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Brain, Vol. 123, No. 12, 2423-2431, December 2000
© 2000 Oxford University Press

Brain iron deposition in Parkinson's disease imaged using the PRIME magnetic resonance sequence

Jacqueline M. Graham, Martyn N. J. Paley, Richard A. Grünewald1, Nigel Hoggard and Paul D. Griffiths

Academic Department of Radiology and 1 Section of Clinical Neurology, University of Sheffield, Sheffield, UK

Correspondence to: Dr R. A. Grünewald, Section of Clinical Neurology, N Floor, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK E-mail: ra.grunewald{at}sheffield.ac.uk

Iron content of the basal ganglia was investigated in 25 patients with idiopathic Parkinson's disease and 14 matched healthy control subjects using a partially refocused interleaved multiple echo sequence on a 1.5 Tesla MRI system. R2* (1/T2*) and R2' (1/T2') relaxation rates were higher in the substantia nigra of patients with Parkinson's disease, which indicates that iron content is elevated in this region. R2' was lower in the putamen, indicating reduced iron levels; reduction in this region was positively correlated with disease duration. Iron-related oxidative stress may contribute to the neurodegeneration of Parkinson's disease, which may lead to alterations in the iron levels of the striatum. We describe a simple, non-invasive technique for measuring iron content.


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