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Brain, Vol. 122, No. 8, 1401-1402, August 1999
© 1999 Oxford University Press

Editorial

`Like a thief in the night' : the selectivity of degeneration in Parkinson's disease

Clifford B. Saper

Department of Neurology and Program in Neuroscience,Harvard Medical School,Beth Israel Deaconess Medical Center,Boston, USA

The specificity by which neurological degenerative disorders can ravage one population of neurons, and yet leave the adjacent groups of cells undamaged, far exceeds the capability of even the smartest laser-guided bomb. The mechanism for this extraordinary specificity has long fascinated neurologists, but real progress has often come only with the development of chemical markers for specific subsets of neurons that degenerate in particular diseases. In the absence of such markers, the first attempts to identify the specific neurons whose loss results in the symptoms of Parkinson's disease were largely unsuccessful. Lewy, for example, described the intracellular inclusion that bears his name in degenerating neurons in the basal forebrain, but never focused upon the substantia nigra . . . [Full Text of this Article]

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