Skip Navigation


Brain Advance Access originally published online on December 19, 2005
Brain 2006 129(2):517-526; doi:10.1093/brain/awh707
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Data
Right arrow All Versions of this Article:
129/2/517    most recent
awh707v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Brain
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (26)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Boven, L. A.
Right arrow Articles by Laman, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Boven, L. A.
Right arrow Articles by Laman, J. D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author (2005). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis

Leonie A. Boven1, Marjan Van Meurs1, Marloes Van Zwam1, Annet Wierenga-Wolf1, Rogier Q. Hintzen2, Rolf G. Boot4, Johannes M. Aerts4, Sandra Amor5, Edward E. Nieuwenhuis3,* and Jon D. Laman1,*

1 Departments of Immunology and 2 Neurology, part of the multiple sclerosis Centre ErasMS, 3 Department of Pediatrics, Erasmus Medical Center, Rotterdam, 4 Department of Medical Biochemistry, Academic Medical Center Amsterdam, 5 Biomedical Primate Research Center, part of the multiple sclerosis Centre ErasMS, Rijswijk, The Netherlands

Correspondence to: Leonie A. Boven, PhD, Department of Immunology, Ee802, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands E-mail: l.boven{at}erasmusmc.nl

Multiple sclerosis lesion activity concurs with the extent of inflammation, demyelination and axonal suffering. Pro-inflammatory myeloid cells contribute to lesion development, but the self-limiting nature of lesions implies as yet unidentified anti-inflammatory mechanisms. We addressed the hypothesis that myelin ingestion by myeloid cells induces a foamy appearance and confers anti-inflammatory function. First, we show that myelin-containing foam cells in multiple sclerosis lesions consistently express a series of anti-inflammatory molecules while lacking pro-inflammatory cytokines. Second, unique location-dependent cytokine and membrane receptor expression profiles imply functional specialization allowing for differential responses to micro-environmental cues. A novel human in vitro model of foamy macrophages functionally confirmed that myelin ingestion induces an anti-inflammatory programme. Foamy macrophages are unable to respond to prototypical inflammatory stimuli but do express molecules involved in suppression of inflammation. These findings provide novel insights into the mechanisms of lesion control and may open new roads to intervention.

Key Words: autoimmunity; brain; chemokines; cytokines; inflammation

Abbreviations: MOG = myelin oligodendrocyte glycoprotein; NAWM = normal appearing white matter; ORO = oil red O; PGES = prostaglandin E2 synthase

.

Received August 1, 2005. Revised October 11, 2005. Accepted October 27, 2005.

* These authors contributed equally to this work.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?

Related articles in Brain:

Editorial
Alastair Compston
Brain 2006 129: 283-284. [Extract] [FREE Full Text]  



This article has been cited by other articles:


Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. G. Ionita, A. Vink, I. E. Dijke, J. D. Laman, W. Peeters, P. H. van der Kraak, F. L. Moll, J.-P. P.M. de Vries, G. Pasterkamp, and D. P.V. de Kleijn
High Levels of Myeloid-Related Protein 14 in Human Atherosclerotic Plaques Correlate With the Characteristics of Rupture-Prone Lesions
Arterioscler Thromb Vasc Biol, August 1, 2009; 29(8): 1220 - 1227.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Lambert, J. Desbarats, N. Arbour, J. A. Hall, A. Olivier, A. Bar-Or, and J. P. Antel
Dendritic Cell Differentiation Signals Induce Anti-Inflammatory Properties in Human Adult Microglia
J. Immunol., December 15, 2008; 181(12): 8288 - 8297.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
L. Piccio, C. Buonsanti, M. Cella, I. Tassi, R. E. Schmidt, C. Fenoglio, J. Rinker II, R. T. Naismith, P. Panina-Bordignon, N. Passini, et al.
Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation
Brain, November 1, 2008; 131(11): 3081 - 3091.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
R. Lopez-Vales, X. Navarro, T. Shimizu, C. Baskakis, G. Kokotos, V. Constantinou-Kokotou, D. Stephens, E. A. Dennis, and S. David
Intracellular phospholipase A2 group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury
Brain, October 1, 2008; 131(10): 2620 - 2631.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
C Trebst, F Konig, R. Ransohoff, W Bruck, and M Stangel
CCR5 expression on macrophages/microglia is associated with early remyelination in multiple sclerosis lesions
Multiple Sclerosis, July 1, 2008; 14(6): 728 - 733.
[Abstract] [PDF]

Home page
 Am. J. Pathol.Home page
T. Skripuletz, M. Lindner, A. Kotsiari, N. Garde, J. Fokuhl, F. Linsmeier, C. Trebst, and M. Stangel
Cortical Demyelination Is Prominent in the Murine Cuprizone Model and Is Strain-Dependent
Am. J. Pathol., April 1, 2008; 172(4): 1053 - 1061.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
K. Hamamcioglu and A. Reder
Interferon-{beta} regulates cytokines and BDNF: greater effect in relapsing than in progressive multiple sclerosis
Multiple Sclerosis, May 1, 2007; 13(4): 459 - 470.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
Y. Liu, W. Hao, M. Letiembre, S. Walter, M. Kulanga, H. Neumann, and K. Fassbender
Suppression of Microglial Inflammatory Activity by Myelin Phagocytosis: Role of p47-PHOX-Mediated Generation of Reactive Oxygen Species
J. Neurosci., December 13, 2006; 26(50): 12904 - 12913.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.