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Brain, Vol. 125, No. 4, 693-694, April 2002
© 2002 Guarantors of Brain

Editorial

Toxicity of CSF in motor neurone disease: a potential route to neuroprotection

Pamela J. Shaw1

1 Academic Neurology Unit, University of Sheffield, UK

The paper by Tikka and colleagues in this issue of Brain reports that CSF from patients with motor neurone disease (MND) is toxic to cultured spinal cord neurones and that the tetracycline antibiotic minocycline exerts a significant neuroprotective effect against this toxicity (Tikka et al., 2002Go).

There is a tendency in MND for the disease to start focally, for example with weakness of one hand, unilateral foot drop or dysarthria. As judged by clinical signs of progression, the disease typically tends to spread to contiguous groups of motor neurones. There has been great interest in the possible diffusible factors which may contribute to this propagation of neuronal injury between adjacent groups of motor neurones. Potential candidates include nitric oxide; free radical species or toxic chemicals resulting from . . . [Full Text of this Article]

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