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Brain 2005 128(8):1743-1744; doi:10.1093/brain/awh594
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© The Author (2005). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

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‘Pain in the head in connection with cerebral disease’. By David Ferrier, MD, FRS Brain 1879; 1: 467–83.

‘It seems at first strange, not to say unaccountable, that the centres of sensation and perception are themselves devoid of sensibility or sensitivity, and may be cut, lacerated, burnt, or otherwise injured, without the slightest indication of local suffering being manifested.’ But, as Ferrier goes on to explain, those organs that do give rise to pain when injured, have peripheral end-organs and nerve terminations that are capable of stimulation; and they are connected by nerve trunks to neural centres. Sensation depends on these three elements being in continuity. Thus, there are no sensory ‘nerves’, merely sensory . . . [Full Text of this Article]

Alastair Compston

Cambridge, UK


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