relaxation task compared with the contraction task (P < 0.05). The present results demonstrate for the first time that the cortical preparatory process for voluntary muscle relaxation, or motor inhibition, is abnormal in focal hand dystonia.
focal hand dystonia; central motor control; voluntary muscle relaxation; movement-related cortical potential
ANOVA = analysis of variance; BP = Bereitschaftspotential; MP = motor potential; MRCP = movement-related cortical potential; SI–MI = primary sensorimotor cortex; SMA = supplementary motor area; TMS = transcranial magnetic stimulation
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