Brain Advance Access originally published online on February 11, 2004
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Brain, Vol. 127, No. 4, 735-746, 2004
© 2004 Guarantors of Brain
doi: 10.1093/brain/awh106
Event-related beta desynchronization in human subthalamic nucleus correlates with motor performance
1 Sobell Department of Motor Neuroscience and Movement Disorders and 2 Unit of Functional Neurosurgery, Institute of Neurology, London, UK and 3 Department of Neurology and 4 Department of Neurosurgery, Charité Campus Virchow, Humboldt University, Berlin, Germany
Correspondence to: Dr P. Brown, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK E-mail: p.brown{at}ion.ucl.ac.uk
Although the basal ganglia play an important role in self-generated movement, their involvement in externally paced voluntary movement is less clear. We recorded local field potentials (LFPs) from the region of the subthalamic nuclei of eight patients with Parkinson’s disease during the performance of a warned reaction time task in which an imperative cue instructed the subject to move or not to move. In ‘go’ trials, LFP activity in the beta frequency band (
20 Hz) decreased prior to movement, with an onset latency that strongly correlated with mean reaction time across patients. This was followed by a late post-movement increase in beta power. In contrast, in ‘nogo’ trials the beta power drop following imperative signals was prematurely terminated compared with go trials and reversed into an early beta power increase. These differences were manifest as power increases when go trials were subtracted from nogo trials. In six patients these relative beta power increases in nogo–go difference trials were of shorter latency than the respective reaction time. The findings suggest that, firstly, the subthalamic nucleus is involved in the preparation of externally paced voluntary movements in humans and, secondly, the degree of synchronization of subthalamic nucleus activity in the beta band may be an important determinant of whether motor programming and movement initiation is favoured or suppressed.
Key Words: subthalamic nucleus; Parkinson’s disease; synchronous oscillatory activity; beta power modulations; motor programming
Abbreviations: DBS = deep-brain stimulation; ERD = event-related desynchronization; ERS = event-related synchronization; ERP = event-related potential; LFP = local field potential; STN = subthalamic nucleus
Received October 29, 2003. Revised December 3, 2003. Accepted December 9, 2003.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  N. Swann, N. Tandon, R. Canolty, T. M. Ellmore, L. K. McEvoy, S. Dreyer, M. DiSano, and A. R. Aron Intracranial EEG Reveals a Time- and Frequency-Specific Role for the Right Inferior Frontal Gyrus and Primary Motor Cortex in Stopping Initiated Responses J. Neurosci., October 7, 2009; 29(40): 12675 - 12685. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Cruz, N. Mallet, P. J. Magill, P. Brown, and B. B. Averbeck Effects of Dopamine Depletion on Network Entropy in the External Globus Pallidus J Neurophysiol, August 1, 2009; 102(2): 1092 - 1102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Degos, J.-M. Deniau, M. Chavez, and N. Maurice Chronic but not Acute Dopaminergic Transmission Interruption Promotes a Progressive Increase in Cortical Beta Frequency Synchronization: Relationships to Vigilance State and Akinesia Cereb Cortex, July 1, 2009; 19(7): 1616 - 1630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.C.M. van Wijk, A. Daffertshofer, N. Roach, and P. Praamstra A Role of Beta Oscillatory Synchrony in Biasing Response Competition? Cereb Cortex, June 1, 2009; 19(6): 1294 - 1302. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Fuentes, P. Petersson, W. B. Siesser, M. G. Caron, and M. A. L. Nicolelis Spinal Cord Stimulation Restores Locomotion in Animal Models of Parkinson's Disease Science, March 20, 2009; 323(5921): 1578 - 1582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Weinberger, W. D. Hutchison, A. M. Lozano, M. Hodaie, and J. O. Dostrovsky Increased Gamma Oscillatory Activity in the Subthalamic Nucleus During Tremor in Parkinson's Disease Patients J Neurophysiol, February 1, 2009; 101(2): 789 - 802. