Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (143)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Jahanshahi, M.
Right arrow Articles by Limousin-Dowsey, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jahanshahi, M.
Right arrow Articles by Limousin-Dowsey, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Brain, Vol. 123, No. 6, 1142-1154, June 2000
© 2000 Oxford University Press

The impact of deep brain stimulation on executive function in Parkinson's disease

M. Jahanshahi1,2, C. M. A. Ardouin3, R. G. Brown2, J. C. Rothwell2, J. Obeso5, A. Albanese6, M. C. Rodriguez-Oroz5, E. Moro4, A. L. Benabid3, P. Pollak3 and P. Limousin-Dowsey2

1 Department of Clinical Neurology, Institute of Neurology and 2 MRC Human Movement and Balance Unit, The National Hospital for Neurology and Neurosurgery, London, 3 Neuroscience Department, Grenoble France, 4 Functional Neurology and Neurosurgery Center, Clinica Quiron, San Sebastian and 5 Department of Neurology and Neurosurgery, Division of Neuroscience, Clinica Universitaria and Medical School, University of Navarra, Pamplona, Spain and 6 Universita Cattolica, Instituto di Neurologia, Rome, Italy

Correspondence to: Dr M. Jahanshahi, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK E-mail: m.jahanshahi{at}ion.ucl.ac.uk

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or the internal segment of the globus pallidus (GPi) improves Parkinson's disease and increases frontal blood flow. We assessed the effects of bilateral DBS on executive function in Parkinson's disease patients, seven with electrodes implanted in the STN and six in the GPi. Patients were assessed off medication with stimulators off, on and off again. The groups showed differential change with stimulation on the Reitan Trail-Making test (TMT B) (STN more improved) and on some measures of random number generation and Wisconsin Card Sorting (STN improved, GPi worse with stimulation). Across the groups, stimulation speeded up responding (Stroop control trial, TMT A) and improved performance on paced serial addition and missing digit tests. Conversely, conditional associative learning became more errorful with stimulation across the two groups. In general, change in performance with stimulation was significant for the STN but not the GPi group. These results support two opposite predictions. In support of current models of Parkinson's disease, `releasing the brake' on frontal function with DBS improved aspects of executive function. Conversely, disruption of basal ganglia outflow during DBS impaired performance on tests requiring changing behaviour in novel contexts as predicted by Marsden and Obeso in 1994


