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Brain, Vol. 124, No. 11, 2147-2161, November 2001
© 2001 Oxford University Press

Towards the reconstruction of central nervous system white matter using neural precursor cells

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Masato Mitome1,*, Hoi Pang Low1, Anthony van den Pol3, John J. Nunnari2, Merrill K. Wolf1,2, Susan Billings-Gagliardi1,2 and William J. Schwartz1

1 Departments of Neurology, and 2 Cell Biology, University of Massachusetts Medical School, Worcester and 3 Department of Neurosurgery, Yale University School of Medicine, New Haven, USA

Correspondence to: William J. Schwartz, Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA E-mail: william.schwartz{at}umassmed.edu

Epidermal growth factor-responsive neural precursor cells were used as donor cells for transplantation into wild-type and myelin-deficient shiverer (shi) mice. The cells engrafted robustly within the CNS following intracerebroventricular and cisternal transplantation in neonatal mice. The cells adopted glial phenotypes, and some functioned as oligodendrocytes, producing myelin basic protein and morphologically normal internodal myelin sheaths. When individual shi mice received two transplants (on post-natal days 1 and 3), donor-derived cells disseminated widely and expressed myelin basic protein in central white matter tracts throughout the brain.


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