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Brain 2006 129(4):827-829; doi:10.1093/brain/awl059
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© The Author (2006). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

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The frontal lobe in man: a clinical study of maximum removals. From the Department of Neurology and Neurosurgery, McGill University, and the Montreal Neurological Institute. By Wilder Penfield and Joseph Evans. Brain 1935; 58: 115–133.

The authors introduce their study of three individuals in whom a substantial part of one frontal lobe is removed with a cautionary note: the opportunity provided by investigating the effects of neurosurgery may be confounded by ‘bilateral representation of many cerebral processes which take place in this terra incognita’, and by the disadvantage of including examples of cerebral tumour since these may have distant effects through displacement and infiltration. Thus, although cases with epilepsy are best, those with a very wide tumour resection—extending well into normal brain—may yet be informative. That said, ‘it may be urged that to destroy a delicate instrument is not the best way of studying its function’.

Case 1, described . . . [Full Text of this Article]

Alastair Compston

Cambridge


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