Brain Advance Access originally published online on June 23, 2003
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Brain, Vol. 126, No. 8, 1830-1837,
August 2003
© 2003 Guarantors of Brain
doi: 10.1093/brain/awg180
Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm
Center for Cognitive Neuroscience, University of Pennsylvania, Philadelphia, USA
Correspondence to: Lesley K. Fellows, Center for Cognitive Neuroscience, University of Pennsylvania, 3815 Walnut St, Philadelphia, PA 19104–6196, USA E-mail: lesleyf{at}psych.upenn.edu
How do the frontal lobes support behavioural flexibility? One key element is the ability to adjust responses when the reinforcement value of stimuli change. In monkeys, this ability—a form of affective shifting known as reversal learning—depends on orbitofrontal cortex. The present study examines the anatomical bases of reversal learning in humans. Subjects with lesions of the ventromedial prefrontal cortex were compared with a group with dorsolateral frontal lobe damage, as well as with normal controls on a simple reversal learning task. Neither form of frontal damage affected initial stimulus–reinforcement learning; ventromedial frontal damage selectively impaired reversal learning.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. G. Ghahremani, J. Monterosso, J. D. Jentsch, R. M. Bilder, and R. A. Poldrack Neural Components Underlying Behavioral Flexibility in Human Reversal Learning Cereb Cortex, November 13, 2009; (2009) bhp247v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Li, E. Xiao, D. Houser, and P. R. Montague Neural responses to sanction threats in two-party economic exchange PNAS, September 29, 2009; 106(39): 16835 - 16840. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Christakou, M. Brammer, V. Giampietro, and K. Rubia Right Ventromedial and Dorsolateral Prefrontal Cortices Mediate Adaptive Decisions under Ambiguity by Integrating Choice Utility and Outcome Evaluation J. Neurosci., September 2, 2009; 29(35): 11020 - 11028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Elliott, Z. Agnew, and J.F.W. Deakin Hedonic and Informational Functions of the Human Orbitofrontal Cortex Cereb Cortex, May 12, 2009; (2009) bhp092v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.S. Man, H.F. Clarke, and A.C. Roberts The Role of the Orbitofrontal Cortex and Medial Striatum in the Regulation of Prepotent Responses to Food Rewards Cereb Cortex, April 1, 2009; 19(4): 899 - 906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Jocham, T. A. Klein, J. Neumann, D. Y. von Cramon, M. Reuter, and M. Ullsperger Dopamine DRD2 Polymorphism Alters Reversal Learning and Associated Neural Activity J. Neurosci., March 25, 2009; 29(12): 3695 - 3704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kazama and J. Bachevalier Selective Aspiration or Neurotoxic Lesions of Orbital Frontal Areas 11 and 13 Spared Monkeys' Performance on the Object Discrimination Reversal Task J. Neurosci., March 4, 2009; 29(9): 2794 - 2804. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Ragland, R. Cools, M. Frank, D. A. Pizzagalli, A. Preston, C. Ranganath, and A. D. Wagner CNTRICS Final Task Selection: Long-Term Memory Schizophr Bull, January 1, 2009; 35(1): 197 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. H. Rudebeck, T. E. Behrens, S. W. Kennerley, M. G. Baxter, M. J. Buckley, M. E. Walton, and M. F. S. Rushworth Frontal Cortex Subregions Play Distinct Roles in Choices between Actions and Stimuli J. Neurosci., December 17, 2008; 28(51): 13775 - 13785. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. H. Rudebeck, D. M. Bannerman, and M. F. S. Rushworth The contribution of distinct subregions of the ventromedial frontal cortex to emotion, social behavior, and decision making Cogn Affect Behav Neurosci, December 1, 2008; 8(4): 485 - 497. [Abstract] [PDF]
|
|
|
|
 |
|
 T. J.R Beveridge, K. E Gill, C. A Hanlon, and L. J Porrino Parallel studies of cocaine-related neural and cognitive impairment in humans and monkeys Phil Trans R Soc B, October 12, 2008; 363(1507): 3257 - 3266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. K. Murray, F. Cheng, L. Clark, J. H. Barnett, A. D. Blackwell, P. C. Fletcher, T. W. Robbins, E. T. Bullmore, and P. B. Jones Reinforcement and Reversal Learning in First-Episode Psychosis Schizophr Bull, September 1, 2008; 34(5): 848 - 855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. van Duuren, J. Lankelma, and C. M. A. Pennartz Population Coding of Reward Magnitude in the Orbitofrontal Cortex of the Rat J. Neurosci., August 20, 