Brain, Vol. 123, No. 5, 1051-1061,
May 2000
© 2000 Oxford University Press
The cerebellum contributes to higher functions during development
Evidence from a series of children surgically treated for posterior fossa tumours
1 Developmental Neurology Division and 2 Stereotactic and Functional Neurosurgery Unit, Carlo Besta National Neurological Institute, Milan, Italy
Correspondence to:
Daria Riva, MD, Developmental Neurology Division, Istituto Nazionale Neurologico C. Besta, via Celoria 11, 20133 Milano, Italy E-mail: driva{at}istituto-besta.it
We present data on the intellectual, language and executive functions of 26 children who had undergone surgery for the removal of cerebellar hemisphere or vermal tumours. The children with right cerebellar tumours presented with disturbances of auditory sequential memory and language processing, whereas those with left cerebellar tumours showed deficits on tests of spatial and visual sequential memory. The vermal lesions led to two profiles: (i) post-surgical mutism, which evolved into speech disorders or language disturbances similar to agrammatism; and (ii) behavioural disturbances ranging from irritability to behaviours reminiscent of autism. These data are consistent with the recently acknowledged role of the cerebellum as a modulator of mental and social functions, and suggest that this role is operative early in childhood.
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|
|
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