Brain, Vol. 125, No. 6, 1175-1176,
June 2002
© 2002 Guarantors of Brain
Editorial |
Neural rhythms in Parkinson’s disease
1 St Mary’s Hospital and National Hospital for Neurology and Neurosurgery, London, UK
Neurologists should take brain rhythms seriously. Classical neurophysiology has focused on the encoding of information through changes in the firing rate of neurones, the salience of a stimulus or initiation of a motor response being accompanied by increases or decreases in neuronal activity. Yet when networks of neurones interact the result is often rhythmic activity within defined frequency ranges that can engage in temporal synchronization and de-synchronization. Neurologists are predisposed to consider all rhythmicity as pathological. After all, in our working lives we diagnose essential tremor and the tremor of Parkinson’s disease and many of our concepts of diseases such as epilepsy are bound up with ideas of widespread rhythmic synchronization of neural elements resulting in loss of consciousness and violent involuntary movement.
Over recent years a more sophisticated appreciation of neural rhythmicity and temporal synchronization has emerged. Neurophysiologists can now record simultaneously from
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