Brain Advance Access originally published online on July 28, 2004
Brain 2004 127(10):2214-2220; doi:10.1093/brain/awh250
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Brain Vol. 127 No. 10 © Guarantors of Brain 2004; all rights reserved
Astrocytic degeneration relates to the severity of disease in frontotemporal dementia
1 Centre for Education and Research on Ageing, The University of Sydney, Concord, Hospital, Concord and 2 Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, Australia
Correspondence to: Professor Glenda Halliday, Prince of Wales Medical Research Institute, Barker Street, Randwick 2031, Australia E-mail: G.Halliday{at}unsw.edu.au
The main unifying feature of cases with frontotemporal dementia (FTD) is the pattern of brain atrophy. Surprisingly, there are a variety of underlying histopathologies in cases with the clinical features and typical pattern of atrophy characterizing FTD. This suggests that the degenerative mechanism(s) associated with pyramidal cell loss and gliosis in FTD is likely to be similar in the different histopathological forms of the disease. In this study we tested this hypothesis by analysing a common cell death mechanism, apoptosis, in cases of FTD with either Pick's disease (PiD) (n = 9) or frontotemporal lobar degeneration (FTLD) (n = 7) compared with normal controls (n = 10). Tissue sections from previously analysed cases were stained using anti-activated caspase-3 immunohistochemistry, TUNEL, propidium iodide, and cell- and pathology-specific labels. These markers of apoptosis identified both astrocytes and neurons in regions vulnerable to degeneration in all cases of FTD. However, neuronal apoptosis was rare (<2% of neurons), even at early disease stages where there is considerably less frontotemporal atrophy or pyramidal cell loss. This suggests that other cell death mechanisms account for the progressive neuronal loss in FTD. In contrast, astrocytes with beaded processes and other apoptotic features were very frequent in both PiD and FTLD, with the severity of astrocytosis and astrocytic apoptosis correlating with both the degree of neuronal loss and the stage of disease. These findings provide evidence that astrocytic apoptosis occurs as an early event in different histopathological forms of FTD. Furthermore, this astrocytic apoptosis directly relates to the degree of degeneration in FTD, and becomes the overwhelming pathological feature as the disease progresses.
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