Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (14)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Sundstrom, L. E.
Right arrow Articles by Rougier, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sundstrom, L. E.
Right arrow Articles by Rougier, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Brain, Vol. 124, No. 4, 688-697, April 2001
© 2001 Oxford University Press

Somatostatin- and neuropeptide Y-synthesizing neurones in the fascia dentata of humans with temporal lobe epilepsy

L. E. Sundstrom1, C. Brana1,2, M. Gatherer1, J. Mepham1 and A. Rougier2

1 Centre for Neurosciences, Southampton University, Southampton General Hospital, UK and 2 Laboratoire d'Epileptologie Expérimentale et Clinique, Université Victor Ségalen, Bordeaux, France

Correspondence to: Dr L. E. Sundstrom, Centre for Neurosciences, Mail Point 806, Southampton University, Level F, South Academic Block, Southampton General Hospital, Tremona Road, Southampton S016 6YD, UK E-mail: les{at}soton.ac.uk

We used in situ hybridization techniques to study the distribution of neurones synthesizing somatostatin mRNA and neuropeptide Y mRNA in the hilar region of the hippocampal formation of patients with temporal lobe epilepsy. In the dentate gyrus, somatostatin mRNA- and neuropeptide Y mRNA-synthesizing neurones were found to be exclusively located within the hilar region. Unlike animal models, no ectopic expression of either peptide was found in principal cells. The numbers of hilar interneurones expressing somatostatin mRNA and neuropeptide Y mRNA were compared with the degree of hilar cell loss determined by immunohistochemistry against neuronal nuclear antigen. The numbers of somatostatin and neuropeptide Y mRNA-synthesizing neurones varied considerably between patients, but both were found to be highly correlated to the total number of neuronal nuclear antigen-immunoreactive hilar neurones. These results suggest that loss of somatostatin and neuropeptide Y interneurones occurs in proportion to overall hilar cell loss, and therefore the hypothesis of a selective loss of these interneurones in temporal lobe epilepsy seems unlikely.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
W. Zhang, R. Yamawaki, X. Wen, J. Uhl, J. Diaz, D. A. Prince, and P. S. Buckmaster
Surviving Hilar Somatostatin Interneurons Enlarge, Sprout Axons, and Form New Synapses with Granule Cells in a Mouse Model of Temporal Lobe Epilepsy
J. Neurosci., November 11, 2009; 29(45): 14247 - 14256.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. Thom, L. Martinian, C. Catarino, M. Yogarajah, M. J. Koepp, L. Caboclo, and S. M. Sisodiya
Bilateral reorganization of the dentate gyrus in hippocampal sclerosis: A postmortem study
Neurology, September 29, 2009; 73(13): 1033 - 1040.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R.-Z. Zhan and J. V. Nadler
Enhanced Tonic GABA Current in Normotopic and Hilar Ectopic Dentate Granule Cells After Pilocarpine-Induced Status Epilepticus
J Neurophysiol, August 1, 2009; 102(2): 670 - 681.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Richichi, E.-J. D. Lin, D. Stefanin, D. Colella, T. Ravizza, G. Grignaschi, P. Veglianese, G. Sperk, M. J. During, and A. Vezzani
Anticonvulsant and Antiepileptogenic Effects Mediated by Adeno-Associated Virus Vector Neuropeptide Y Expression in the Rat Hippocampus
J. Neurosci., March 24, 2004; 24(12): 3051 - 3059.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. M. Powell, D. B. Campbell, G. D. Stanwood, C. Davis, J. L. Noebels, and P. Levitt
Genetic Disruption of Cortical Interneuron Development Causes Region- and GABA Cell Type-Specific Deficits, Epilepsy, and Behavioral Dysfunction
J. Neurosci., January 15, 2003; 23(2): 622 - 631.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.