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Brain Advance Access originally published online on July 12, 2007
Brain 2007 130(11):e83; doi:10.1093/brain/awm153
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© The Author (2007). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

A few remarks on assessing magnocellular sensitivity in Schizophrenic patients

Bernt Christian Skottun1 and John Skoyles2,3

1Skottun Research, Oakland, California, USA, 2Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, London and 3Centre for Philosophy of Natural and Social Science, London School of Economics, London, UK

Correspondence to: John R. Skoyles, PhD, Centre for Philosophy of Natural and Social Science, Lakatos Building, London School of Economics, Houghton Street, London, WC2A 2AE, UK E-mail: j.skoyles@ucl.ac.uk

Received February 23, 2007. Revised April 24, 2007. Accepted June 8, 2007.

The first 150 words of the full text of this article appear below.

Sir, Butler and colleagues (2007Go) recorded event-related potentials in an attempt to isolate magnocellular activity in individuals with schizophrenia, and concluded that, these individuals ‘show significant and substantial deficits in early visual processing affecting the subcortical magnocellular pathway’ (Butler et al., 2007Go, p. 428). In their experiments, Butler et al. (2007Go) relied upon two stimulus manipulations to isolate magnocellular responses: (i) spatial frequency, and (ii) contrast. With regard to these two stimulus dimensions Butler et al. (2007Go, p. 418) wrote: ‘[r]ecent visual evoked potential work in humans with magnocellular and parvocellular preferential stimuli demonstrates that the spatial characteristics and contrast dependence of these pathways are similar to those found in monkeys ...’. We wish to comment upon these manipulations in light of this statement.

The first stimulus manipulation used by Butler and colleagues (2007Go), ‘spatial frequency’, can be used to reliably differentiate . . . [Full Text of this Article]


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