Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (34)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Van Paesschen, W.
Right arrow Articles by Maes, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Van Paesschen, W.
Right arrow Articles by Maes, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Brain, Vol. 126, No. 5, 1103-1111, May 2003
© 2003 Guarantors of Brain
doi: 10.1093/brain/awg108

SPECT perfusion changes during complex partial seizures in patients with hippocampal sclerosis

W. Van Paesschen1, P. Dupont2, G. Van Driel1, H. Van Billoen3 and A. Maes2

Departments of 1 Neurology, 2 Nuclear Medicine and 3 Radiopharmacy, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium

Correspondence to: Wim Van Paesschen, Department of Neurology, UZ Gasthuisberg, 49 Herestraat, 3000 Leuven, Belgium E-mail: wim.vanpaesschen{at}uz.kuleuven.ac.be

Cerebral perfusion changes reliably reflect changes in neuronal activity. Our aim was to obtain new insights into the pathophysiology of complex partial seizures (CPS) in patients with hippocampal sclerosis (HS) using interictal and ictal single photon emission computed tomography (SPECT). We studied 24 patients with refractory temporal lobe epilepsy (TLE) associated with HS. All had an interictal and ictal SPECT with early injection during a CPS. Images were normalized and co-registered. Using statistical parametric mapping (SPM99), brain regions with significant ictal perfusion changes were determined. To assess possible interrelationships between these regions, Pearson correlation coefficients were calculated. The temporal lobe ipsilateral to the seizure focus, the border of the ipsilateral middle frontal and precentral gyrus, both occipital lobes and two small regions in the contralateral postcentral gyrus showed ictal hyperperfusion. The frontal lobes, contralateral posterior cerebellum and ipsilateral precuneus showed hypoperfusion. Further exploratory analysis suggested an association between ipsilateral temporal lobe hyperperfusion and ipsilateral frontal lobe hypoperfusion, and an inverse association between seizure duration and hyperperfusion in the ipsilateral anterior cerebellum and contralateral postcentral gyrus. We conclude that there is a network of perfusion changes during CPS in patients with HS. Studying a particular seizure type in patients with HS with peri-ictal SPECT performed during a defined time window will allow further analysis of the cerebral network activities, and excitatory, inhibitory and gating mechanisms during seizures associated with HS.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
D. J. Englot, B. Modi, A. M. Mishra, M. DeSalvo, F. Hyder, and H. Blumenfeld
Cortical Deactivation Induced by Subcortical Network Dysfunction in Limbic Seizures
J. Neurosci., October 14, 2009; 29(41): 13006 - 13018.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
G. I. Varghese, M. J. Purcaro, J. E. Motelow, M. Enev, K. A. McNally, A. R. Levin, L. J. Hirsch, R. Tikofsky, A. L. Paige, I. G. Zubal, et al.
Clinical use of ictal SPECT in secondarily generalized tonic-clonic seizures
Brain, August 1, 2009; 132(8): 2102 - 2113.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
S. Takaya, N. Mikuni, T. Mitsueda, T. Satow, J. Taki, M. Kinoshita, S. Miyamoto, N. Hashimoto, A. Ikeda, and H. Fukuyama
Improved cerebral function in mesial temporal lobe epilepsy after subtemporal amygdalohippocampectomy
Brain, January 1, 2009; 132(1): 185 - 194.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. J. Englot, A. M. Mishra, P. K. Mansuripur, P. Herman, F. Hyder, and H. Blumenfeld
Remote Effects of Focal Hippocampal Seizures on the Rat Neocortex
J. Neurosci., September 3, 2008; 28(36): 9066 - 9081.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
J. J. Lin, N. Salamon, A. D. Lee, R. A. Dutton, J. A. Geaga, K. M. Hayashi, E. Luders, A. W. Toga, J. Engel Jr, and P. M. Thompson
Reduced Neocortical Thickness and Complexity Mapped in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis
Cereb Cortex, September 1, 2007; 17(9): 2007 - 2018.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M.T. Doelken, G. Richter, H. Stefan, A. Doerfler, A. Noemayr, T. Kuwert, O. Ganslandt, C.H. Nimsky, and T. Hammen
Multimodal Coregistration in Patients with Temporal Lobe Epilepsy--Results of Different Imaging Modalities in Lateralization of the Affected Hemisphere in MR Imaging Positive and Negative Subgroups
AJNR Am. J. Neuroradiol., March 1, 2007; 28(3): 449 - 454.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
R. E. Hogan, K. Kaiboriboon, M. E. Bertrand, V. Rao, and J. Acharya
Composite SISCOM Perfusion Patterns in Right and Left Temporal Seizures.
Arch Neurol, October 1, 2006; 63(10): 1419 - 1426.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
E. Y. Joo, S. B. Hong, H. J. Han, W. S. Tae, J. H. Kim, S. J. Han, D. W. Seo, K.-H. Lee, S.-C. Hong, M. Lee, et al.
Postoperative alteration of cerebral glucose metabolism in mesial temporal lobe epilepsy
Brain, August 1, 2005; 128(8): 1802 - 1810.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
K. Kaiboriboon, M. E. Bertrand, M. M. Osman, and R. E. Hogan
Quantitative Analysis of Cerebral Blood Flow Patterns in Mesial Temporal Lobe Epilepsy Using Composite SISCOM
J. Nucl. Med., January 1, 2005; 46(1): 38 - 43.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
G. D. Cascino, J. R. Buchhalter, J. I. Sirven, E. L. So, J. F. Drazkowski, R. S. Zimmerman, and C. Raffel
Peri-ictal SPECT and surgical treatment for intractable epilepsy related to schizencephaly
Neurology, December 28, 2004; 63(12): 2426 - 2428.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
H. Blumenfeld, M. Rivera, K. A. McNally, K. Davis, D. D. Spencer, and S. S. Spencer
Ictal neocortical slowing in temporal lobe epilepsy
Neurology, September 28, 2004; 63(6): 1015 - 1021.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
H. Blumenfeld, K. A. McNally, S. D. Vanderhill, A. L. Paige, R. Chung, K. Davis, A. D. Norden, R. Stokking, C. Studholme, E. J. Novotny Jr, et al.
Positive and Negative Network Correlations in Temporal Lobe Epilepsy
Cereb Cortex, August 1, 2004; 14(8): 892 - 902.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
H. Blumenfeld and J. Taylor
Why do Seizures Cause Loss of Consciousness?
Neuroscientist, October 1, 2003; 9(5): 301 - 310.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.