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Scientific Commentary |
Axonal protection in multiple sclerosis—a particular need during remyelination?
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The current issue of Brain contains four papers that illuminate different aspects of inflammatory demyelinating disease, especially multiple sclerosis (Black et al., 2006
; Coman et al., 2006; Howell et al., 2006; Patrikios et al., 2006). One paper focuses on axonal protection, while the others describe aspects of spontaneous remyelination in the disease. Promoting remyelination is a major therapeutic goal in multiple sclerosis, but some observations from the current papers raise the possibility that remyelination may transiently render axons vulnerable to degeneration before long-term protection is achieved, as discussed below.
In recent years the identification of strategies to protect axons from degeneration in multiple sclerosis has emerged as a major research priority. This emphasis is in response to the realisation that axonal degeneration is substantial in the disease (Trapp et al., 1998; Ganter et al., 1999), and that it
Department of Clinical Neurosciences, Institute of Psychiatry, King's College London 19 Newcomen Street, London, SE1 1UL, UK
E-mail: kenneth.smith@kcl.ac.uk
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