Brain, Vol. 125, No. 9, 2089-2099,
September 2002
© 2002 Guarantors of Brain
Altered sensorimotor integration in Parkinson’s disease
0 Human Motor Control Laboratory, Department of Sport and Exercise Science, University of Auckland, New Zealand
Correspondence to: Gwyn N. Lewis, Department of Sport and Exercise Science, University of Auckland, Private Bag 92019, Auckland, New Zealand E-mail: gn.lewis{at}auckland.ac.nz
Transcranial magnetic stimulation (TMS) was used to investigate sensorimotor integration in the upper limb of 10 patients with Parkinson’s disease and 10 age-matched controls. Non-conditioned and subthreshold conditioned (2 ms interstimulus interval) responses were recorded in the flexor and extensor carpi radialis muscles (FCR and ECR) of the more impaired (non-dominant) limb. Stimuli were delivered while the wrist joint was positioned statically at various joint angles as well as during different phases of passive movement of the wrist joint (90° amplitude, 0.2 Hz). The FCR and ECR muscles remained relaxed during all stimulation. In both groups, responses in the static condition were larger when the target muscle was in a shortened position. Responses were also facilitated in the muscle shortening phases of passive movement. In both static and dynamic conditions, the extent of modulations in response amplitude was significantly reduced in the patient group. The level of intracortical inhibition (ICI) was also significantly less in the Parkinson’s disease patients in static conditions. During passive movement, control subjects demonstrated a clear reduction in ICI compared with the static trials; however, the level of ICI was unchanged in the Parkinson’s disease group in the dynamic condition. The results suggest an abnormal influence of afference on corticomotor excitability in Parkinson’s disease. This may be related to abnormal sensory input, a defective integrative unit or an inappropriate motor response.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Nolano, V. Provitera, A. Estraneo, M. M. Selim, G. Caporaso, A. Stancanelli, A. M. Saltalamacchia, B. Lanzillo, and L. Santoro Sensory deficit in Parkinson's disease: evidence of a cutaneous denervation Brain, July 1, 2008; 131(7): 1903 - 1911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Halliday, V. Macdonald, and J. M. Henderson A comparison of degeneration in motor thalamus and cortex between progressive supranuclear palsy and Parkinson's disease Brain, October 1, 2005; 128(10): 2272 - 2280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Michell, S. J. G. Lewis, T. Foltynie, and R. A. Barker Biomarkers and Parkinson's disease Brain, August 1, 2004; 127(8): 1693 - 1705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Djaldetti, A. Shifrin, Z. Rogowski, E. Sprecher, E. Melamed, and D. Yarnitsky Quantitative measurement of pain sensation in patients with Parkinson disease Neurology, June 22, 2004; 62(12): 2171 - 2175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sailer, G. F. Molnar, G. Paradiso, C. A. Gunraj, A. E. Lang, and R. Chen Short and long latency afferent inhibition in Parkinson's disease Brain, August 1, 2003; 126(8): 1883 - 1894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Loddenkemper, C. Kellinghaus, H. O. Luders, J. Dauper, C. Schrader, and J.D. Rollnik Effects of subthalamic nucleus (STN) stimulation on motor cortex excitability Neurology, March 11, 2003; 60(5): 885 - 886. [Full Text] [PDF]
|
|