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Brain Advance Access originally published online on August 29, 2007
Brain 2007 130(12):3149-3154; doi:10.1093/brain/awm186
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© The Author (2007). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Distinct regional atrophy in the corpus callosum of patients with temporal lobe epilepsy

Bernd Weber1,2, Eileen Luders3, Jennifer Faber1,2, Sabine Richter4, Carlos M. Quesada1,2, Horst Urbach5, Paul M. Thompson3, Arthur W. Toga3, Christian E. Elger1,2 and Christoph Helmstaedter1

1Department of Epileptology, University of Bonn, 2Department of NeuroCognition, Life & Brain Center, Bonn, Germany, 3Laboratory of Neuroimaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA, 4Department of Neurosurgery, University of Bonn and 5Department of Radiology, University of Bonn, Germany

Correspondence to: Bernd Weber, MD, Department of NeuroCognition, Life & Brain Center, Sigmund Freud Str. 25,53127 Bonn, Germany E-mail: bernd.weber{at}ukb.uni-bonn.de

We analysed the influence of mesial temporal lobe epilepsy on the thickness of the corpus callosum (CC) in a large sample of well-characterized patients (n = 96) and healthy controls (n = 28). In particular, we investigated whether callosal structures are differentially affected depending on the affected hemisphere and age of epilepsy onset. Overall, we observed that epilepsy is associated with a decreased thickness in posterior callosal regions. Patients with an early onset, especially patients with left onset, additionally exhibited a smaller callosal thickness in more anterior and midbody regions. These findings may reflect non-specific as well as specific effects of temporal lobe epilepsy on CC development and interhemispheric connectivity.

Key Words: corpus callosum; temporal lobe epilepsy; MRI

Abbreviations: CC, corpus callosum; TLE, temporal lobe epilepsy

Received January 26, 2007. Revised July 4, 2007. Accepted July 18, 2007.


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