2008; 28(34): 8590 - 8603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.J.R Blair The amygdala and ventromedial prefrontal cortex: functional contributions and dysfunction in psychopathy Phil Trans R Soc B, August 12, 2008; 363(1503): 2557 - 2565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. L. Reekie, K. Braesicke, M. S. Man, and A. C. Roberts Uncoupling of behavioral and autonomic responses after lesions of the primate orbitofrontal cortex PNAS, July 15, 2008; 105(28): 9787 - 9792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. E. Wilson and D. Gaffan Prefrontal-Inferotemporal Interaction Is Not Always Necessary for Reversal Learning J. Neurosci., May 21, 2008; 28(21): 5529 - 5538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. C. Finger, A. A. Marsh, D. G. Mitchell, M. E. Reid, C. Sims, S. Budhani, D. S. Kosson, G. Chen, K. E. Towbin, E. Leibenluft, et al. Abnormal Ventromedial Prefrontal Cortex Function in Children With Psychopathic Traits During Reversal Learning Arch Gen Psychiatry, May 1, 2008; 65(5): 586 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Z. Wheeler and L. K. Fellows The human ventromedial frontal lobe is critical for learning from negative feedback Brain, May 1, 2008; 131(5): 1323 - 1331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Weiler, C. Bellebaum, and I. Daum Aging affects acquisition and reversal of reward-based associative learning Learn. Mem., April 1, 2008; 15(4): 190 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. T. Rolls, C. McCabe, and J. Redoute Expected Value, Reward Outcome, and Temporal Difference Error Representations in a Probabilistic Decision Task Cereb Cortex, March 1, 2008; 18(3): 652 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bellebaum, B. Koch, M. Schwarz, and I. Daum Focal basal ganglia lesions are associated with impairments in reward-based reversal learning Brain, March 1, 2008; 131(3): 829 - 841. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Hallam, N. D. Silverberg, A. K. LaMarre, I. R. A. Mackenzie, and H. H. Feldman Clinical Presentation of Prodromal Frontotemporal Dementia American Journal of Alzheimer's Disease and Other Dementias, January 1, 2008; 22(6): 456 - 467. [Abstract] [PDF]
|
|
|
|
|
|
B.-M. Gu, J.-Y. Park, D.-H. Kang, S. J. Lee, S. Y. Yoo, H. J. Jo, C.-H. Choi, J.-M. Lee, and J. S. Kwon Neural correlates of cognitive inflexibility during task-switching in obsessive-compulsive disorder Brain, January 1, 2008; 131(1): 155 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. K. Fellows and M. J. Farah The Role of Ventromedial Prefrontal Cortex in Decision Making: Judgment under Uncertainty or Judgment Per Se? Cereb Cortex, November 1, 2007; 17(11): 2669 - 2674. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Baxter, D. Gaffan, D. A. Kyriazis, and A. S. Mitchell Orbital Prefrontal Cortex Is Required for Object-in-Place Scene Memory But Not Performance of a Strategy Implementation Task J. Neurosci., October 17, 2007; 27(42): 11327 - 11333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J Frank, A. Scheres, and S. J Sherman Understanding decision-making deficits in neurological conditions: insights from models of natural action selection Phil Trans R Soc B, September 29, 2007; 362(1485): 1641 - 1654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Robbins and A. Roberts Differential Regulation of Fronto-Executive Function by the Monoamines and Acetylcholine Cereb Cortex, September 1, 2007; 17(suppl_1): i151 - i160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Izquierdo, T. K. Newman, J. D. Higley, and E. A. Murray Genetic modulation of cognitive flexibility and socioemotional behavior in rhesus monkeys PNAS, August 28, 2007; 104(35): 14128 - 14133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Murray, J. P. O'Doherty, and G. Schoenbaum What We Know and Do Not Know about the Functions of the Orbitofrontal Cortex after 20 Years of Cross-Species Studies J. Neurosci., August 1, 2007; 27(31): 8166 - 8169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ciaramelli, M. Muccioli, E. Ladavas, and G. di Pellegrino Selective deficit in personal moral judgment following damage to ventromedial prefrontal cortex Soc Cogn Affect Neurosci, June 1, 2007; 2(2): 84 - 92. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. S. Hoffer, S. L. Allen, and M. Mathews Treatment of Psychiatric Symptoms Associated With a Frontal Lobe Tumor Through Surgical Resection Am J Psychiatry, June 1, 2007; 164(6): 877 - 882. [Full Text] [PDF]
|
|
|
|
|
|
