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Brain, Vol. 123, No. 6, 1073-1074, June 2000
© 2000 Oxford University Press

Editorial

P selectin, pioneer cells and the path to inflammation

William F. Hickey

The Hampers Professor and Chairman, Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire, USA

In this issue of Brain, the report by Carrithers et al. provides the first answer to a question that has long been of interest in neuroimmunology: What adhesion molecules do activated T-lymphocytes utilize to penetrate a normal, non-inflamed endothelium (Carrithers et al., 2000Go)? Their study gives some interesting insights into the earliest phases of the process of central nervous system (CNS) inflammation. It appears that P selectin, either expressed constitutively at very low levels or rapidly induced by activated T cells, on . . . [Full Text of this Article]

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