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Brain 2006 129(1):6-7; doi:10.1093/brain/awh717
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© The Author (2006). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Scientific Commentary

New advances in the pathophysiology of focal dystonias

The first 10% of the full text of this article appears below.

In this issue of Brain two studies using different techniques report novel findings on the pathophysiology of focal dystonias. The first paper (Dresel et al., 2006Go) reports a functional MRI (fMRI) study in patients with cranial dystonia during a whistling task and the second (Fiorio et al., 2006Go) describes the results of a study on mental body rotation in patients with writer's cramp. Both papers open interesting new questions for further study.

Dystonia is a syndrome characterized by excessive and sustained muscle contractions causing abnormal postures and involuntary movements. It is attributed to basal ganglia abnormalities and to a dysfunction of the cortico-striato-thalamo-cortical circuits. Focal dystonia is more common than generalized dystonia. It affects a . . . [Full Text of this Article]

Alfredo Berardelli

Department of Neurological Sciences and Neuromed Institute, University of Rome ‘La Sapienza’, Rome, Italy E-mail: alfredo.berardelli@uniroma1.it


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