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Brain, Vol. 124, No. 10, 1897-1899, October 2001
© 2001 Oxford University Press

Editorial

Gene microarrays and experimental demyelinating disease: a tool to enhance serendipity

Lawrence Steinman

Department of Neurological Sciences, Beckman Center for Molecular Medicine, Stanford University, USA

A few years ago a new technology for monitoring gene transcription arrived and profiling thousands of gene transcripts simultaneously from small amounts of tissue became possible. In this issue of Brain, Ibrahim and colleagues applied this technology to monitor gene transcription in a model of multiple sclerosis. They found that 213 genes were differentially regulated, including increased expression of immune-related molecules and genes involved in the movement of cells such as metalloproteases and adhesion molecules (Ibrahim et al., 2001Go).

Several different types of microarrays have been developed based on cDNA clones, PCR products or oligonucleotides immobilized on a solid support. The Affymetrix Genechip (Affymetrix, Santa Clara, Calif., USA) . . . [Full Text of this Article]

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