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Moran, H. Bergman, Z. Israel, and I. Bar-Gad Subthalamic nucleus functional organization revealed by parkinsonian neuronal oscillations and synchrony Brain, December 1, 2008; 131(12): 3395 - 3409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Xue, A. R. Aron, and R. A. Poldrack Common Neural Substrates for Inhibition of Spoken and Manual Responses Cereb Cortex, August 1, 2008; 18(8): 1923 - 1932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Kuhn, F. Kempf, C. Brucke, L. Gaynor Doyle, I. Martinez-Torres, A. Pogosyan, T. Trottenberg, A. Kupsch, G.-H. Schneider, M. I. Hariz, et al. High-Frequency Stimulation of the Subthalamic Nucleus Suppresses Oscillatory {beta} Activity in Patients with Parkinson's Disease in Parallel with Improvement in Motor Performance J. Neurosci., June 11, 2008; 28(24): 6165 - 6173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Mallet, A. Pogosyan, A. Sharott, J. Csicsvari, J. P. Bolam, P. Brown, and P. J. Magill Disrupted Dopamine Transmission and the Emergence of Exaggerated Beta Oscillations in Subthalamic Nucleus and Cerebral Cortex J. Neurosci., April 30, 2008; 28(18): 4795 - 4806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lalo, S. Thobois, A. Sharott, G. Polo, P. Mertens, A. Pogosyan, and P. Brown Patterns of Bidirectional Communication between Cortex and Basal Ganglia during Movement in Patients with Parkinson Disease J. Neurosci., March 19, 2008; 28(12): 3008 - 3016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Chambers, M. A. Bellgrove, I. C. Gould, T. English, H. Garavan, E. McNaught, M. Kamke, and J. B. Mattingley Dissociable Mechanisms of Cognitive Control in Prefrontal and Premotor Cortex J Neurophysiol, December 1, 2007; 98(6): 3638 - 3647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Praamstra and P. Pope Slow Brain Potential and Oscillatory EEG Manifestations of Impaired Temporal Preparation in Parkinson's Disease J Neurophysiol, November 1, 2007; 98(5): 2848 - 2857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Tripp and C. Eliasmith Neural Populations Can Induce Reliable Postsynaptic Currents without Observable Spike Rate Changes or Precise Spike Timing Cereb Cortex, August 1, 2007; 17(8): 1830 - 1840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Purzner, G. O. Paradiso, D. Cunic, J. A. Saint-Cyr, T. Hoque, A. M. Lozano, A. E. Lang, E. Moro, M. Hodaie, F. Mazzella, et al. Involvement of the Basal Ganglia and Cerebellar Motor Pathways in the Preparation of Self-Initiated and Externally Triggered Movements in Humans J. Neurosci., May 30, 2007; 27(22): 6029 - 6036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Aron, T. E. Behrens, S. Smith, M. J. Frank, and R. A. Poldrack Triangulating a Cognitive Control Network Using Diffusion-Weighted Magnetic Resonance Imaging (MRI) and Functional MRI J. Neurosci., April 4, 2007; 27(14): 3743 - 3752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Androulidakis, A. A. Kuhn, C. Chu Chen, P. Blomstedt, F. Kempf, A. Kupsch, G.-H. Schneider, L. Doyle, P. Dowsey-Limousin, M. I. Hariz, et al. Dopaminergic therapy promotes lateralized motor activity in the subthalamic area in Parkinson's disease Brain, February 1, 2007; 130(2): 457 - 468. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Green, S. Wang, S. Purvis, S. L. F. Owen, P. G. Bain, J. F. Stein, A. Guz, T. Z. Aziz, and D. J. Paterson Identifying cardiorespiratory neurocircuitry involved in central command during exercise in humans J. Physiol., January 15, 2007; 578(2): 605 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Weinberger, N. Mahant, W. D. Hutchison, A. M. Lozano, E. Moro, M. Hodaie, A. E. Lang, and J. O. Dostrovsky Beta Oscillatory Activity in the Subthalamic Nucleus and Its Relation to Dopaminergic Response in Parkinson's Disease J Neurophysiol, December 1, 2006; 96(6): 3248 - 3256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Magill, A. Sharott, J. P. Bolam, and P. Brown Delayed synchronization of activity in cortex and subthalamic nucleus following cortical stimulation in the