Brain, Vol. 125, No. 9, 1951-1959,
September 2002
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Magnetic resonance imaging findings within 5 days of status epilepticus in childhood
1 Great Ormond Street Hospital for Children NHS Trust, and 2 Neurosciences Unit and 3 Radiology and Physics Unit, Institute of Child Health, University College London, London, UK
Correspondence to: Rod C. Scott, The Wolfson Centre, Mecklenburgh Square, London WC1N 2AP, UK E-mail: rscott{at}ich.ucl.ac.uk
The nature of the relationships between status epilepticus, acute hippocampal injury, mesial temporal sclerosis (MTS) and temporal lobe epilepsy remains unclear. The aim of this study was to investigate whether generalized status epilepticus is associated with brain abnormalities, especially in the mesial temporal lobe, within 5 days of the acute event. Such changes may be the first part of a causative pathophysiological sequence relating status epilepticus and MTS. Thirty-five children with a history of status epilepticus, including 21 with a history of prolonged febrile convulsion (PFC), underwent qualitative and quantitative MRI investigations within 5 days of the acute episode. Quantitative assessments of the hippocampus included T2 relaxometry and hippocampal volumetry. Hippocampal volumes were large in patients with PFC when compared with controls. In addition, T2 relaxation time was elevated in patients with PFC compared with control subjects during the first 2 days of the acute event. No difference was observed in patients examined 3–5 days after the event. Patients with afebrile status epilepticus had a variety of imaging abnormalities including elevated hippocampal T2 values, but no evidence of hippocampal enlargement. PFC is associated with hippocampal abnormalities, consistent with hippocampal oedema, whilst non-febrile status epilepticus is not. A systematic longitudinal study is required to characterize the evolution of these abnormalities and to determine whether any patient develops MTS.
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