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BrainHome page
E. Y. Uc, M. Rizzo, S. W. Anderson, J. D. Sparks, R. L. Rodnitzky, and J. D. Dawson
Impaired navigation in drivers with Parkinson's disease
Brain, September 1, 2007; 130(9): 2433 - 2440.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. E. Castner, H. J. Chenery, D. A. Copland, T. J. Coyne, F. Sinclair, and P. A. Silburn
Semantic and affective priming as a function of stimulation of the subthalamic nucleus in Parkinson's disease
Brain, May 1, 2007; 130(5): 1395 - 1407.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
P. -P. Derost, L. Ouchchane, D. Morand, M. Ulla, P. -M. Llorca, M. Barget, B. Debilly, J. -J. Lemaire, and F. Durif
Is DBS-STN appropriate to treat severe Parkinson disease in an elderly population?
Neurology, April 24, 2007; 68(17): 1345 - 1355.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
M F Contarino, A Daniele, A H Sibilia, L M A Romito, A R Bentivoglio, G Gainotti, and A Albanese
Cognitive outcome 5 years after bilateral chronic stimulation of subthalamic nucleus in patients with Parkinson's disease
J. Neurol. Neurosurg. Psychiatry, March 1, 2007; 78(3): 248 - 252.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Weinberger, N. Mahant, W. D. Hutchison, A. M. Lozano, E. Moro, M. Hodaie, A. E. Lang, and J. O. Dostrovsky
Beta Oscillatory Activity in the Subthalamic Nucleus and Its Relation to Dopaminergic Response in Parkinson's Disease
J Neurophysiol, December 1, 2006; 96(6): 3248 - 3256.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
H.M.M. Smeding, J. D. Speelman, M. Koning-Haanstra, P. R. Schuurman, P. Nijssen, T. van Laar, and B. Schmand
Neuropsychological effects of bilateral STN stimulation in Parkinson disease: A controlled study
Neurology, June 27, 2006; 66(12): 1830 - 1836.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
B. Pillon, C. Ardouin, K. Dujardin, P. Vittini, A. Pelissolo, O. Cottencin, L. Vercueil, J. -L. Houeto, P. Krystkowiak, Y. Agid, et al.
Preservation of cognitive function in dystonia treated by pallidal stimulation
Neurology, May 23, 2006; 66(10): 1556 - 1558.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
S. T. Grafton, R. S. Turner, M. Desmurget, R. Bakay, M. Delong, J. Vitek, and M. Crutcher
Normalizing motor-related brain activity: Subthalamic nucleus stimulation in Parkinson disease
Neurology, April 25, 2006; 66(8): 1192 - 1199.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
V Fraix, J-L Houeto, C Lagrange, C Le Pen, P Krystkowiak, D Guehl, C Ardouin, M-L Welter, F Maurel, L Defebvre, et al.
Clinical and economic results of bilateral subthalamic nucleus stimulation in Parkinson's disease
J. Neurol. Neurosurg. Psychiatry, April 1, 2006; 77(4): 443 - 449.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
W. P. M. van den Wildenberg, G. J. M. van Boxtel, M. W. van der Molen, D. A. Bosch, J. D. Speelman, and C. H. M. Brunia
Stimulation of the subthalamic region facilitates the selection and inhibition of motor responses in Parkinson's disease.
J. Cogn. Neurosci., April 1, 2006; 18(4): 626 - 636.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
E. Y. Uc, M. Rizzo, S. W. Anderson, S. Qian, R. L. Rodnitzky, and J. D. Dawson
Visual dysfunction in Parkinson disease without dementia
Neurology, December 27, 2005; 65(12): 1907 - 1913.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
T D Halbig, D Gruber, U A Kopp, G-H Schneider, T Trottenberg, and A Kupsch
Pallidal stimulation in dystonia: effects on cognition, mood, and quality of life
J. Neurol. Neurosurg. Psychiatry, December 1, 2005; 76(12): 1713 - 1716.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
M. Pessiglione, V. Czernecki, B. Pillon, B. Dubois, M. Schupbach, Y. Agid, and L. Tremblay
An Effect of Dopamine Depletion on Decision-making: The Temporal Coupling of Deliberation and Execution
J. Cogn. Neurosci., December 1, 2005; 17(12): 1886 - 1896.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
V Czernecki, B Pillon, J L Houeto, M L Welter, V Mesnage, Y Agid, and B Dubois
Does bilateral stimulation of the subthalamic nucleus aggravate apathy in Parkinson's disease?
J. Neurol. Neurosurg. Psychiatry, June 1, 2005; 76(6): 775 - 779.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
A Funkiewiez, C Ardouin, E Caputo, P Krack, V Fraix, H Klinger, S Chabardes, K Foote, A-L Benabid, and P Pollak
Long term effects of bilateral subthalamic nucleus stimulation on cognitive function, mood, and behaviour in Parkinson's disease
J. Neurol. Neurosurg. Psychiatry, June 1, 2004; 75(6): 834 - 839.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
K. Witt, U. Pulkowski, J. Herzog, D. Lorenz, W. Hamel, G. Deuschl, and P. Krack
