Brain, Vol. 127, No. 3, 457-459, 2004
© 2004 Guarantors of Brain
doi: 10.1093/brain/awh113
Functional neuroimaging of schizophrenia: from a genetic predisposition to the emergence of symptoms
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Schizophrenia is common, chronic and disabling. While psychotic features, i.e. delusions, hallucinations and disordered thinking, are critical to diagnosis, accompanying cognitive deficits are receiving increasing attention. Such deficits, occurring early in the course of the disease, are incapacitating, perhaps more so than the psychotic features (Harvey et al., 2003
), and have prognostic significance (Fujii and Wylie, 2003). They may be seen in apparently unaffected relatives of people with schizophrenia (Faraone et al., 1995). In this issue of Brain, Whalley et al. (2004) demonstrate changes in brain responses to cognitive demands in a group of people who are at risk of developing schizophrenia (having two or more first- or second-degree relatives with the disease). Furthermore, a distinctive pattern of brain activation characterizes those
1 Wellcome Trust Senior Research Fellow in Clinical Science, University of Cambridge, UK
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