Brain Advance Access originally published online on August 5, 2003
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Brain, Vol. 126, No. 11, 2528-2536,
November 2003
© 2003 Guarantors of Brain
doi: 10.1093/brain/awg261
Primary progressive multiple sclerosis: a 5-year clinical and MR study
1 Institute of Neurology, University College, London and 2 The National Hospital for Neurology and Neurosurgery, London, UK
Correspondence to: Professor Alan J. Thompson, Institute of Neurology, Uuniversity College, London, Queen Square, London WC1N 3BG, UK E-mail: a.thompson{at}ion.ucl.ac.uk
Longitudinal imaging studies of primary progressive multiple sclerosis (PPMS) have shown significant changes in MR measures over 1 to 2 years. Correlation with clinical change over the same period has not been evident; we investigated the possibility that this is because the period of observation was insufficient for these associations to become apparent. Forty-one patients with PPMS were followed prospectively for 5 years. Patients had clinical [Expanded Disability Status Scale (EDSS) and Multiple Sclerosis Functional Composite Measure (MSFC)] and MRI assessment (brain and spinal cord) at baseline, 1, 2 and 5 years. At 5 years, significant deterioration was seen in all clinical and MRI measures (P < 0.01, P < 0.001 respectively). Associations were seen between increase in EDSS score and decrease in cord area (r = 0.31, P < 0.05) and between increase in MSFC and both rate of ventricular enlargement (r = 0.31, P < 0.05) and increase in T2 load (r = 0.31, P < 0.05). The rates of change of MR measures were not associated with age or disease duration and were more consistent within than between patients. Longer duration of follow-up demonstrates modest associations between change in clinical and MR measures and provides new insights into the pattern of change within and between individuals with PPMS.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. J. Kragt, A. J. Thompson, X. Montalban, M. Tintore, J. Rio, C. H. Polman, and B.M.J. Uitdehaag Responsiveness and predictive value of EDSS and MSFC in primary progressive MS Neurology, March 25, 2008; 70(13_Part_2): 1084 - 1091. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Zivadinov, A.C. Banas, V. Yella, N. Abdelrahman, B. Weinstock-Guttman, and M.G. Dwyer Comparison of Three Different Methods for Measurement of Cervical Cord Atrophy in Multiple Sclerosis AJNR Am. J. Neuroradiol., February 1, 2008; 29(2): 319 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z Khaleeli, J Sastre-Garriga, O Ciccarelli, D H Miller, and A J Thompson Magnetisation transfer ratio in the normal appearing white matter predicts progression of disability over 1 year in early primary progressive multiple sclerosis J. Neurol. Neurosurg. Psychiatry, October 1, 2007; 78(10): 1076 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Agosta, M. Absinta, M. P. Sormani, A. Ghezzi, A. Bertolotto, E. Montanari, G. Comi, and M. Filippi In vivo assessment of cervical cord damage in MS patients: a longitudinal diffusion tensor MRI study Brain, August 1, 2007; 130(8): 2211 - 2219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Khan Can clinical outcomes be used to detect neuroprotection in multiple sclerosis? Neurology, May 29, 2007; 68(22_suppl_3): S64 - S71. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rovaris, E. Judica, A. Gallo, B. Benedetti, M. P. Sormani, D. Caputo, A. Ghezzi, E. Montanari, A. Bertolotto, G. Mancardi, et al. Grey matter damage predicts the evolution of primary progressive multiple sclerosis at 5 years Brain, October 1, 2006; 129(10): 2628 - 2634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Confavreux and S. Vukusic Natural history of multiple sclerosis: a unifying concept Brain, March 1, 2006; 129(3): 606 - 616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Camp, V. L. Stevenson, A. J. Thompson, G. T. Ingle, D. H. Miller, C. Borras, B. Brochet, V. Dousset, M. Falautano, M. Filippi, et al. A longitudinal study of cognition in primary progressive multiple sclerosis Brain, December 1, 2005; 128(12): 2891 - 2898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kutzelnigg, C. F. Lucchinetti, C. Stadelmann, W. Bruck, H. Rauschka, M. Bergmann, M. Schmidbauer, J. E. Parisi, and H. Lassmann Cortical demyelination and diffuse white matter injury in multiple sclerosis Brain, November 1, 2005; 128(11): 2705 - 2712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Agosta, B. Benedetti, M. A. Rocca, P. Valsasina, M. Rovaris, G. Comi, and M. Filippi Quantification of cervical cord pathology in primary progressive MS using diffusion tensor MRI Neurology, February 22, 2005; 64(4): 631 - 635. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F G Maggs and J Palace The pathogenesis of multiple sclerosis: is it really a primary inflammatory process? Multiple Sclerosis, June 1, 2004; 10(3): 326 - 329. [Abstract] [PDF]
|
|
|
|
|
|
A. Thompson Overview of primary progressive multiple sclerosis (PPMS): similarities and differences from other forms of MS, diagnostic criteria, pros and cons of progressive diagnosis Multiple Sclerosis, May 1, 2004; 10(3_suppl): S2 - S7. [Abstract] [PDF]
|
|