Brain, Vol. 122, No. 9, 1781-1790,
September 1999
© 1999 Oxford University Press
Training-induced brain plasticity in aphasia
1 Department of Neurology, Friedrich-Schiller-Universität Jena, 2 Department of Nuclear Medicine, Universität Essen and 3 Neurorehabilitationsklinik, Waldbreitbach, Germany
Correspondence to:
Dr Mariacristina Musso, Department of Neurology, Friedrich-Schiller University, Jena, Philosophenweg 3, 07740 Jena, Germany E-mail: musso{at}neuro.uni-jena.de
It has long been a matter of debate whether recovery from aphasia after left perisylvian lesions is mediated by the preserved left hemispheric language zones or by the homologous right hemisphere regions. Using PET, we investigated the short-term changes in the cortical network involved in language comprehension during recovery from aphasia. In 12 consecutive measurements of regional cerebral blood flow (rCBF), four patients with Wernicke's aphasia, caused by a posterior left middle cerebral artery infarction, were tested with a language comprehension task. Comprehension was estimated directly after each scan with a modified version of the Token Test. In the interval between the scans, the patients participated in brief, intense language comprehension training. A significant improvement in performance was observed in all patients. We correlated changes in blood flow measured during the language comprehension task with the scores achieved in the Token Test. The regions which best correlated with the training-induced improvement in verbal comprehension were the posterior part of the right superior temporal gyrus and the left precuneus. This study supports the role of the right hemisphere in recovery from aphasia and demonstrates that the improvement in auditory comprehension induced by specific training is associated with functional brain reorganization.
PET; recovery; stroke; aphasia
rCBF = regional cerebral blood flow; sTT = short version of the Token Test; TT = Token Test
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Richter, W. H. R. Miltner, and T. Straube Association between therapy outcome and right-hemispheric activation in chronic aphasia Brain, May 1, 2008; 131(5): 1391 - 1401. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Raymer, P. Beeson, A. Holland, D. Kendall, L. M. Maher, N. Martin, L. Murray, M. Rose, C. K. Thompson, L. Turkstra, et al. Translational Research in Aphasia: From Neuroscience to Neurorehabilitation J Speech Lang Hear Res, February 1, 2008; 51(1): S259 - S275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Nelissen, M. Vandenbulcke, K. Fannes, A. Verbruggen, R. Peeters, P. Dupont, K. Van Laere, G. Bormans, and R. Vandenberghe A{beta} amyloid deposition in the language system and how the brain responds Brain, August 1, 2007; 130(8): 2055 - 2069. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Winhuisen, A. Thiel, B. Schumacher, J. Kessler, J. Rudolf, W. F. Haupt, and W. D. Heiss The Right Inferior Frontal Gyrus and Poststroke Aphasia: A Follow-Up Investigation Stroke, April 1, 2007; 38(4): 1286 - 1292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Vitali, J. Abutalebi, M. Tettamanti, M. Danna, A.-I. Ansaldo, D. Perani, Y. Joanette, and S. F. Cappa Training-Induced Brain Remapping in Chronic Aphasia: A Pilot Study Neurorehabil Neural Repair, March 1, 2007; 21(2): 152 - 160. [Abstract] [PDF]
|
|
|
|
|
|
J. T. Devlin and K. E. Watkins Stimulating language: insights from TMS Brain, March 1, 2007; 130(3): 610 - 622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Smits, E. Visch-Brink, C. K. Schraa-Tam, P. J. Koudstaal, and A. van der Lugt Functional MR Imaging of Language Processing: An Overview of Easy-to-Implement Paradigms for Patient Care and Clinical Research RadioGraphics, October 1, 2006; 26(suppl_1): S145 - S158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Hillis The right place at the right time? Brain, June 1, 2006; 129(6): 1351 - 1356. [Full Text] [PDF]
|
|
|
|
|
|
D. Saur, R. Lange, A. Baumgaertner, V. Schraknepper, K. Willmes, M. Rijntjes, and C. Weiller Dynamics of language reorganization after stroke Brain, June 1, 2006; 129(6): 1371 - 1384. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G.S. Harrington, M.H. Buonocore, and S. T. Farias Intrasubject reproducibility of functional MR imaging activation in language tasks. AJNR Am. J. Neuroradiol., April 1, 2006; 27(4): 938 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-D. Heiss and R. W. Teasel Brain Recovery and Rehabilitation Stroke, February 1, 2006; 37(2): 314 - 316. [Full Text] [PDF]