Deep Brain Stimulation of the Subthalamic Nucleus Improves Cognitive Flexibility but Impairs Response Inhibition in Parkinson Disease
Arch Neurol, May 1, 2004; 61(5): 697 - 700.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
T. Hershey, F. J. Revilla, A. Wernle, P. S. Gibson, J. L. Dowling, and J. S. Perlmutter
Stimulation of STN impairs aspects of cognitive control in PD
Neurology, April 13, 2004; 62(7): 1110 - 1114.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
U Schroeder, A Kuehler, A Hennenlotter, B Haslinger, V M Tronnier, M Krause, R Pfister, R Sprengelmeyer, K W Lange, and A O Ceballos-Baumann
Facial expression recognition and subthalamic nucleus stimulation
J. Neurol. Neurosurg. Psychiatry, April 1, 2004; 75(4): 648 - 650.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
P. Krack, A. Batir, N. Van Blercom, S. Chabardes, V. Fraix, C. Ardouin, A. Koudsie, P. D. Limousin, A. Benazzouz, J. F. LeBas, et al.
Five-Year Follow-up of Bilateral Stimulation of the Subthalamic Nucleus in Advanced Parkinson's Disease
N. Engl. J. Med., November 13, 2003; 349(20): 1925 - 1934.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
B-M Whelan, B E Murdoch, D G Theodoros, B Hall, and P Silburn
Defining a role for the subthalamic nucleus within operative theoretical models of subcortical participation in language
J. Neurol. Neurosurg. Psychiatry, November 1, 2003; 74(11): 1543 - 1550.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
T. Hershey, F.J. Revilla, A.R. Wernle, L. McGee-Minnich, J.V. Antenor, T.O. Videen, J.L. Dowling, J.W. Mink, and J.S. Perlmutter
Cortical and subcortical blood flow effects of subthalamic nucleus stimulation in PD
Neurology, September 23, 2003; 61(6): 816 - 821.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Chudasama, C. Baunez, and T. W. Robbins
Functional Disconnection of the Medial Prefrontal Cortex and Subthalamic Nucleus in Attentional Performance: Evidence for Corticosubthalamic Interaction
J. Neurosci., July 2, 2003; 23(13): 5477 - 5485.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
C. Maurer, T. Mergner, J. Xie, M. Faist, P. Pollak, and C. H. Lucking
Effect of chronic bilateral subthalamic nucleus (STN) stimulation on postural control in Parkinson's disease
Brain, May 1, 2003; 126(5): 1146 - 1163.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
F. Schneider, U. Habel, J. Volkmann, S. Regel, J. Kornischka, V. Sturm, and H.-J. Freund
Deep Brain Stimulation of the Subthalamic Nucleus Enhances Emotional Processing in Parkinson Disease
Arch Gen Psychiatry, March 1, 2003; 60(3): 296 - 302.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
A Daniele, A Albanese, M F Contarino, P Zinzi, A Barbier, F Gasparini, L M A Romito, A R Bentivoglio, and M Scerrati
Cognitive and behavioural effects of chronic stimulation of the subthalamic nucleus in patients with Parkinson's disease
J. Neurol. Neurosurg. Psychiatry, February 1, 2003; 74(2): 175 - 182.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
P.R. Schuurman, J. Bruins, M.P. Merkus, D.A. Bosch, and J.D. Speelman
A comparison of neuropsychological effects of thalamotomy and thalamic stimulation
Neurology, October 22, 2002; 59(8): 1232 - 1239.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
E. Moro, R. J.A. Esselink, J. Xie, M. Hommel, A. L. Benabid, and P. Pollak
The impact on Parkinson's disease of electrical parameter settings in STN stimulation
Neurology, September 10, 2002; 59(5): 706 - 713.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
U. Schroeder, A. Kuehler, B. Haslinger, P. Erhard, W. Fogel, V. M. Tronnier, K. W. Lange, H. Boecker, and A. O. Ceballos-Baumann
Subthalamic nucleus stimulation affects striato-anterior cingulate cortex circuit in a response conflict task: a PET study
Brain, September 1, 2002; 125(9): 1995 - 2004.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
S. Sestini, A. Scotto di Luzio, F. Ammannati, M. T. R. De Cristofaro, A. Passeri, S. Martini, and A. Pupi
Changes in Regional Cerebral Blood Flow Caused by Deep-Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease
J. Nucl. Med., June 1, 2002; 43(6): 725 - 732.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
R. B. Scott, J. Harrison, C. Boulton, J. Wilson, R. Gregory, S. Parkin, P. G. Bain, C. Joint, J. Stein, and T. Z. Aziz
Global attentional-executive sequelae following surgical lesions to globus pallidus interna
Brain, March 1, 2002; 125(3): 562 - 574.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. C. Rodriguez-Oroz, M. Rodriguez, J. Guridi, K. Mewes, V. Chockkman, J. Vitek, M. R. DeLong, and J. A. Obeso
The subthalamic nucleus in Parkinson's disease: somatotopic organization and physiological characteristics
Brain, September 1, 2001; 124(9): 1777 - 1790.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.