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Brain Advance Access originally published online on February 9, 2007
Brain 2007 130(3):740-752; doi:10.1093/brain/awl375
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© The Author (2007). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Auditory cortical activity in amnestic mild cognitive impairment: relationship to subtype and conversion to dementia

Edward J. Golob1,2,3, Rie Irimajiri1 and Arnold Starr1,2

1Department of Neurology, 2Institute for Brain Aging and Dementia, University of California, CA, Irvine and 3Department of Psychology and Program in Neuroscience, Tulane University, New Orleans, LA, USA

Corresponding author: Edward J. Golob, PhD, Department of Psychology, 3067 Percival Stern Hall, Tulane University, New Orleans, LA 70118, USA E-mail: egolob{at}tulane.edu

Mild cognitive impairment (MCI) patients have a high risk of converting to Alzheimer's disease. The most common diagnostic subtypes of MCI have an episodic memory disorder (amnestic MCI) occurring either alone [single domain (SD)] or with other cognitive impairments [multiple domain (MD)]. Previous studies report increased amplitudes of auditory cortical potentials in MCI, but their relationships to MCI subtypes and clinical outcomes were not defined. We studied subjects with amnestic MCI (n = 41: 28 SD, 13 MD), Alzheimer's disease (n = 14), and both younger (n = 22) and age-matched older controls (n = 44). Baseline auditory sensory (P50, N100) and cognitive potentials (P300) were recorded during an auditory discrimination task. MCI patients were followed for up to 5 years, and outcomes were classified as (i) continued diagnosis of MCI (MCI-stable, n = 16), (ii) probable Alzheimer's disease (MCI-convert, n = 18), or other outcomes (n = 7). Auditory potentials were analysed as a function of MCI diagnosis and outcomes, and compared with young, older controls, and mild Alzheimer's disease subjects. P50 amplitude increased with normal ageing, and had additional increases in MCI as a function of both initial diagnosis (MD > than SD) and outcome (MCI-convert > MCI-stable). P300 latency increased with normal ageing, and had additional increases in MCI but did not differ among outcomes. We conclude that auditory cortical sensory potentials differ among amnestic MCI subtypes and outcomes occurring up to 5 years later.

Key Words: MCI; single domain; multiple domain; event-related potentials; EEG

Abbreviations: MCI, mild cognitive impairment; SD, single domain

Received August 7, 2006. Revised November 13, 2006. Accepted December 18, 2006.


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