rat J. Physiol., August 1, 2006; 574(3): 929 - 946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Alonso-Frech, I. Zamarbide, M. Alegre, M. C. Rodriguez-Oroz, J. Guridi, M. Manrique, M. Valencia, J. Artieda, and J. A. Obeso Slow oscillatory activity and levodopa-induced dyskinesias in Parkinson's disease Brain, July 1, 2006; 129(7): 1748 - 1757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Plaha, Y. Ben-Shlomo, N. K. Patel, and S. S. Gill Stimulation of the caudal zona incerta is superior to stimulation of the subthalamic nucleus in improving contralateral parkinsonism Brain, July 1, 2006; 129(7): 1732 - 1747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Coxon, C. M. Stinear, and W. D. Byblow Intracortical Inhibition During Volitional Inhibition of Prepared Action J Neurophysiol, June 1, 2006; 95(6): 3371 - 3383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Klostermann, M. Wahl, F. Marzinzik, G.-H. Schneider, A. Kupsch, and G. Curio Mental chronometry of target detection: human thalamus leads cortex Brain, April 1, 2006; 129(4): 923 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Marceglia, G. Foffani, A. M. Bianchi, G. Baselli, F. Tamma, M. Egidi, and A. Priori Dopamine-dependent non-linear correlation between subthalamic rhythms in Parkinson's disease J. Physiol., March 15, 2006; 571(3): 579 - 591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Kuhn, L. Doyle, A. Pogosyan, K. Yarrow, A. Kupsch, G.-H. Schneider, M. I. Hariz, T. Trottenberg, and P. Brown Modulation of beta oscillations in the subthalamic area during motor imagery in Parkinson's disease Brain, March 1, 2006; 129(3): 695 - 706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Fogelson, D. Williams, M. Tijssen, G. van Bruggen, H. Speelman, and P. Brown Different Functional Loops between Cerebral Cortex and the Subthalmic Area in Parkinson's Disease Cereb Cortex, January 1, 2006; 16(1): 64 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G Foffani, A. M Bianchi, G Baselli, and A Priori Movement-related frequency modulation of beta oscillatory activity in the human subthalamic nucleus J. Physiol., October 15, 2005; 568(2): 699 - 711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Meissner, A. Leblois, D. Hansel, B. Bioulac, C. E. Gross, A. Benazzouz, and T. Boraud Subthalamic high frequency stimulation resets subthalamic firing and reduces abnormal oscillations Brain, October 1, 2005; 128(10): 2372 - 2382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Kuhn, M. I. Hariz, P. Silberstein, S. Tisch, A. Kupsch, G. -H. Schneider, P. Limousin-Dowsey, K. Yarrow, and P. Brown Activation of the subthalamic region during emotional processing in Parkinson disease Neurology, September 13, 2005; 65(5): 707 - 713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Gilbertson, E. Lalo, L. Doyle, V. Di Lazzaro, B. Cioni, and P. Brown Existing Motor State Is Favored at the Expense of New Movement during 13-35 Hz Oscillatory Synchrony in the Human Corticospinal System J. Neurosci., August 24, 2005; 25(34): 7771 - 7779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sharott, P. J Magill, J. P. Bolam, and P. Brown Directional analysis of coherent oscillatory field potentials in the cerebral cortex and basal ganglia of the rat J. Physiol., February 1, 2005; 562(3): 951 - 963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Paradiso, D. Cunic, J. A. Saint-Cyr, T. Hoque, A. M. Lozano, A. E. Lang, and R. Chen Involvement of human thalamus in the preparation of self-paced movement Brain, December 1, 2004; 127(12): 2717 - 2731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. D. Hutchison, J. O. Dostrovsky, J. R. Walters, R. Courtemanche, T. Boraud, J. Goldberg, and P. Brown Neuronal Oscillations in the Basal Ganglia and Movement Disorders: Evidence from Whole Animal and Human Recordings J. Neurosci., October 20, 2004; 24(42): 9240 - 9243. [Full Text] [PDF]
|
|
|
|
|
|
P. J. Magill, A. Sharott, J. P. Bolam, and P. Brown Brain State-Dependency of Coherent Oscillatory Activity in the Cerebral Cortex and Basal Ganglia of the Rat J Neurophysiol, October 1, 2004; 92(4): 2122 - 2136. [Abstract] [Full Text] [PDF]
|
|