| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Brain, Vol. 124, No. 1, 2-4,
January 2001
© 2001 Oxford University Press
Editorial |
Mapping the ischaemic penumbra with PET: a new approach
Professor of Stroke Medicine, University of Cambridge Neurology Unit, Addenbrooke's Hospital, Cambridge, UK
After decades of nihilism, recent evidence indicates that neurological outcome after acute stroke can be improved through three types of measures (Brott and Bogousslavsky, 2000
): (i) restoring perfusion in the ischaemic tissue with the thrombolytic agent recombinant tissue plasminogen activator (rt-PA) given intravenously within 3 h of clinical onset; (ii) preventing secondary deleterious events such as hyperglycaemia, pyrexia, hypoxia, systemic hypotension, stroke recurrence and pulmonary embolism, best achieved in specialized stroke units; and (iii) providing appropriate rehabilitation. The reperfusion strategy is based on experimental evidence in the nonhuman primate with middle cerebral artery (MCA) occlusion that, surrounding the profoundly ischaemic core of already irreversible damage, there exists an area of brain tissue (the `penumbra') which, though severely ischaemic and functionally silent, can still escape infarction if perfusion is restored before a certain time has elapsed (Lassen, 1990); the penumbra has been documented in man
References
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Trivedi and J. P. Coles Blood Pressure Management in Acute Head Injury J Intensive Care Med, March 1, 2009; 24(2): 96 - 107. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Takasawa, R. R. Moustafa, and J.-C. Baron Applications of Nitroimidazole In Vivo Hypoxia Imaging in Ischemic Stroke Stroke, May 1, 2008; 39(5): 1629 - 1637. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. V. Guadagno, E. A. Warburton, P. S. Jones, D. J. Day, F. I. Aigbirhio, T. D. Fryer, S. Harding, C. J. Price, H. A. Green, O. Barret, et al. How affected is oxygen metabolism in DWI lesions?: A combined acute stroke PET-MR study. Neurology, September 12, 2006; 67(5): 824 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Markus, D. C. Reutens, S. Kazui, S. Read, P. Wright, D. C. Pearce, H. J. Tochon-Danguy, J. I. Sachinidis, and G. A. Donnan Hypoxic tissue in ischaemic stroke: persistence and clinical consequences of spontaneous survival Brain, June 1, 2004; 127(6): 1427 - 1436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Saita, M. Chen, N. J. Spratt, M. J. Porritt, G. T. Liberatore, S. J. Read, C. R. Levi, G. A. Donnan, U. Ackermann, H. J. Tochon-Danguy, et al. Imaging the Ischemic Penumbra with 18F-Fluoromisonidazole in a Rat Model of Ischemic Stroke Stroke, April 1, 2004; 35(4): 975 - 980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. H. Danton and W. D. Dietrich The Search for Neuroprotective Strategies in Stroke AJNR Am. J. Neuroradiol., February 1, 2004; 25(2): 181 - 194. [Full Text] [PDF]
|
|
|
|
|
|
D. J. Gladstone, S. E. Black, and A. M. Hakim Toward Wisdom From Failure: Lessons From Neuroprotective Stroke Trials and New Therapeutic Directions Stroke, August 1, 2002; 33(8): 2123 - 2136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. U. Harrer and C. Klotzsch Second Harmonic Imaging of the Human Brain: The Practicability of Coronal Insonation Planes and Alternative Perfusion Parameters Stroke, June 1, 2002; 33(6): 1530 - 1535. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Plum Neuroprotection in Acute Ischemic Stroke JAMA, April 4, 2001; 285(13): 1760 - 1761. [Full Text] [PDF]
|
|