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Brain 2006 129(11):2811-2822; doi:10.1093/brain/awl275
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© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Review Articles

Alzheimer's centennial legacy: origins, landmarks and the current status of knowledge concerning cognitive aspects

John R. Hodges1,2

1 MRC Cognition and Brain Sciences Unit Cambridge, UK 2 Department of Clinical Neurosciences, Addenbrooke's Hospital Cambridge, UK

Correspondence to: Prof. John R. Hodges, MRC-CBU, 15 Chaucer Road, Cambridge CB2 2EF, UK E-mail: john.hodges{at}mrc-cbu.cam.ac.uk

This review commemorates 100 years of research into Alzheimer's disease and, by happy coincidence, the publication of 100 papers in Brain on the topic. The first part of the review traces the evolution of concepts and landmarks in the modern history of Alzheimer's disease. It highlights the continuing role of careful clinico-pathological studies which have set the stage for each major leap forwards, such as the emergence of the cholinergic hypothesis, and the realistation that subjects pass through an amnestic prodrome which is thought to reflect dysfunction of the hippocampal formation before the onset of full blown dementia. The contribution of structural and functional imaging is briefly described. The important contribution of publications in Brain is illustrated throughout the first section. The second part attempts to review the current status of our knowledge concerning behavioural, neuropsychological and neuropsychiatric aspects of the disease, emphasizing areas of continuing controversy.

Key Words: Alzheimer's disease; dementia; memory; semantic memory

Abbreviations: MCI, mild cognitive impairment

Received July 18, 2006. Revised August 31, 2006. Accepted August 31, 2006.


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