Brain, Vol. 124, No. 8, 1555-1565,
August 2001
© 2001 Oxford University Press
Central benzodiazepine receptors in malformations of cortical development
A quantitative study
1 MRC Cyclotron Unit, Clinical Sciences Centre, Hammersmith Hospital and 2 National Society for Epilepsy, Institute of Neurology, London, UK
Correspondence to:
Professor John S. Duncan, National Society for Epilepsy and Institute of Neurology, 33 Queen Square, London WC1N 3BG, UK E-mail: j.duncan{at}ion.ucl.ac.uk
We calculated [11C]flumazenil volume of distribution ([11C]FMZ-Vd) after correction for partial volume effect in 10 patients with malformations of cortical development (MCDs) and partial seizures, to quantify the GABAA–central benzodiazepine receptor complex. Abnormal grey matter and adjacent or overlying cortex were outlined individually and added to an individualized anatomical template for correction for partial volume effect. Nine of 10 patients showed single or multiple increases or decreases in [11C]FMZ-Vd in or around MCDs. Two of three patients with band heterotopia showed multiple increases in the overlying cortex. In three of four patients with subependymal nodular heterotopia, nodules had lower [11C]FMZ-Vd than the overlying cortex, which was normal. Decreases in [11C]FMZ-Vd were found in two of three clefts and one of six adjacent regions in one schizencephalic patient; another had normal [11C]FMZ-Vd in the thickened cortex itself but increases in all adjacent regions. Binding was reduced within focal cortical dysplasia but increased in adjacent cortex. [11C]FMZ-Vd was normal within one patient's polymicrogyric cortex but increased in one of six adjacent volumes of interest. The localization of abnormalities correlated with EEG and clinical data in cortical MCDs. Flumazenil binding was decreased in some MCDs with increased grey matter volume and increased in some adjacent or overlying areas of normal-appearing cortex, suggesting functional abnormalities beyond MRI- detectable structural changes.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Croquelois, F. Giuliani, C. Savary, M. Kielar, C. Amiot, F. Schenk, and E. Welker Characterization of the HeCo Mutant Mouse: A New Model of Subcortical Band Heterotopia Associated with Seizures and Behavioral Deficits Cereb Cortex, June 18, 2008; (2008) bhn106v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kato, E. Shimosegawa, N. Oku, K. Kitagawa, H. Kishima, Y. Saitoh, A. Kato, T. Yoshimine, and J. Hatazawa MRI-Based Correction for Partial-Volume Effect Improves Detectability of Intractable Epileptogenic Foci on 123I-Iomazenil Brain SPECT Images J. Nucl. Med., March 1, 2008; 49(3): 383 - 389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Merlet, K. Ostrowsky, N. Costes, P. Ryvlin, J. Isnard, I. Faillenot, F. Lavenne, D. Dufournel, D. Le Bars, and F. Mauguiere 5-HT1A receptor binding and intracerebral activity in temporal lobe epilepsy: an [18F]MPPF-PET study Brain, April 1, 2004; 127(4): 900 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hammers, M. J. Koepp, M. P. Richardson, R. Hurlemann, D. J. Brooks, and J. S. Duncan Grey and white matter flumazenil binding in neocortical epilepsy with normal MRI. A PET study of 44 patients Brain, June 1, 2003; 126(6): 1300 - 1318. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J. Rugg-Gunn, S. H. Eriksson, P. A. Boulby, M. R. Symms, G. J. Barker, and J. S. Duncan Magnetization transfer imaging in focal epilepsy Neurology, May 27, 2003; 60(10): 1638 - 1645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Juhasz, D.C. Chugani, O. Muzik, A. Shah, E. Asano, T.J. Mangner, P.K. Chakraborty, S. Sood, and H.T. Chugani Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy Neurology, March 25, 2003; 60(6): 960 - 968. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P Richardson Epilepsy and surgical mapping Br. Med. Bull., March 1, 2003; 65(1): 179 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Frouin, C. Comtat, A. Reilhac, and M.-C. Gregoire Correction of Partial-Volume Effect for PET Striatal Imaging: Fast Implementation and Study of Robustness J. Nucl. Med., December 1, 2002; 43(12): 1715 - 1726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hammers, M. J. Koepp, R. Hurlemann, M. Thom, M. P. Richardson, D. J. Brooks, and J. S. Duncan Abnormalities of grey and white matter [11C]flumazenil binding in temporal lobe epilepsy with normal MRI Brain, October 1, 2002; 125(10): 2257 - 2271. [Abstract] [Full Text] [PDF]
|
|