|
|
|
|
|
|
B. H. Dobkin Rehabilitation and Functional Neuroimaging Dose-Response Trajectories for Clinical Trials Neurorehabil Neural Repair, December 1, 2005; 19(4): 276 - 282. [Abstract] [PDF]
|
|
|
|
|
|
J. Crinion and C. J. Price Right anterior superior temporal activation predicts auditory sentence comprehension following aphasic stroke Brain, December 1, 2005; 128(12): 2858 - 2871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M Schwartz, H. P Stapp, and M. Beauregard Quantum physics in neuroscience and psychology: a neurophysical model of mind-brain interaction Phil Trans R Soc B, June 29, 2005; 360(1458): 1309 - 1327. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. H. Dobkin Rehabilitation after Stroke N. Engl. J. Med., April 21, 2005; 352(16): 1677 - 1684. [Full Text] [PDF]
|
|
|
|
 |
|
 J.-F. Demonet, G. Thierry, and D. Cardebat Renewal of the Neurophysiology of Language: Functional Neuroimaging Physiol Rev, January 1, 2005; 85(1): 49 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gil and M. Goral Nonparallel recovery in bilingual aphasia: Effects of language choice, language proficiency, and treatment International Journal of Bilingualism, June 1, 2004; 8(2): 191 - 219. [Abstract] [PDF]
|
|
|
|
|
|
K. K. Peck, A. B. Moore, B. A. Crosson, M. Gaiefsky, K. S. Gopinath, K. White, and R. W. Briggs Functional Magnetic Resonance Imaging Before and After Aphasia Therapy: Shifts in Hemodynamic Time to Peak During an Overt Language Task Stroke, February 1, 2004; 35(2): 554 - 559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Cardebat, J.-F. Demonet, X. de Boissezon, N. Marie, R.-M. Marie, J. Lambert, J.-C. Baron, and M. Puel Behavioral and Neurofunctional Changes Over Time in Healthy and Aphasic Subjects: A PET Language Activation Study Stroke, December 1, 2003; 34(12): 2900 - 2906. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H Duffau, L Capelle, D Denvil, N Sichez, P Gatignol, M Lopes, M-C Mitchell, J-P Sichez, and R Van Effenterre Functional recovery after surgical resection of low grade gliomas in eloquent brain: hypothesis of brain compensation J. Neurol. Neurosurg. Psychiatry, July 1, 2003; 74(7): 901 - 907. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J S Wise Language systems in normal and aphasic human subjects: functional imaging studies and inferences from animal studies Br. Med. Bull., March 1, 2003; 65(1): 95 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Duffau, D Denvil, and L Capelle Long term reshaping of language, sensory, and motor maps after glioma resection: a new parameter to integrate in the surgical strategy J. Neurol. Neurosurg. Psychiatry, April 1, 2002; 72(4): 511 - 516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Pulvermuller, B. Neininger, T. Elbert, B. Mohr, B. Rockstroh, P. Koebbel, and E. Taub Constraint-Induced Therapy of Chronic Aphasia After Stroke Stroke, July 1, 2001; 32(7): 1621 - 1626. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Papanicolaou, P. G. Simos, J. I. Breier, J. W. Wheless, P. Mancias, J. E. Baumgartner, W. W. Maggio, W. Gormley, J. E.C. Constantinou, and I. I. Butler Brain Plasticity for Sensory and Linguistic Functions: A Functional Imaging Study Using Magnetoencephalography With Children and Young Adults J Child Neurol, April 1, 2001; 16(4): 241 - 252. [Abstract] [PDF]
|
|
|
|
|
|
L. M. Vaina, A. Cowey, R. T. Eskew Jr, M. LeMay, and T. Kemper Regional cerebral correlates of global motion perception: Evidence from unilateral cerebral brain damage Brain, February 1, 2001; 124(2): 310 - 321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 The Neuroscientist Comments Neuroscientist, June 1, 2000; 6(3): 139 - 142. [PDF]
|
|
|
|
 |
|
 I. H. ROBERTSON Compensations for brain deficits: "Every cloud..." The British Journal of Psychiatry, May 1, 2000; 176(5): 412 - 413. [Full Text] [PDF]
|
|
|
|
 |
|
 RH Activation Correlates with Comprehension Improvement in Aphasia Journal Watch Neurology, January 1, 2000; 2000(101): 6 - 6. [Full Text]
|
|
|
|
|
|
B. B. Johansson Brain Plasticity and Stroke Rehabilitation : The Willis Lecture Stroke, January 1, 2000; 31(1): 223 - 230. [Abstract] [Full Text] [PDF]
|
|