Brain Advance Access originally published online on September 26, 2007
Brain 2008 131(1):e87; doi:10.1093/brain/awm221
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© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Hypocretin (orexin) and melanin concentrating hormone loss and the symptoms of Parkinson's disease
Department of Psychiatry, University of California at Los Angeles, Los Angeles, CA 90095, Neurobiology Research (151A3), Veterans Administration Greater Los Angeles Healthcare System, North Hills, CA 91343 and Brain Research Institute, University of California at Los Angeles, Los Angeles, CA 90095
Correspondence to: Jerome M. Siegel, PhD, UCLA/VAGLAHS – Sepulveda, Neurobiology Research (151A3), 16111 Plummer Street, North Hills, CA 91343, USA E-mail: jsiegel@ucla.edu
Key Words: Parkinson; narcolepsy; sleep; hypocretin; orexin; melanin concentrating hormone
| The first 10% of the full text of this article appears below. |
We reported that Parkinson's disease (PD) patients have a substantial loss of hypocretin (Hcrt) cells (Thannickal et al., 2007
). As two of the authors of the letter to which we are responding have emphasized in their prior publication (Baumann et al., 2005
), and as other groups have reported, the sleep disturbances associated with PD are a major complaint in a large proportion of these patients (Arnulf et al., 2000
; Frucht et al., 2000
; Arnulf et al., 2002
; Frucht, 2002
;
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