T.W Robbins Shifting and stopping: fronto-striatal substrates, neurochemical modulation and clinical implications Phil Trans R Soc B, May 29, 2007; 362(1481): 917 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y Chudasama, J. Kralik, and E. Murray Rhesus Monkeys with Orbital Prefrontal Cortex Lesions Can Learn to Inhibit Prepotent Responses in the Reversed Reward Contingency Task Cereb Cortex, May 1, 2007; 17(5): 1154 - 1159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. V. Valentin, A. Dickinson, and J. P. O'Doherty Determining the Neural Substrates of Goal-Directed Learning in the Human Brain J. Neurosci., April 11, 2007; 27(15): 4019 - 4026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. K. Fellows Advances in understanding ventromedial prefrontal function: The accountant joins the executive Neurology, March 27, 2007; 68(13): 991 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. L. Remijnse, M. M. A. Nielen, A. J. L. M. van Balkom, D. C. Cath, P. van Oppen, H. B. M. Uylings, and D. J. Veltman Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder. Arch Gen Psychiatry, November 1, 2006; 63(11): 1225 - 1236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. H. Rudebeck, M. J. Buckley, M. E. Walton, and M. F. S. Rushworth A role for the macaque anterior cingulate gyrus in social valuation. Science, September 1, 2006; 313(5791): 1310 - 1312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Garon, C. Moore, and D. A. Waschbusch Decision Making in Children With ADHD Only, ADHD-Anxious/Depressed, and Control Children Using a Child Version of the Iowa Gambling Task. J Atten Disord, May 1, 2006; 9(4): 607 - 619. [Abstract] [PDF]
|
|
|
|
|
|
L. K. Fellows Deciding how to decide: ventromedial frontal lobe damage affects information acquisition in multi-attribute decision making Brain, April 1, 2006; 129(4): 944 - 952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Schoenbaum, B. Setlow, M. P. Saddoris, and M. Gallagher Encoding Changes in Orbitofrontal Cortex in Reversal-Impaired Aged Rats J Neurophysiol, March 1, 2006; 95(3): 1509 - 1517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Chamberlain, U. Muller, A. D. Blackwell, L. Clark, T. W. Robbins, and B. J. Sahakian Neurochemical Modulation of Response Inhibition and Probabilistic Learning in Humans Science, February 10, 2006; 311(5762): 861 - 863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Rajah and M. D'Esposito Region-specific changes in prefrontal function with age: a review of PET and fMRI studies on working and episodic memory Brain, September 1, 2005; 128(9): 1964 - 1983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. F. Clarke, S. C. Walker, H. S. Crofts, J. W. Dalley, T. W. Robbins, and A. C. Roberts Prefrontal Serotonin Depletion Affects Reversal Learning But Not Attentional Set Shifting J. Neurosci., January 12, 2005; 25(2): 532 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. K. Fellows and M. J. Farah Different Underlying Impairments in Decision-making Following Ventromedial and Dorsolateral Frontal Lobe Damage in Humans Cereb Cortex, January 1, 2005; 15(1): 58 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. V. Maia and J. L. McClelland From the Cover: A reexamination of the evidence for the somatic marker hypothesis: What participants really know in the Iowa gambling task PNAS, November 9, 2004; 101(45): 16075 - 16080. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. K. Fellows The Cognitive Neuroscience of Human Decision Making: A Review and Conceptual Framework Behav Cogn Neurosci Rev, September 1, 2004; 3(3): 159 - 172. [Abstract] [PDF]
|
|
|
|
|
|
A. Izquierdo, R. K. Suda, and E. A. Murray Bilateral Orbital Prefrontal Cortex Lesions in Rhesus Monkeys Disrupt Choices Guided by Both Reward Value and Reward Contingency J. Neurosci., August 25, 2004; 24(34): 7540 - 7548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. F. Clarke, J. W. Dalley, H. S. Crofts, T. W. Robbins, and A. C. Roberts Cognitive Inflexibility After Prefrontal Serotonin Depletion Science, May 7, 2004; 304(5672): 878 - 880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Izquierdo and E. A. Murray Combined Unilateral Lesions of the Amygdala and Orbital Prefrontal Cortex Impair Affective Processing in Rhesus Monkeys J Neurophysiol, May 1, 2004; 91(5): 2023 - 2039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Berlin, E. T. Rolls, and U. Kischka Impulsivity, time perception, emotion and reinforcement sensitivity in patients with orbitofrontal cortex lesions Brain, May 1, 2004; 127(5): 1108 - 1126. [Abstract] [Full Text] [PDF]
|
|