© The Author (2007). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
The Lewy body, the hallucination, the atrophy and the physiology
Senior Research Associate, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK
E-mail: peter.nestor@mrc-cbu.cam.ac.uk
Received April 4, 2007. Accepted May 15, 2007.
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Sir, Recent publication of Whitwell et al. (2007
) in Brain offers a useful addition to our understanding of dementia with Lewy bodies (DLB). In a very large n study, they offer the most definitive evidence yet published of what previous studies have been hinting at in recent years; this being that cortical atrophy, particularly when compared to Alzheimer's disease (AD), is not a major feature of DLB. In contradistinction to a well-matched sample of AD patients, they found minimal cortical involvement in DLB and argued, very plausibly, that